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Anti-TPO Yüksekliği Olan Ötiroid ve Hipotiroidili Hastalarda Vitamin D Düzeyleri ile Tiroid Fonksiyon Testleri Arasındaki İlişki

Year 2019, Volume: 9 Issue: 3, 158 - 161, 01.12.2019

Lütfiye Seçil Deniz Balyen

Abstract

Amaç: Otoimmun tiroid hastalıkları (AITD) ile vitamin D seviyeleri arasındaki ilişkiyi araştıran çalışmaların sonuçları tutarsızdır. Bizim çalışmamızın amacı, tiroid peroksidaz antikorları (anti-TPO) yükselmiş olan hipotiroid veya ötiroid hastalarda vitamin D seviyeleri ile tiroid fonksiyon testleri arasındaki ilişkiyi değerlendirmekti.
Materyal ve Metot: Bu çalışma, anti-TPO pozitifliği saptanan ve vitamin D seviyeleri ile tiroid fonksiyon testleri eş zamanlı olarak ölçülen 21 hastanın dosya kayıtları incelenerek gerçekleştirildi. Katılımcılar vitamin D seviyelerine göre 2 gruba ayrıldı: grup 1 (optimal vitamin D seviyelerine (≥20 ng/mL) sahip olan hastalar) ve grup 2 (yetersiz veya eksik vitamin D seviyelerine (<20 ng/mL) sahip olan hastalar). Bulgular: Anti-TPO seviyeleri (median (min-max)) grup 1’de (149.3 (29.7-388.1) IU/mL), grup 2’dekine göre (287.7 (141.5-794.6) IU/ mL) daha düşüktü (p=0.036). Tiroid stimulan hormon (TSH) ve serbest tiroksin (fT4) seviyeleri gruplar arasında farklı değildi. Anti-TPO seviyeleri TSH ile pozitif olarak (r=0.731, p= 0.005), vitamin D ile negatif olarak (r=-0.484, p=0.026) korele idi. Sonuç: Düşük vitamin D seviyeleri AITD’lerin patogenezine katkıda bulunabilir veya bir nedenden ziyade otoimmun hastalık sürecinin bir sonucu olabilir. Otoimmun tiroiditte vitamin D seviyelerinin rolünü tam olarak aydınlatabilmek için daha ileri araştırmalar gereklidir

Keywords

vitamin D; otoimmun tiroidit; tiroid fonksiyon testleri

References

  • 1. Chaker L, Bianco AC, Jonklaas J, Peeters RP. Hypothyroidism. Lancet 2017;390(10101):1550–62.
  • 2. Mincer DL. Thyroid, Hashimoto thyroiditis. Treasure Island (FL): StatPearls Publishing; 2017.
  • 3. Krysiak R, Szkrobka W, Okopien B. The effect of vitamin D and elenomethionine on thyroid antibody titers, hypothalamicpituitary-thyroid axis activity and thyroid function tests in men with Hashimoto’s thyroiditis: A pilot study. Pharmacol Rep 2019;71(2):243–7.
  • 4. Krysiak R, Kowalcze K, Okopien B. The effect of vitamin D on thyroid autoimmunity in euthyroid men with autoimmune thyroiditis and testosterone deficiency. Pharmacol Rep 2019;71(5):798–803.
  • 5. Wiersinga WM. Clinical relevance of environmental factors in the pathogenesis of autoimmune thyroid disease. Endocrinol Metab (Seoul)2016;31(2):213–22.
  • 6. Kmiec P, Sworczak K. Vitamin D in thyroid disorders. Exp Clin Endocrinol Diabetes 2015;123(7):386–93.
  • 7. Erdoğdu Hİ, Atalay E. Relationship between high erythrocyte sedimentation rate and 25-hydroxy vitamin D and C-reactive protein levels. Sakarya Med J 2018;8:798–805.
  • 8. Botelho IMB, Moura Neto A, Silva CA, Tambascia MA, Alegre SM, Zantut-Wittmann DE. Vitamin D in Hashimoto’s thyroiditis and its relationship with thyroid function and inflammatory status. Endocr J 2018;65(10):1029–37.
  • 9. Thacher TD, Clarke BL. Vitamin D insufficiency. Mayo Clin Proc 2011;86(1):50–60.
  • 10. Ruf J, Carayon P. Structural and functional aspects of thyroid peroxidase. Arch Biochem Biophys 2006;445(2):269–77.
  • 11. Wiersinga WM. Thyroid autoimmunity. Endocr Dev 2014;26:139–57.
  • 12. Wimalawansa SJ, Razzaque DMS, Al-Daghri NM. Calcium and vitamin D in human health: hype or real? J Steroid Biochem Mol Biol 2017;S0960–0760(17):30381–3.
  • 13. Vanherwegen AS, Gysemans C, Mathieu C. Regulation of immune function by vitamin D and its use in diseases of immunity. Endocrinol Metab Clin North Am 2017;46(4):1061–94.
  • 14. Nalbant A, Aydin A, Karacan A, Onmez A, Tamer A, Cinemre H. Association of vitamin D insufficiency/deficiency with thyroid artery Doppler ultrasonography in patients with Hashimoto thyroiditis. Pak J Med Sci 2017;33(2):295–9.
  • 15. Palmer MT, Lee YK, Maynard CL, Oliver JR, Bikle DD, Jetten AM, et al. Lineage-specific effects of 1, 25-dihydroxyvitamin D(3)on the development of effector CD4 T cells. J Biol Chem 2011;286(2):997–1004.
  • 16. Wang J, Lv S, Chen G, Gao C, He J, Zhong H, et al. Metaanalysis of the association between vitamin D and autoimmune thyroid disease. Nutrients 2015;7(4):2485–98.
  • 17. Feng M, Li H, Chen SF, Li WF, Zhang FB. Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis. Endocrine 2013;43(2):318–26.
  • 18. Wang X, Zynat J, Guo Y, Osiman R, Tuhuti A, Zhao H, et al. Low serum vitamin d is associated with anti-thyroidglobulin antibody in female individuals. Int J Endocrinol 2015;2015:285290.
  • 19. Lacka K, Maciejewski A. Vitamin D in the etiopathogenesis of autoimmune thyroiditis. Pol Merkur Lekarski 2013;34(203):281–5.
  • 20. Simsek Y, Cakır I, Yetmis M, Dizdar OS, Baspinar O, Gokay F. Effects of vitamin D treatment on thyroid autoimmunity. J Res Med Sci 2016;21:85.
  • 21. Anaraki PV, Aminorroaya A, Amini M, Feizi A, Iraj B, Tabatabaei A. Effects of Vitamin D deficiency treatment on metabolic markers in Hashimoto thyroiditis patients. J Res Med Sci 2017;22:5.
  • 22. Vahabi Anaraki P, Aminorroaya A, Amini M, Momeni F, Feizi A, Iraj B, et al. Effect of vitamin D deficiency treatment on thyroid function and autoimmunity markers in Hashimoto’s thyroiditis: A double-blind randomized placebo-controlled clinical trial. J Res Med Sci 2017;22:103.
  • 23. Vondra K, Bilek R, Matucha P, Salatova M, Vosatkova M, Starka L, et al. Vitamin D supplementation changed relationships, not levels of metabolic-hormonal parameters in autoimmune thyroiditis. Physiol Res 2017;66(Supplementum 3): S409-S417.
  • 24. Hu S, Rayman MP. Multiple nutritional factors and the risk of hashimoto’s thyroiditis. Thyroid 2017; 27(5):597–610.

Year 2019, Volume: 9 Issue: 3, 158 - 161, 01.12.2019

Lütfiye Seçil Deniz Balyen

Abstract

References

  • 1. Chaker L, Bianco AC, Jonklaas J, Peeters RP. Hypothyroidism. Lancet 2017;390(10101):1550–62.
  • 2. Mincer DL. Thyroid, Hashimoto thyroiditis. Treasure Island (FL): StatPearls Publishing; 2017.
  • 3. Krysiak R, Szkrobka W, Okopien B. The effect of vitamin D and elenomethionine on thyroid antibody titers, hypothalamicpituitary-thyroid axis activity and thyroid function tests in men with Hashimoto’s thyroiditis: A pilot study. Pharmacol Rep 2019;71(2):243–7.
  • 4. Krysiak R, Kowalcze K, Okopien B. The effect of vitamin D on thyroid autoimmunity in euthyroid men with autoimmune thyroiditis and testosterone deficiency. Pharmacol Rep 2019;71(5):798–803.
  • 5. Wiersinga WM. Clinical relevance of environmental factors in the pathogenesis of autoimmune thyroid disease. Endocrinol Metab (Seoul)2016;31(2):213–22.
  • 6. Kmiec P, Sworczak K. Vitamin D in thyroid disorders. Exp Clin Endocrinol Diabetes 2015;123(7):386–93.
  • 7. Erdoğdu Hİ, Atalay E. Relationship between high erythrocyte sedimentation rate and 25-hydroxy vitamin D and C-reactive protein levels. Sakarya Med J 2018;8:798–805.
  • 8. Botelho IMB, Moura Neto A, Silva CA, Tambascia MA, Alegre SM, Zantut-Wittmann DE. Vitamin D in Hashimoto’s thyroiditis and its relationship with thyroid function and inflammatory status. Endocr J 2018;65(10):1029–37.
  • 9. Thacher TD, Clarke BL. Vitamin D insufficiency. Mayo Clin Proc 2011;86(1):50–60.
  • 10. Ruf J, Carayon P. Structural and functional aspects of thyroid peroxidase. Arch Biochem Biophys 2006;445(2):269–77.
  • 11. Wiersinga WM. Thyroid autoimmunity. Endocr Dev 2014;26:139–57.
  • 12. Wimalawansa SJ, Razzaque DMS, Al-Daghri NM. Calcium and vitamin D in human health: hype or real? J Steroid Biochem Mol Biol 2017;S0960–0760(17):30381–3.
  • 13. Vanherwegen AS, Gysemans C, Mathieu C. Regulation of immune function by vitamin D and its use in diseases of immunity. Endocrinol Metab Clin North Am 2017;46(4):1061–94.
  • 14. Nalbant A, Aydin A, Karacan A, Onmez A, Tamer A, Cinemre H. Association of vitamin D insufficiency/deficiency with thyroid artery Doppler ultrasonography in patients with Hashimoto thyroiditis. Pak J Med Sci 2017;33(2):295–9.
  • 15. Palmer MT, Lee YK, Maynard CL, Oliver JR, Bikle DD, Jetten AM, et al. Lineage-specific effects of 1, 25-dihydroxyvitamin D(3)on the development of effector CD4 T cells. J Biol Chem 2011;286(2):997–1004.
  • 16. Wang J, Lv S, Chen G, Gao C, He J, Zhong H, et al. Metaanalysis of the association between vitamin D and autoimmune thyroid disease. Nutrients 2015;7(4):2485–98.
  • 17. Feng M, Li H, Chen SF, Li WF, Zhang FB. Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis. Endocrine 2013;43(2):318–26.
  • 18. Wang X, Zynat J, Guo Y, Osiman R, Tuhuti A, Zhao H, et al. Low serum vitamin d is associated with anti-thyroidglobulin antibody in female individuals. Int J Endocrinol 2015;2015:285290.
  • 19. Lacka K, Maciejewski A. Vitamin D in the etiopathogenesis of autoimmune thyroiditis. Pol Merkur Lekarski 2013;34(203):281–5.
  • 20. Simsek Y, Cakır I, Yetmis M, Dizdar OS, Baspinar O, Gokay F. Effects of vitamin D treatment on thyroid autoimmunity. J Res Med Sci 2016;21:85.
  • 21. Anaraki PV, Aminorroaya A, Amini M, Feizi A, Iraj B, Tabatabaei A. Effects of Vitamin D deficiency treatment on metabolic markers in Hashimoto thyroiditis patients. J Res Med Sci 2017;22:5.
  • 22. Vahabi Anaraki P, Aminorroaya A, Amini M, Momeni F, Feizi A, Iraj B, et al. Effect of vitamin D deficiency treatment on thyroid function and autoimmunity markers in Hashimoto’s thyroiditis: A double-blind randomized placebo-controlled clinical trial. J Res Med Sci 2017;22:103.
  • 23. Vondra K, Bilek R, Matucha P, Salatova M, Vosatkova M, Starka L, et al. Vitamin D supplementation changed relationships, not levels of metabolic-hormonal parameters in autoimmune thyroiditis. Physiol Res 2017;66(Supplementum 3): S409-S417.
  • 24. Hu S, Rayman MP. Multiple nutritional factors and the risk of hashimoto’s thyroiditis. Thyroid 2017; 27(5):597–610.
There are 24 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research Article
Authors

Lütfiye Seçil Deniz Balyen This is me

Publication Date December 1, 2019
Published in Issue Year 2019 Volume: 9 Issue: 3

Cite

APA Deniz Balyen, L. S. (2019). Anti-TPO Yüksekliği Olan Ötiroid ve Hipotiroidili Hastalarda Vitamin D Düzeyleri ile Tiroid Fonksiyon Testleri Arasındaki İlişki. Kafkas Journal of Medical Sciences, 9(3), 158-161.
AMA Deniz Balyen LS. Anti-TPO Yüksekliği Olan Ötiroid ve Hipotiroidili Hastalarda Vitamin D Düzeyleri ile Tiroid Fonksiyon Testleri Arasındaki İlişki. KAFKAS TIP BİL DERG. December 2019;9(3):158-161.
Chicago Deniz Balyen, Lütfiye Seçil. “Anti-TPO Yüksekliği Olan Ötiroid Ve Hipotiroidili Hastalarda Vitamin D Düzeyleri Ile Tiroid Fonksiyon Testleri Arasındaki İlişki”. Kafkas Journal of Medical Sciences 9, no. 3 (December 2019): 158-61.
EndNote Deniz Balyen LS (December 1, 2019) Anti-TPO Yüksekliği Olan Ötiroid ve Hipotiroidili Hastalarda Vitamin D Düzeyleri ile Tiroid Fonksiyon Testleri Arasındaki İlişki. Kafkas Journal of Medical Sciences 9 3 158–161.
IEEE L. S. Deniz Balyen, “Anti-TPO Yüksekliği Olan Ötiroid ve Hipotiroidili Hastalarda Vitamin D Düzeyleri ile Tiroid Fonksiyon Testleri Arasındaki İlişki”, KAFKAS TIP BİL DERG, vol. 9, no. 3, pp. 158–161, 2019.
ISNAD Deniz Balyen, Lütfiye Seçil. “Anti-TPO Yüksekliği Olan Ötiroid Ve Hipotiroidili Hastalarda Vitamin D Düzeyleri Ile Tiroid Fonksiyon Testleri Arasındaki İlişki”. Kafkas Journal of Medical Sciences 9/3 (December 2019), 158-161.
JAMA Deniz Balyen LS. Anti-TPO Yüksekliği Olan Ötiroid ve Hipotiroidili Hastalarda Vitamin D Düzeyleri ile Tiroid Fonksiyon Testleri Arasındaki İlişki. KAFKAS TIP BİL DERG. 2019;9:158–161.
MLA Deniz Balyen, Lütfiye Seçil. “Anti-TPO Yüksekliği Olan Ötiroid Ve Hipotiroidili Hastalarda Vitamin D Düzeyleri Ile Tiroid Fonksiyon Testleri Arasındaki İlişki”. Kafkas Journal of Medical Sciences, vol. 9, no. 3, 2019, pp. 158-61.
Vancouver Deniz Balyen LS. Anti-TPO Yüksekliği Olan Ötiroid ve Hipotiroidili Hastalarda Vitamin D Düzeyleri ile Tiroid Fonksiyon Testleri Arasındaki İlişki. KAFKAS TIP BİL DERG. 2019;9(3):158-61.