Comparison of Serum Malondialdehyde and Paraoxonase-1 Levels in Patients with Epilepsy with and without Status Epilepticus

Ahmet Dündar; Demet Arslan; Gülsüm Çelik Uysal; Ahmet Yılmaz

Comparison of Serum Malondialdehyde and Paraoxonase-1 Levels in Patients with Epilepsy with and without Status Epilepticus

Öz

Aim: The underlying pathophysiological mechanisms in epilepsy are still not fully known. Paraoxonase (PON)-1 activity and malondialdehyde (MDA) levels are biomarkers used in the measurement of oxidative stress. Studies show that oxidative stress has a role in the pathophysiology of epilepsy. The aim of our study is to evaluate serum PON-1 activity and MDA levels in epilepsy patients with and without status epilepticus (SE). Materials and Method: The subjects included in the study were established in two groups. Group I: The patient diagnosed with status epilepticus (n=30), group II: 30 adult patients with epilepsy who were in the outpatient policlinic follow-up and were not in status were included in the study. Serum MDA levels and PON-1 activity were measured by spectrophotometric method in the biochemistry laboratory. Results: Serum MDA levels were found to be 86.8±32.4 nmol/ mL in patients with SE and 65.8±15.7 nmol/mL in patients without SE. Serum PON-1 activity was 180.8±28.3 U/L in patients with SE and 170.2±25.0 U/L in patients without SE. When patients with SE and patients without SE were compared, serum MDA levels were found to be higher than patients without SE and statistically significant (p<0.001). There was no significant difference between the two patient groups in terms of PON-1 activity (p>0.05). Conclusion: The results of our study indicate that the oxidant/ antioxidant balance in the pathogenesis of status epilepticus has deteriorated in favor of oxidative stress and the antioxidant system cannot give an adequate response. Larger research should be conducted to evaluate the use of serum MDA levels as a biomarker.

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Ahmet Dündar Bu kişi benim
Türkiye

Demet Arslan Bu kişi benim
Türkiye

Gülsüm Çelik Uysal Bu kişi benim
Türkiye

Ahmet Yılmaz Bu kişi benim
Türkiye

Yayımlanma Tarihi

26 Nisan 2023

Gönderilme Tarihi

11 Mart 2022

Kabul Tarihi

9 Ocak 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 13 Sayı: 1

IZ

https://izlik.org/JA86CY77PM

Kaynak Göster

RIS / Bibtex

APA

Dündar, A., Arslan, D., Çelik Uysal, G., & Yılmaz, A. (2023). Comparison of Serum Malondialdehyde and Paraoxonase-1 Levels in Patients with Epilepsy with and without Status Epilepticus. Kafkas Journal of Medical Sciences, 13(1), 18-23. https://izlik.org/JA86CY77PM

AMA

1.Dündar A, Arslan D, Çelik Uysal G, Yılmaz A. Comparison of Serum Malondialdehyde and Paraoxonase-1 Levels in Patients with Epilepsy with and without Status Epilepticus. KAFKAS TIP BİL DERG. 2023;13(1):18-23. https://izlik.org/JA86CY77PM

Chicago

Dündar, Ahmet, Demet Arslan, Gülsüm Çelik Uysal, ve Ahmet Yılmaz. 2023. “Comparison of Serum Malondialdehyde and Paraoxonase-1 Levels in Patients with Epilepsy with and without Status Epilepticus”. Kafkas Journal of Medical Sciences 13 (1): 18-23. https://izlik.org/JA86CY77PM.

EndNote

Dündar A, Arslan D, Çelik Uysal G, Yılmaz A (01 Nisan 2023) Comparison of Serum Malondialdehyde and Paraoxonase-1 Levels in Patients with Epilepsy with and without Status Epilepticus. Kafkas Journal of Medical Sciences 13 1 18–23.

IEEE

[1]A. Dündar, D. Arslan, G. Çelik Uysal, ve A. Yılmaz, “Comparison of Serum Malondialdehyde and Paraoxonase-1 Levels in Patients with Epilepsy with and without Status Epilepticus”, KAFKAS TIP BİL DERG, c. 13, sy 1, ss. 18–23, Nis. 2023, [çevrimiçi]. Erişim adresi: https://izlik.org/JA86CY77PM

ISNAD

Dündar, Ahmet - Arslan, Demet - Çelik Uysal, Gülsüm - Yılmaz, Ahmet. “Comparison of Serum Malondialdehyde and Paraoxonase-1 Levels in Patients with Epilepsy with and without Status Epilepticus”. Kafkas Journal of Medical Sciences 13/1 (01 Nisan 2023): 18-23. https://izlik.org/JA86CY77PM.

JAMA

1.Dündar A, Arslan D, Çelik Uysal G, Yılmaz A. Comparison of Serum Malondialdehyde and Paraoxonase-1 Levels in Patients with Epilepsy with and without Status Epilepticus. KAFKAS TIP BİL DERG. 2023;13:18–23.

MLA

Dündar, Ahmet, vd. “Comparison of Serum Malondialdehyde and Paraoxonase-1 Levels in Patients with Epilepsy with and without Status Epilepticus”. Kafkas Journal of Medical Sciences, c. 13, sy 1, Nisan 2023, ss. 18-23, https://izlik.org/JA86CY77PM.

Vancouver

1.Ahmet Dündar, Demet Arslan, Gülsüm Çelik Uysal, Ahmet Yılmaz. Comparison of Serum Malondialdehyde and Paraoxonase-1 Levels in Patients with Epilepsy with and without Status Epilepticus. KAFKAS TIP BİL DERG [Internet]. 01 Nisan 2023;13(1):18-23. Erişim adresi: https://izlik.org/JA86CY77PM