QTL Analysis Methods
Abstract
In recent years, quantitative characters have settled to a quite important place among genetic studies. The inheritance of these traits is usually achieved by multiple gene expression and by the additive and interactive effects of these genes. Therefore, the analysis methods used to understand the genetic basis of quantitative traits may be more complex than those of qualitative traits. The loci on the chromosome at which the genes controlling the genetic architecture of the quantitative traits are located are called the quantitative trait loci (QTL). There are different methods for detecting and analyzing the presence of these loci. In addition, it is possible to map the QTLs with the help of the molecular markers as a developing method thanks to today's technology. In this review, the methods of diagnosing QTL and mapping studies were analyzed.
Keywords
References
- [1] W. R. Doerge, “Mapping and analysis of quantitative trait loci in experimental populations,” Nature, vol. 3, pp. 43-52, Jan. 2002. DOI: 10.1038/nrg703
- [2] D. S. M. Falconer and T. F. C. Mackay, “Quantitative trait loci” in Introduction To Quantitative Genetics, 4th ed., Essex, England, 1996, pp. 356-377.
- [3] H. Geldermann, “Investigations on inheritance of quantitative characters in animals by gene markers I. methods,” Theoretical and Applied Genetics, vol. 46, no. 7, pp. 319-330, 1975.
- [4] C.S. Haley and S.A. Knott, “A simple regression method for mapping quantitative trait loci in line crosses using flanking markers,” Heredity, vol. 69, pp. 315-324, 1992.
- [5] B. İşçi, “Asmada QTL (kantitatif karakter lokus) analizi,” Anadolu (Journal of Aegean Agricultural Research Institute), vol. 18, no. 2, pp. 11-37, 2008.
- [6] R. C. Jansen, “Interval mapping of multiple quantitative trait loci,” Genetics, vol. 135, pp. 205-211, Sep. 1993.
- [7] R. C. Jansen, D. L. Johnson and J. A. M. Van Arendonk, “A mixture model approach to the mapping of quantitative trait loci in complex populations with an application to multiple cattle families,” Genetics, vol. 148, pp. 391-399, Jan. 1998.
- [8] O. Kavuncu, “İstatistik Teorisi ve Teorik Dağılımlar”, Ankara, Turkey, 1995.
Details
Primary Language
English
Subjects
-
Journal Section
Review
Publication Date
June 27, 2019
Submission Date
May 13, 2019
Acceptance Date
May 22, 2019
Published in Issue
Year 2019 Volume: 5 Number: 1