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Koroner Arter Hastalığı Yaygınlığı’nın RDW ile İlişkisi

Year 2022, Volume: 17 Issue: 1, 107 - 114, 21.03.2022
https://doi.org/10.17517/ksutfd.847459

Abstract

Amaç: Bu çalışmanın amacı akut koroner sendromlu (AKS) hastalarda aterosklerotik hastalığın yaygınlığını göstermek için kullanılan GENSİNİ skoru ile eritrosit dağılım hacmi arasındaki ilişkiyi araştırmaktır.
Gereç ve Yöntemler: Çalışmaya AKS tanısı ile koroner anjiografi işlemi yapılan 359 hasta alındı. Hastaların anjiografik görüntüleri analiz edilerek GENSİNİ skorları hesaplandı. Hastalar GENSİNİ skoru<20 ve ≥ 20 olmak üzere iki gruba ayrıldı. Bu iki grubun demografik, klinik ve labaratuvar parametreleri karşılaştırıldı ve GENSİNİ skor yüksekliğini predikte eden değerler araştırıldı.
Bulgular: Çalışmaya dahil edilen 359 hastanın 104 kadın hasta, 255 erkekti. GENSİNİ skoru <20 olan hastası sayısı 69 iken, GENSİNİ skoru ≥20 olan hasta sayısı 290 idi.Eritrosit Dağılım Genişliğinin (RDW) GENSİNİ SKORU ≥20 olan grupta daha yüksek olduğu görüldü.( 13.7±0.9 ve 14.2±1.4 p=0.001).Yapılan korelasyon analizinde RDW ile GENSİNİ skoru arasında pozitif korelasyon izlendi (r :0.137 p.009).Yapılan multivaryant analizde RDW nin GENSİNİ skorunun bağımsız prediktörü olduğu görüldü.( OR:1.417, %95 CI(1.037-1.935) p= 0.029)
Sonuç: AKS ile başvuran hastalarda kolay ve ulaşılabilir bir parametre olan RDW atreosklerotik kalp hastalığının şiddeti ile korele olup aterosklerotik kalp hastalığının prediktörü olarak kullanılabilir

Supporting Institution

YOK

References

  • 1. Smith JN, Negrelli JM, Manek MB, Hawes EM, Viera AJ. Diagnosis and management of acute coronary syndrome: an evidence-based update. J Am Board Fam Med. 2015;28(2):283-93.
  • 2. Makki N, Brennan TM, Girotra S. Acute coronary syndrome. J Intensive Care Med. 2015;30(4):186-200.
  • 3. Hedayati T, Yadav N, Khanagavi J. Non-ST-Segment Acute Coronary Syndromes. Cardiol Clin. 2018;36(1):37-52.
  • 4. Piironen M, Ukkola O, Huikuri H, Havulinna AS, Koukkunen H, Mustonen J, et al. Trends in long-term prognosis after acute coronary syndrome. Eur J Prev Cardiol. 2017;24(3):274-80.
  • 5. Ndrepepa G, Kastrati A, Braun S, Mehilli J, Niemöller K, von Beckerath N, et al. N-terminal probrain natriuretic peptide and C-reactive protein in stable coronary heart disease. Am J Med 2006;119(4):355.e 1-8
  • 6. Evans TC, Jehle D. The red blood cell distribution width. J Emerg Med 1991;9(1):71-4.
  • 7. Kato H, Ishida J, Imagawa S, Saito T, Suzuki N, Matsuoka T,et al. Enhanced erythropoiesis mediated by activation of the reninangiotensi system via angiotensin II type 1a receptor. FASEB J 2005;19(14):2023-5.
  • 8. Biaggioni I, Robertson D, Krantz S, Jones M, Haile V.The anemia of primary autonomic failure and its reversal with recombinant erythropoietin. Ann Intern Med 1994;121(3):181-6.
  • 9. Melchio R, Rinaldi G, Testa E, Giraudo A, Serraino C, Bracco C, et al.Red cell distribution width predicts mid-term prognosis in patients hospitalized with acute heart failure: the RDW in Acute Heart Failure (RE-AHF) study. Intern Emerg Med. 2019;14(2):239-47.
  • 10. Dai DF, Hwang JJ, Lin JL, Lin JW, Hsu CN, Lin CM, et al. Joint effects of Nterminal pro-B-type-natriuretic peptide and Creactive protein vs angiographic severity in predicting major adverse cardiovascular events and clinical restenosis after coronary angioplasty in patients with stable coronary artery disease. Circ J 2008;72(8):1316-23.
  • 11. Patel KV, Ferrucci L, Ershler WB, Longo DL, Guralnik JM. Red blood cell distribution width and the risk of death in middle-aged and older adults. Arch Intern Med 2009;169(5):515-23.
  • 12. Perlstein TS, Weuve J, Pfeffer MA, Beckman JA. Red blood cell distribution width and mortality risk in a community-based prospective cohort. Arch Intern Med 2009;169(6):588-94.
  • 13. Pascual-Figal DA, Bonaque JC, Redondo B, Caro C, Manzano-Fernandez S, Sánchez-Mas J, et al.Red blood cell distribution width predicts long-term outcome regardless of anaemia status in acute heart failure patients. Eur J Heart Fail 2009;11(9):840-6.
  • 14. Förhécz Z, Gombos T, Borgulya G, Pozsonyi Z, Prohászka Z, Jánoskuti L. Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state. Am Heart J 2009;158(4):659-66.
  • 15. A-Marsh WL, Bishop JW, Darey TP. Evaluation of red cell volume distribution width (RDW). Haematol Pathol 1987;1:117–23.
  • 16. Tonelli M, Sacks F, Arnold M, Moye L, Davis B, Pfeffer M. Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation 2008;117:163–68.
  • 17. Cavusoglu E, Chopra V, Gupta A, Battala VR, Poludasu S, Eng C,et al. Relation between red blood cell distribution width (RDW) and all-cause mortality at two years in an unselected population referred for coronary angiography. Int J Cardiol. 2010 28;141(2):141-46
  • 18. Felker GM, Allen LA, Pocock SJ, Shaw LK, McMurray JJ, Pfeffer MA, et al.CHARM Investigators. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. J Am Coll Cardiol. 2007;50(1):40-7
  • 19. Warwick R, Mediratta N, Shaw M, McShane J, Pullan M, Chalmers J, et al.Red cell distribution width and coronary artery bypass surgery. Eur J Cardiothorac Surg. 2013;43(6):1165-9.
  • 20. Lippi G, Filippozzi L, Montagnana M, Salvagno GL, Franchini M, Guidi GC, et al.Clinical usefulness of measuring red blood cell distribution width on admission in patients with acute coronary syndromes. Clin Chem Lab Med. 2009;47(3):353-7
  • 21. Masoudkabir F, Karbalai S, Vasheghani-Farahani A, Aliabadi LL, Boroumand MA, Aiatollahzade-Esfahani F,et al.The association of liver transaminase activity with presence and severity of premature coronary artery disease. Angiology. 2011;62(8):614-18

Relationship Between Coronary Artery Disease Prevelance and RDW Levels

Year 2022, Volume: 17 Issue: 1, 107 - 114, 21.03.2022
https://doi.org/10.17517/ksutfd.847459

Abstract

Objective: The aim of this study is to investigate the relationship between the GENSINI score used to show the prevalence of atherosclerotic disease in patients with acute coronary syndrome (ACS) and the red blood cell distribution volume.
Material and Methods: 359 patients with a diagnosis of ACS who underwent coronary angiography were included in the study. The patients were divided into two groups as GENSINI score <20 and> 20, by analyzing their angiographic images. The demographic, clinical and laboratory parameters of these two groups were compared and the values predicting the GENISI score high were investigated.
Results: Of the 359 patients included in the study, 104 female patients were 255 men. While the number of patients with a GENSINI score of < 20 was 69, the number of patients with a GENSINI score of ≥20 was 290. It was observed that Red Cell Distribution Width (RDW) value was higher in the group with GENSINI score> 20 (13.7 ± 0.9 and 14.2 ± 1.4 p = 0.001). In the correlation analysis, a positive correlation was observed between RDW and GENSINI score (r: 0.137 p.009).RDW was seen to be the independent predictor of the GENSINI score. (OR: 1.417, 95% CI (1.037-1.935) p = 0.029)

Conclusion: RDW, which is an easy and accessible parameter in patients presenting with ACS, correlates with the severity of atherosclerotic heart disease and can be used as a predictor of atherosclerotic heart disease.

References

  • 1. Smith JN, Negrelli JM, Manek MB, Hawes EM, Viera AJ. Diagnosis and management of acute coronary syndrome: an evidence-based update. J Am Board Fam Med. 2015;28(2):283-93.
  • 2. Makki N, Brennan TM, Girotra S. Acute coronary syndrome. J Intensive Care Med. 2015;30(4):186-200.
  • 3. Hedayati T, Yadav N, Khanagavi J. Non-ST-Segment Acute Coronary Syndromes. Cardiol Clin. 2018;36(1):37-52.
  • 4. Piironen M, Ukkola O, Huikuri H, Havulinna AS, Koukkunen H, Mustonen J, et al. Trends in long-term prognosis after acute coronary syndrome. Eur J Prev Cardiol. 2017;24(3):274-80.
  • 5. Ndrepepa G, Kastrati A, Braun S, Mehilli J, Niemöller K, von Beckerath N, et al. N-terminal probrain natriuretic peptide and C-reactive protein in stable coronary heart disease. Am J Med 2006;119(4):355.e 1-8
  • 6. Evans TC, Jehle D. The red blood cell distribution width. J Emerg Med 1991;9(1):71-4.
  • 7. Kato H, Ishida J, Imagawa S, Saito T, Suzuki N, Matsuoka T,et al. Enhanced erythropoiesis mediated by activation of the reninangiotensi system via angiotensin II type 1a receptor. FASEB J 2005;19(14):2023-5.
  • 8. Biaggioni I, Robertson D, Krantz S, Jones M, Haile V.The anemia of primary autonomic failure and its reversal with recombinant erythropoietin. Ann Intern Med 1994;121(3):181-6.
  • 9. Melchio R, Rinaldi G, Testa E, Giraudo A, Serraino C, Bracco C, et al.Red cell distribution width predicts mid-term prognosis in patients hospitalized with acute heart failure: the RDW in Acute Heart Failure (RE-AHF) study. Intern Emerg Med. 2019;14(2):239-47.
  • 10. Dai DF, Hwang JJ, Lin JL, Lin JW, Hsu CN, Lin CM, et al. Joint effects of Nterminal pro-B-type-natriuretic peptide and Creactive protein vs angiographic severity in predicting major adverse cardiovascular events and clinical restenosis after coronary angioplasty in patients with stable coronary artery disease. Circ J 2008;72(8):1316-23.
  • 11. Patel KV, Ferrucci L, Ershler WB, Longo DL, Guralnik JM. Red blood cell distribution width and the risk of death in middle-aged and older adults. Arch Intern Med 2009;169(5):515-23.
  • 12. Perlstein TS, Weuve J, Pfeffer MA, Beckman JA. Red blood cell distribution width and mortality risk in a community-based prospective cohort. Arch Intern Med 2009;169(6):588-94.
  • 13. Pascual-Figal DA, Bonaque JC, Redondo B, Caro C, Manzano-Fernandez S, Sánchez-Mas J, et al.Red blood cell distribution width predicts long-term outcome regardless of anaemia status in acute heart failure patients. Eur J Heart Fail 2009;11(9):840-6.
  • 14. Förhécz Z, Gombos T, Borgulya G, Pozsonyi Z, Prohászka Z, Jánoskuti L. Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state. Am Heart J 2009;158(4):659-66.
  • 15. A-Marsh WL, Bishop JW, Darey TP. Evaluation of red cell volume distribution width (RDW). Haematol Pathol 1987;1:117–23.
  • 16. Tonelli M, Sacks F, Arnold M, Moye L, Davis B, Pfeffer M. Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation 2008;117:163–68.
  • 17. Cavusoglu E, Chopra V, Gupta A, Battala VR, Poludasu S, Eng C,et al. Relation between red blood cell distribution width (RDW) and all-cause mortality at two years in an unselected population referred for coronary angiography. Int J Cardiol. 2010 28;141(2):141-46
  • 18. Felker GM, Allen LA, Pocock SJ, Shaw LK, McMurray JJ, Pfeffer MA, et al.CHARM Investigators. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. J Am Coll Cardiol. 2007;50(1):40-7
  • 19. Warwick R, Mediratta N, Shaw M, McShane J, Pullan M, Chalmers J, et al.Red cell distribution width and coronary artery bypass surgery. Eur J Cardiothorac Surg. 2013;43(6):1165-9.
  • 20. Lippi G, Filippozzi L, Montagnana M, Salvagno GL, Franchini M, Guidi GC, et al.Clinical usefulness of measuring red blood cell distribution width on admission in patients with acute coronary syndromes. Clin Chem Lab Med. 2009;47(3):353-7
  • 21. Masoudkabir F, Karbalai S, Vasheghani-Farahani A, Aliabadi LL, Boroumand MA, Aiatollahzade-Esfahani F,et al.The association of liver transaminase activity with presence and severity of premature coronary artery disease. Angiology. 2011;62(8):614-18
There are 21 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Araştırma Makaleleri
Authors

Ufuk Özgül This is me 0000-0001-5044-5663

Hakan Güneş 0000-0003-3853-5046

Bayram Öztürk 0000-0001-7014-6484

Ahmet Yılmaz This is me 0000-0002-4267-384X

Publication Date March 21, 2022
Submission Date December 26, 2020
Acceptance Date March 31, 2021
Published in Issue Year 2022 Volume: 17 Issue: 1

Cite

AMA Özgül U, Güneş H, Öztürk B, Yılmaz A. Koroner Arter Hastalığı Yaygınlığı’nın RDW ile İlişkisi. KSU Medical Journal. March 2022;17(1):107-114. doi:10.17517/ksutfd.847459