Synthesis of Some New 1,2,4‐Triazole‐3‐one Derivatives and Investigation of Biological Activity
Abstract
Schiff bases have excellent characteristics, structural similarities with natural biological agents and synthetic flexibility. Schiff base-bimolecular condensation products with aldehydes of primary amines represent valuable intermediates in organic synthesis. Schiff bases derived from salicylaldehyde have been reported to have plant growth regulator, antimicrobial or antimycotic activity. In studies describing the relationship between quantitative structure-antitumor activity of a series of Schiff bases, Salicyldehydes have been shown to provide the best correlation in the ligands. In this study, 6 new Schiff bases were synthesized from the reaction of the substituted amino compounds with 5-bromosalicylaldehyde and their structures were illuminated spectroscopic data. The biological activities of this compound series were evaluated. The results show that the novel compounds synthesized have effective antioxidant and antiurease activities.
Keywords
1 2 4‐Triazole‐3‐one, 5-Bromosalicylaldehyde, Amino Compounds, Antioxidant Activity, Antiurease Activity
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