Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature

Suat Şen; Fettah Acıbucu; Asım Tekın; Neşe Bülbül; Ekin Yiğit Köroğlu

Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature

Öz

Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by hypercalcemia and a high or normal parathyroid hormone (PTH) level inconsistent with calcium. Complications caused by hypercalcemia or excess PTH in patients affect many systems. Therefore, early diagnosis of PHPT can help prevent complications and determine the treatment. Method: In our study, a total of 154 patients, 122 women and 32 men, who were diagnosed with PHPT in the Endocrinology outpatient clinic were retrospectively reviewed and evaluated in the light of the literature. Results: The mean age of the patients was 53.83±13.80 years. Detected mean values for calcium were 11.83±1.28 mg/dl, for phosphorus 2.47±0.57 mg/dl, for PTH 357.32±424.08 pg/ml, for vitamin 25OH D₃ 16.58±9.57 ng/ml, for estimated glomerular filtration rate (eGFR) was 99.03±23.84 ml/min/1.7 and for urinary calcium amount was 381.80±204.11 mg/24h. Bone mineral density (BMD) measurements were made in 64.3% (n: 99) of the patients, 38.4 % (n: 38) had osteopenia, and 42.4 % (n: 42) had osteoporosis. A history of urinary stones was found in 35.7% (n: 55) of the patients, and stone findings were found on ultrasonography in 36.1 % (n: 35). In total, 37% (n: 57) of the cases developed nephrolithiasis as a complication. In the localization study, adenoma was detected in 76.8% (n: 116) of the patients by ultrasonography, while 70.7% (n: 106) were found positive by Tc99 sestamibi scan. The lower right part was the most commonly detected adenoma localization in both imaging. In the pathology results of the operated patients, 91.5% (n: 118) were reported as adenomas. In the follow-up of the operated patients, recurrence was detected in 4.6% (n: 6). Conclusion: Early diagnosis and treatment of PHPT are important to prevent serious complications. The absence of serious complications in the cases in our study shows the importance of early diagnosis.

Anahtar Kelimeler

Kaynakça

1. Marcella D. Walker and Shonni J. Silverberg. Primary hyperparathyroidism. Nat Rev Endocrinol. 2018; 14(2):115–25.
2. Mehmet Uludağ, Nurcihan Aygün. Primer Hiperparatiroidi; Klinik ve Biyokimyasal Bulguların Güncel Durumu Şişli Etfal Hastanesi Tip Bülteni-2016; 50(3):171–80.
3. Aysen Akalın, Özlem Zeynep Akyay, Metin Alış, Betül Altun, Dilek Karakaya Arpacı, Ayşegül Atmaca ve ark. Türkiye Endokrinoloji ve Metabolizma Derneği Osteoporoz ve Metabolik Kemik Hastalıkları Tanı ve Tedavi Kılavuzu Primer Hiperparatiroidizm. 2020:145–53.
4. Karel Dandurand, Dalal S Ali, Aliya A Khan. Primary Hyperparathyroidism: A Narrative Review of Diagnosis and Medical Management. 2021;10(8):1604.
5. Liuping Chen, Yaling Pan, Fangyuan Zhong, Tian-Jiao Yuan, Hanqi Wang, Tongtong Chen, et al. Using QCT to evaluate bone mineral and abdominal adipose changes in patients with primary hyperparathyroidism and comparing it to DXA for bone status assessment: a retrospective case-control study. 2022; 10(10):606.
6. Cipriani C, Biamonte F, Costa AG, Zhang C, Biondi P, Diacinti D, et al. Prevalence of Kidney Stones And Vertebral Fractures in Primary Hyperparathyroidism Using Imaging Technology. J Clin Endocrinol Metab. 2015; 100:1309–15.
7. H Lowe, DJ McMahon, Bay Rubin, JP Bilezikian, SJ Silverberg. Normocalcemic primary hyperparathyroidism: Further characterization of a new clinical phenotype. J Clin Endocrinol Metab. 2007; 92:3001–5.
8. Maqsood Khan, Alvin Jose, Sandeep Sharma. Physiology, Parathyroid Hormone. 2022 Jan. 2022 Oct 29.

Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Suat Şen Bu kişi benim
Türkiye

Fettah Acıbucu Bu kişi benim
Türkiye

Asım Tekın Bu kişi benim
Türkiye

Neşe Bülbül Bu kişi benim
Türkiye

Ekin Yiğit Köroğlu Bu kişi benim
Türkiye

Yayımlanma Tarihi

26 Nisan 2023

Gönderilme Tarihi

20 Eylül 2022

Kabul Tarihi

12 Şubat 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 13 Sayı: 1

IZ

https://izlik.org/JA67BY65CA

Kaynak Göster

RIS / Bibtex

APA

Şen, S., Acıbucu, F., Tekın, A., Bülbül, N., & Köroğlu, E. Y. (2023). Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature. Kafkas Journal of Medical Sciences, 13(1), 78-81. https://izlik.org/JA67BY65CA

AMA

1.Şen S, Acıbucu F, Tekın A, Bülbül N, Köroğlu EY. Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature. KAFKAS TIP BİL DERG. 2023;13(1):78-81. https://izlik.org/JA67BY65CA

Chicago

Şen, Suat, Fettah Acıbucu, Asım Tekın, Neşe Bülbül, ve Ekin Yiğit Köroğlu. 2023. “Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature”. Kafkas Journal of Medical Sciences 13 (1): 78-81. https://izlik.org/JA67BY65CA.

EndNote

Şen S, Acıbucu F, Tekın A, Bülbül N, Köroğlu EY (01 Nisan 2023) Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature. Kafkas Journal of Medical Sciences 13 1 78–81.

IEEE

[1]S. Şen, F. Acıbucu, A. Tekın, N. Bülbül, ve E. Y. Köroğlu, “Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature”, KAFKAS TIP BİL DERG, c. 13, sy 1, ss. 78–81, Nis. 2023, [çevrimiçi]. Erişim adresi: https://izlik.org/JA67BY65CA

ISNAD

Şen, Suat - Acıbucu, Fettah - Tekın, Asım - Bülbül, Neşe - Köroğlu, Ekin Yiğit. “Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature”. Kafkas Journal of Medical Sciences 13/1 (01 Nisan 2023): 78-81. https://izlik.org/JA67BY65CA.

JAMA

1.Şen S, Acıbucu F, Tekın A, Bülbül N, Köroğlu EY. Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature. KAFKAS TIP BİL DERG. 2023;13:78–81.

MLA

Şen, Suat, vd. “Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature”. Kafkas Journal of Medical Sciences, c. 13, sy 1, Nisan 2023, ss. 78-81, https://izlik.org/JA67BY65CA.

Vancouver

1.Suat Şen, Fettah Acıbucu, Asım Tekın, Neşe Bülbül, Ekin Yiğit Köroğlu. Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature. KAFKAS TIP BİL DERG [Internet]. 01 Nisan 2023;13(1):78-81. Erişim adresi: https://izlik.org/JA67BY65CA