Kalsiyum Kanal Blokerlerinin Pleiotropik Etkileri

Şerife Canbolat; Kısmet Esra Nurullahoğlu Atalık

Kalsiyum Kanal Blokerlerinin Pleiotropik Etkileri

Öz

Kalsiyum kanal blokerleri, hipertansiyon, angina, periferik vasküler bozukluklar ve bazı aritmiler gibi kardiyovasküler hastalıkların tedavisinde yaygın olarak kullanılan bir ilaç grubudur. Kalsiyum kanal blokerlerinden özellikle daha yeni, daha uzun etkili olanlar, daha düşük yan etki profilleri ile hipertansiyon tedavisinde oldukça etkilidir. Bu ilaçlar, damar düz kası ve kalp hücrelerinde, sitoplazma membranındaki voltaj-bağımlı kalsiyum kanallarına veya reseptörlere yüksek afinite ile bağlanarak kalsiyum girişini azaltırlar, özellikle arteriyollerde düz kasları gevşeterek güçlü vazodilatasyon yaparlar. Voltaj-bağımlı kalsiyum kanallarının çoğunlukla L-tipine bağlanırlar. Yakın zamanda yapılan çalışmalar, bazı kalsiyum kanal blokerlerinin N- ve T-tipi kanallara da bağlandığını göstermiştir. Bunlardan N-tipi kanallar sempatik sinir uçlarında, T-tipi kanallar ise kardiyak sinus nodu ile afferent ve efferent arteriyollerde bulunur. Bu iki tip kanalın blokajı, glomerüler kapiller basıncın azalmasına, renin-anjiotensin-aldosteron sisteminin ve sempatik sinir sisteminin stabilizasyonuna neden olur. Sonuçta, özellikle yeni jenerasyon kalsiyum kanal blokerleri, renoprotektif, vasküler endotel koruyucu etki ve kardiyoprotektif etkiler gibi pleiotropik etkiler olarak tanımlananan etkilere sahiptirler.

Anahtar Kelimeler

kalsiyum; blokör; pleiotropik etkiler

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Klinik Tıp Bilimleri

Bölüm

Derleme

Yazarlar

Şerife Canbolat Bu kişi benim
Türkiye

Kısmet Esra Nurullahoğlu Atalık Bu kişi benim
Türkiye

Yayımlanma Tarihi

1 Ağustos 2019

Gönderilme Tarihi

10 Aralık 2018

Kabul Tarihi

24 Nisan 2019

Yayımlandığı Sayı

Yıl 2019 Cilt: 9 Sayı: 2

IZ

https://izlik.org/JA32LG85BC

Kaynak Göster

RIS / Bibtex

APA

Canbolat, Ş., & Nurullahoğlu Atalık, K. E. (2019). Kalsiyum Kanal Blokerlerinin Pleiotropik Etkileri. Kafkas Journal of Medical Sciences, 9(2), 125-131. https://izlik.org/JA32LG85BC

AMA

1.Canbolat Ş, Nurullahoğlu Atalık KE. Kalsiyum Kanal Blokerlerinin Pleiotropik Etkileri. KAFKAS TIP BİL DERG. 2019;9(2):125-131. https://izlik.org/JA32LG85BC

Chicago

Canbolat, Şerife, ve Kısmet Esra Nurullahoğlu Atalık. 2019. “Kalsiyum Kanal Blokerlerinin Pleiotropik Etkileri”. Kafkas Journal of Medical Sciences 9 (2): 125-31. https://izlik.org/JA32LG85BC.

EndNote

Canbolat Ş, Nurullahoğlu Atalık KE (01 Ağustos 2019) Kalsiyum Kanal Blokerlerinin Pleiotropik Etkileri. Kafkas Journal of Medical Sciences 9 2 125–131.

IEEE

[1]Ş. Canbolat ve K. E. Nurullahoğlu Atalık, “Kalsiyum Kanal Blokerlerinin Pleiotropik Etkileri”, KAFKAS TIP BİL DERG, c. 9, sy 2, ss. 125–131, Ağu. 2019, [çevrimiçi]. Erişim adresi: https://izlik.org/JA32LG85BC

ISNAD

Canbolat, Şerife - Nurullahoğlu Atalık, Kısmet Esra. “Kalsiyum Kanal Blokerlerinin Pleiotropik Etkileri”. Kafkas Journal of Medical Sciences 9/2 (01 Ağustos 2019): 125-131. https://izlik.org/JA32LG85BC.

JAMA

1.Canbolat Ş, Nurullahoğlu Atalık KE. Kalsiyum Kanal Blokerlerinin Pleiotropik Etkileri. KAFKAS TIP BİL DERG. 2019;9:125–131.

MLA

Canbolat, Şerife, ve Kısmet Esra Nurullahoğlu Atalık. “Kalsiyum Kanal Blokerlerinin Pleiotropik Etkileri”. Kafkas Journal of Medical Sciences, c. 9, sy 2, Ağustos 2019, ss. 125-31, https://izlik.org/JA32LG85BC.

Vancouver

1.Şerife Canbolat, Kısmet Esra Nurullahoğlu Atalık. Kalsiyum Kanal Blokerlerinin Pleiotropik Etkileri. KAFKAS TIP BİL DERG [Internet]. 01 Ağustos 2019;9(2):125-31. Erişim adresi: https://izlik.org/JA32LG85BC