Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature

Suat Şen; Fettah Acıbucu; Asım Tekın; Neşe Bülbül; Ekin Yiğit Köroğlu

Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature

Abstract

Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by hypercalcemia and a high or normal parathyroid hormone (PTH) level inconsistent with calcium. Complications caused by hypercalcemia or excess PTH in patients affect many systems. Therefore, early diagnosis of PHPT can help prevent complications and determine the treatment. Method: In our study, a total of 154 patients, 122 women and 32 men, who were diagnosed with PHPT in the Endocrinology outpatient clinic were retrospectively reviewed and evaluated in the light of the literature. Results: The mean age of the patients was 53.83±13.80 years. Detected mean values for calcium were 11.83±1.28 mg/dl, for phosphorus 2.47±0.57 mg/dl, for PTH 357.32±424.08 pg/ml, for vitamin 25OH D₃ 16.58±9.57 ng/ml, for estimated glomerular filtration rate (eGFR) was 99.03±23.84 ml/min/1.7 and for urinary calcium amount was 381.80±204.11 mg/24h. Bone mineral density (BMD) measurements were made in 64.3% (n: 99) of the patients, 38.4 % (n: 38) had osteopenia, and 42.4 % (n: 42) had osteoporosis. A history of urinary stones was found in 35.7% (n: 55) of the patients, and stone findings were found on ultrasonography in 36.1 % (n: 35). In total, 37% (n: 57) of the cases developed nephrolithiasis as a complication. In the localization study, adenoma was detected in 76.8% (n: 116) of the patients by ultrasonography, while 70.7% (n: 106) were found positive by Tc99 sestamibi scan. The lower right part was the most commonly detected adenoma localization in both imaging. In the pathology results of the operated patients, 91.5% (n: 118) were reported as adenomas. In the follow-up of the operated patients, recurrence was detected in 4.6% (n: 6). Conclusion: Early diagnosis and treatment of PHPT are important to prevent serious complications. The absence of serious complications in the cases in our study shows the importance of early diagnosis.

Keywords

References

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Details

Primary Language

English

Subjects

Clinical Sciences

Journal Section

Research Article

Authors

Suat Şen This is me
Türkiye

Fettah Acıbucu This is me
Türkiye

Asım Tekın This is me
Türkiye

Neşe Bülbül This is me
Türkiye

Ekin Yiğit Köroğlu This is me
Türkiye

Publication Date

April 26, 2023

Submission Date

September 20, 2022

Acceptance Date

February 12, 2023

Published in Issue

Year 2023 Volume: 13 Number: 1

IZ

https://izlik.org/JA67BY65CA

Cite

RIS / Bibtex

APA

Şen, S., Acıbucu, F., Tekın, A., Bülbül, N., & Köroğlu, E. Y. (2023). Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature. Kafkas Journal of Medical Sciences, 13(1), 78-81. https://izlik.org/JA67BY65CA

AMA

1.Şen S, Acıbucu F, Tekın A, Bülbül N, Köroğlu EY. Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature. Kafkas Journal of Medical Sciences. 2023;13(1):78-81. https://izlik.org/JA67BY65CA

Chicago

Şen, Suat, Fettah Acıbucu, Asım Tekın, Neşe Bülbül, and Ekin Yiğit Köroğlu. 2023. “Review of Clinical and Laboratory Findings of Patients With Primary Hyperparathyroidism by the Literature”. Kafkas Journal of Medical Sciences 13 (1): 78-81. https://izlik.org/JA67BY65CA.

EndNote

Şen S, Acıbucu F, Tekın A, Bülbül N, Köroğlu EY (April 1, 2023) Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature. Kafkas Journal of Medical Sciences 13 1 78–81.

IEEE

[1]S. Şen, F. Acıbucu, A. Tekın, N. Bülbül, and E. Y. Köroğlu, “Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature”, Kafkas Journal of Medical Sciences, vol. 13, no. 1, pp. 78–81, Apr. 2023, [Online]. Available: https://izlik.org/JA67BY65CA

ISNAD

Şen, Suat - Acıbucu, Fettah - Tekın, Asım - Bülbül, Neşe - Köroğlu, Ekin Yiğit. “Review of Clinical and Laboratory Findings of Patients With Primary Hyperparathyroidism by the Literature”. Kafkas Journal of Medical Sciences 13/1 (April 1, 2023): 78-81. https://izlik.org/JA67BY65CA.

JAMA

1.Şen S, Acıbucu F, Tekın A, Bülbül N, Köroğlu EY. Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature. Kafkas Journal of Medical Sciences. 2023;13:78–81.

MLA

Şen, Suat, et al. “Review of Clinical and Laboratory Findings of Patients With Primary Hyperparathyroidism by the Literature”. Kafkas Journal of Medical Sciences, vol. 13, no. 1, Apr. 2023, pp. 78-81, https://izlik.org/JA67BY65CA.

Vancouver

1.Suat Şen, Fettah Acıbucu, Asım Tekın, Neşe Bülbül, Ekin Yiğit Köroğlu. Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature. Kafkas Journal of Medical Sciences [Internet]. 2023 Apr. 1;13(1):78-81. Available from: https://izlik.org/JA67BY65CA