Evaluation of Antibody Response to Biontech and Sinovac Vaccines Applied in Our Region

Yıl 2023, Cilt: 18 Sayı: 1, 115 - 119, 16.03.2023

Kaan Çeylan , Tekin Karslıgil , Feyza Nur Aşkın , Gülsüm Kaya Özen

https://doi.org/10.17517/ksutfd.1088761

Öz

Objective:The COVID-19 pandemic caused by SARS-CoV-2 has increased its impact since the day it started, infecting millions of people around the world and causing serious deaths.The fact that an effective and definitive treatment or prophylaxis method has not yet been found has increased the importance of vaccine studies.As of January 14, 2021, CoronaVac (Sinovac) and Pfizer-Biontech vaccines have been started to be administered to all citizens, starting from healthcare professionals in our country.
In this study, the efficacy of these two vaccines, which are actively applied in our country, was evaluated.
Method:Eighty-four volunteers who had not previously experienced COVID-19 by clinical, radiological or PCR method were included in the study.Serum samples were taken from the volunteers before the vaccine administration and 1 month after the first dose of vaccine administration.SARS-CoV-2 IgG levels were measured from the serum samples taken by ELISA method and examined in terms of the efficacy of two different vaccines.
Result:84 volunteers, including 39 women and 45 men, were included in the study; 50 volunteers preferred CoronaVac (Sinovac) and 34 volunteers preferred Pfizer-Biontech vaccine. Pre-vaccine SARS-CoV-2 IgG antibody titers of 13 volunteers administered CoronaVac (Sinovac) vaccine and 4 volunteers administered Pfizer-Biontech vaccine were positive.Of the volunteers whose pre-vaccination SARS-CoV-2 IgG antibody titers were negative; Seropositivity rate was 67.6% (25/37) in those who received a single dose of CoronaVac (Sinovac) vaccine, and 100% (30/30) in those who received a single dose of Pfizer-Biontech vaccine.
Conclusion: Pre-vaccine seropositivity was detected in 17 (20.2%) of the volunteers participating in the study. Of the volunteers who were seronegative before the study; 67.6% of those vaccinated with CoronaVac-Sinovac; Post-vaccine seropositivity developed in 100% of those vaccinated with Pfizer-Biontech. In the study, it is seen that the Pfizer-Biontech vaccine induces the immune system better after a single dose vaccination.

Anahtar Kelimeler

biontech, COVID-19, pandemic, sinovac

Bölgemizde Uygulanan Biontech ve Sinovac Aşılarına Karşı Gelişen Antikor Yanıtının Değerlendirilmesi

Öz

Amaç: SARS-CoV-2’nin yol açtığı COVİD-19 pandemisi başladığı günden bugüne etkisini arttırarak, dünya genelinde milyonlarca insanı enfekte etmiş ve ciddi oranda ölümlere yol açmıştır. Halen etkili ve kesin bir tedavi ya da profilaksi yönteminin bulunamamış olması aşı çalışmalarının önemini daha çok arttırmıştır. Ülkemizde 14 Ocak 2021 tarihi itibariyle başta sağlık çalışanları olmak üzere tüm vatandaşlara CoronaVac (Sinovac) ve Pfizer-Biontech aşıları uygulanmaya başlanmıştır.
Bu çalışmada ülkemizde aktif olarak uygulanan bu iki aşının etkinlikleri değerlendirilmiştir.
Yöntem: Çalışmaya daha önce klinik, radyolojik ya da PCR yöntemlerle COVİD-19 tanısı konulmamış olan 84 gönüllü dahil edilmiştir. Gönüllülerden aşı uygulamasından önce ve ilk doz aşı uygulamasının üzerinden 1 aylık bir süre geçtikten sonra serum örnekleri alınmıştır. Alınan serum örneklerinden, Enzim Linked Immun Sorbent Assay (ELISA) yöntemiyle SARS-CoV-2 IgG düzeyleri ölçülerek, iki farklı aşının etkinlikleri açısından incelenmiştir.
Bulgular: Çalışmaya 39’u kadın, 45’i erkek olmak üzere, 84 gönüllü dahil olmuş; 50 gönüllü CoronaVac (Sinovac), 34 gönüllü ise Pfizer-Biontech aşısını tercih etmişlerdir. CoronaVac (Sinovac) aşısı uygulanan 13, Pfizer-Biontech aşısı uygulanan 4 gönüllünün aşı öncesi SARS-CoV-2 IgG antikor titreleri pozitif olarak saptanmıştır. Aşı öncesi SARS-CoV-2 IgG antikor titreleri negatif olan gönüllülerden; tek doz CoronaVac (Sinovac) aşısı uygulananlarda %67,6 (25/37), tek doz Pfizer-Biontech aşısı uygulananlarda %100 (30/30) oranında seropozitiflik tespit edilmiştir.
Sonuç: Çalışmaya katılan gönüllülerin 17'sinde (%20,2) aşı öncesi seropozitiflik saptandı. Çalışma öncesi seronegatif olan gönüllülerden; CoronaVac-Sinovac ile aşılananların %67.6'sı; Pfizer-Biontech ile aşılananların %100'ünde aşı sonrası seropozitiflik gelişmiştir. Çalışmada Pfizer-Biontech aşısının tek doz aşılamadan sonra bağışıklık sistemini daha iyi uyardığı görülüyor.

Anahtar Kelimeler

biontech, COVİD-19, pandemi, sinovac

Kaynakça

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