Bazı Yeni 1,2,4‐Triazole‐3‐on Türevlerinin Sentezi ve Biyolojik Aktivitelerinin İncelenmesi

Year 2018, , 171 - 180, 31.12.2018

Nurhan Gümrükçüoğlu , Bahar Bilgin Sökmen

https://doi.org/10.31466/kfbd.481807

Abstract

Schiff bazları mükemmel karakteristikliğe, doğal biyolojik maddelerle yapısal benzerliklere ve sentetik esnekliğe sahiptirler. Primer aminlerin aldehidler ile Schiff baz-bimoleküler kondenzasyon ürünleri, organik sentezde değerli ara maddeleri temsil eder. Salisilaldehitden türeyen Schiff bazlarının bitki büyüme düzenleyici, antimikrobiyen veya antimikotik aktivitesi olduğu bildirilmiştir. Bir dizi Schiff bazının kantitatif yapı-antitümör aktivite ilişkisini açıklayan çalışmalarda, salisilaldehitlerden elde edilen ligandlarda en iyi korelasyonun sağlandığı gösterilmiştir. Bu çalışmada substitue amino bileşiklerinin 5-Bromosalisilaldehit ile reaksiyonundan 6 yeni Schiff bazları sentezlendi ve yapıları, spektroskopik verilerle aydınlatıldı. Bu bileşik serisinin biyolojik aktiviteleri değerlendirildi. Sonuçlar, sentezlenen yeni bileşiklerin etkili antioksidan ve antiüreaz aktiviteye sahip olduğunu göstermektedir.

Keywords

1 2 4‐Triazole‐3‐on, 5-Bromosalisilaldehit, Amino Bileşikleri, Antioksidan Aktivite, Antiüreaz Aktivite

Synthesis of Some New 1,2,4‐Triazole‐3‐one Derivatives and Investigation of Biological Activity

Abstract

Schiff bases have excellent characteristics, structural similarities with natural biological agents and synthetic flexibility. Schiff base-bimolecular condensation products with aldehydes of primary amines represent valuable intermediates in organic synthesis. Schiff bases derived from salicylaldehyde have been reported to have plant growth regulator, antimicrobial or antimycotic activity. In studies describing the relationship between quantitative structure-antitumor activity of a series of Schiff bases, Salicyldehydes have been shown to provide the best correlation in the ligands. In this study, 6 new Schiff bases were synthesized from the reaction of the substituted amino compounds with 5-bromosalicylaldehyde and their structures were illuminated spectroscopic data. The biological activities of this compound series were evaluated. The results show that the novel compounds synthesized have effective antioxidant and antiurease activities.

Keywords

1 2 4‐Triazole‐3‐one, 5-Bromosalicylaldehyde, Amino Compounds, Antioxidant Activity, Antiurease Activity

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