Kalsiyum Kanal Blokerlerinin Pleiotropik Etkileri

Şerife Canbolat; Kısmet Esra Nurullahoğlu Atalık

Kalsiyum Kanal Blokerlerinin Pleiotropik Etkileri

Abstract

Kalsiyum kanal blokerleri, hipertansiyon, angina, periferik vasküler bozukluklar ve bazı aritmiler gibi kardiyovasküler hastalıkların tedavisinde yaygın olarak kullanılan bir ilaç grubudur. Kalsiyum kanal blokerlerinden özellikle daha yeni, daha uzun etkili olanlar, daha düşük yan etki profilleri ile hipertansiyon tedavisinde oldukça etkilidir. Bu ilaçlar, damar düz kası ve kalp hücrelerinde, sitoplazma membranındaki voltaj-bağımlı kalsiyum kanallarına veya reseptörlere yüksek afinite ile bağlanarak kalsiyum girişini azaltırlar, özellikle arteriyollerde düz kasları gevşeterek güçlü vazodilatasyon yaparlar. Voltaj-bağımlı kalsiyum kanallarının çoğunlukla L-tipine bağlanırlar. Yakın zamanda yapılan çalışmalar, bazı kalsiyum kanal blokerlerinin N- ve T-tipi kanallara da bağlandığını göstermiştir. Bunlardan N-tipi kanallar sempatik sinir uçlarında, T-tipi kanallar ise kardiyak sinus nodu ile afferent ve efferent arteriyollerde bulunur. Bu iki tip kanalın blokajı, glomerüler kapiller basıncın azalmasına, renin-anjiotensin-aldosteron sisteminin ve sempatik sinir sisteminin stabilizasyonuna neden olur. Sonuçta, özellikle yeni jenerasyon kalsiyum kanal blokerleri, renoprotektif, vasküler endotel koruyucu etki ve kardiyoprotektif etkiler gibi pleiotropik etkiler olarak tanımlananan etkilere sahiptirler.

Keywords

kalsiyum; blokör; pleiotropik etkiler

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Details

Primary Language

Turkish

Subjects

Clinical Sciences

Journal Section

Review

Authors

Şerife Canbolat This is me
Türkiye

Kısmet Esra Nurullahoğlu Atalık This is me
Türkiye

Publication Date

August 1, 2019

Submission Date

December 10, 2018

Acceptance Date

April 24, 2019

Published in Issue

Year 2019 Volume: 9 Number: 2

IZ

https://izlik.org/JA32LG85BC

Cite

RIS / Bibtex

APA

Canbolat, Ş., & Nurullahoğlu Atalık, K. E. (2019). Kalsiyum Kanal Blokerlerinin Pleiotropik Etkileri. Kafkas Journal of Medical Sciences, 9(2), 125-131. https://izlik.org/JA32LG85BC

AMA

1.Canbolat Ş, Nurullahoğlu Atalık KE. Kalsiyum Kanal Blokerlerinin Pleiotropik Etkileri. Kafkas Journal of Medical Sciences. 2019;9(2):125-131. https://izlik.org/JA32LG85BC

Chicago

Canbolat, Şerife, and Kısmet Esra Nurullahoğlu Atalık. 2019. “Kalsiyum Kanal Blokerlerinin Pleiotropik Etkileri”. Kafkas Journal of Medical Sciences 9 (2): 125-31. https://izlik.org/JA32LG85BC.

EndNote

Canbolat Ş, Nurullahoğlu Atalık KE (August 1, 2019) Kalsiyum Kanal Blokerlerinin Pleiotropik Etkileri. Kafkas Journal of Medical Sciences 9 2 125–131.

IEEE

[1]Ş. Canbolat and K. E. Nurullahoğlu Atalık, “Kalsiyum Kanal Blokerlerinin Pleiotropik Etkileri”, Kafkas Journal of Medical Sciences, vol. 9, no. 2, pp. 125–131, Aug. 2019, [Online]. Available: https://izlik.org/JA32LG85BC

ISNAD

Canbolat, Şerife - Nurullahoğlu Atalık, Kısmet Esra. “Kalsiyum Kanal Blokerlerinin Pleiotropik Etkileri”. Kafkas Journal of Medical Sciences 9/2 (August 1, 2019): 125-131. https://izlik.org/JA32LG85BC.

JAMA

1.Canbolat Ş, Nurullahoğlu Atalık KE. Kalsiyum Kanal Blokerlerinin Pleiotropik Etkileri. Kafkas Journal of Medical Sciences. 2019;9:125–131.

MLA

Canbolat, Şerife, and Kısmet Esra Nurullahoğlu Atalık. “Kalsiyum Kanal Blokerlerinin Pleiotropik Etkileri”. Kafkas Journal of Medical Sciences, vol. 9, no. 2, Aug. 2019, pp. 125-31, https://izlik.org/JA32LG85BC.

Vancouver

1.Şerife Canbolat, Kısmet Esra Nurullahoğlu Atalık. Kalsiyum Kanal Blokerlerinin Pleiotropik Etkileri. Kafkas Journal of Medical Sciences [Internet]. 2019 Aug. 1;9(2):125-31. Available from: https://izlik.org/JA32LG85BC