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Hindistan Cevizi Yağının Travmatik Beyin Hasarı Olan Farelerde Nöroprotektif Etkisi

Year 2021, Volume: 16 Issue: 2, 236 - 240, 07.07.2021
https://doi.org/10.17517/ksutfd.853830
https://izlik.org/JA48MZ93JR

Abstract

Amaç: Bu çalışmada hindistan cevizi yağının travmatik beyin hasarı olan farelerde olası nöroprotektif etkisini değerlendirmeyi amaçladık.
Materyal ve Metod: Fareler rastgele iki gruba ayrıldı (grup başına n = 5); diğer bir deyişle, kontrol ve Hindistan cevizi yağı grubu; sırasıyla soğuk beyin hasarından önce bir hafta boyunca 250 ul salin ve her bir os hindistancevizi yağı başına 10 mg / kg vücut ağırlığına göre belirlendi. Beyindeki enfarktüs ve ödem hacmi yaralanmadan 24 saat sonra sekizinci günde iki grupta Kresil Moru ile ölçüldü.
Bulgular: Verilerimiz, hindistancevizi yağı uygulamasından sonra enfarktüs ve ödem hacimlerinde istatistiksel olarak anlamlı bir düşüş olduğunu gösterdi.
Sonuç: Bulgularımız, hindistancevizi yağının farelerde travmatik beyin hasarı sonrası hasarlı nöronlar üzerinde potansiyel bir nöroprotektif etkiye sahip olduğunu desteklemiştir.

References

  • 1.Fernando WMADB, Martins IJ, Goozee K, Brennan CS, Jayasena V, Martins RN. The role of dietary coconut for the prevention and treatment of Alzheimer's disease: potential mechanisms of action. Br J Nutr. 2015;114(1):1-14.

The neuroprotective effect of Coconut Oil in mice with Traumatic Brain Injury

Year 2021, Volume: 16 Issue: 2, 236 - 240, 07.07.2021
https://doi.org/10.17517/ksutfd.853830
https://izlik.org/JA48MZ93JR

Abstract

Aim: This study aimed to evaluate the possible neuroprotective effect of coconut oil in mice with traumatic brain injury.
Materials and Methods: Mice were randomly divided into two groups (n=5 per group); namely, the control and coconut oil groups, which were administered 250 µl saline and 10 mg/kg body weight per os coconut oil along a week, respectively, before cold brain injury. Infarction and edema volume in the brain was measured with cresyl violet in two groups on the eighth day, 24 hours after injury.
Results: Our data indicated a statistically significant decrease in the infarct and oedema volumes after coconut oil application.
Conclusion: Our findings have supported that coconut oil has a potential neuroprotective effect on damaged neurons after traumatic brain injury in mice.

References

  • 1.Fernando WMADB, Martins IJ, Goozee K, Brennan CS, Jayasena V, Martins RN. The role of dietary coconut for the prevention and treatment of Alzheimer's disease: potential mechanisms of action. Br J Nutr. 2015;114(1):1-14.
There are 1 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research Article
Authors

Şeyda Çankaya 0000-0001-5309-0351

Mehmet Yalçın Günal 0000-0001-7702-2441

Mustafa Çağlar Beker 0000-0002-9476-8488

Ahmet Burak Çağlayan 0000-0002-6242-3709

Ekrem Musa Özdemir 0000-0001-9416-7757

Özlem Saatci 0000-0002-3372-9514

Barış Çankaya This is me 0000-0003-1635-413X

Burak Yuluğ 0000-0002-9704-6173

Submission Date January 4, 2021
Acceptance Date February 9, 2021
Publication Date July 7, 2021
DOI https://doi.org/10.17517/ksutfd.853830
IZ https://izlik.org/JA48MZ93JR
Published in Issue Year 2021 Volume: 16 Issue: 2

Cite

AMA 1.Çankaya Ş, Günal MY, Beker MÇ, et al. The neuroprotective effect of Coconut Oil in mice with Traumatic Brain Injury. KSU Medical Journal. 2021;16(2):236-240. doi:10.17517/ksutfd.853830