Obesitiy: Its Complications and Available Medications

Abstract

Obesity is one of the common metabolic diseases which is tremendously on the rise. According to the World Health Organization (WHO), the number of patients has increased three times since 1975. A person with Body Mass Index (BMI) equal to or higher than 30.0 is considered obese. Previously considered only as a cosmetic concern, obesity has now been shown to be an aggravating element for various diseases and disorders including diabetes and cardiovascular diseases (CVD). The most common drugs subscribed by physicians include orlistat, rimonabant, liraglutide and sibutramine which have been proven to be effective to reduce body fat in patients. However, in the long run, patients have complained about symptoms which are mild like nausea, insomnia and dizziness to severe complications such as increase in risk of heart attack or stroke. The following review provides insights about synthetic drugs, their classification and their side-effects on human health. Furthermore, a gist of natural products i.e. phytochemicals that can be used as an alternative to these synthetic drugs has also been discussed in the review.

Keywords

• Obesity,Body Mass Index,Orlistat,Rimonabant,Phytochemicals,Sibutramine

Obezite: Komplikasyonları ve Tedavisinde Kullanılan İlaçlar

Abstract

Obezite olağanüstü düzeyde bir atış gösteren yaygın görülen metabolik hastalıklardan biridir. Dünya Sağlık Örgütü'ne (WHO) göre, hasta sayısı 1975'ten bu yana üç kat artmıştır. Beden kitle indeksi (BKİ) 30’a eşit veya 30’dan daha yüksek olan bir kişi obez olarak kabul edilmektedir. Daha önce sadece kozmetik bir sorun olarak kabul edilen obezitenin günümüzde diyabet ve kardiyovasküler hastalıklar (KVH) gibi çeşitli hastalıklar ve bozukluklar için ağırlaştırıcı bir unsur olduğu gösterilmiştir. Doktorlar tarafından en çok reçetelenen ilaçlar olan orlistat, rimonabant, liraglutid ve sibutraminin hastalarda vücut yağ oranını azaltmada etkili oldukları kanıtlanmıştır. Bununla birlikte, uzun vadede hastalar bulantı, uykusuzluk ve baş dönmesi gibi hafif semptomlardan ve kalp krizi veya inme gibi ciddi komplikasyonlardan şikayet etmektedir. Mevcut derleme sentetik ilaçlar, bu ilaçların sınıflandırılması ve insan sağlığı üzerindeki yan etkileri hakkında bilgi vermektedir. Ek olarak, bu sentetik ilaçlara alternatif olarak kullanılabilecek doğal ürünler olan fitokimyasalların bir özeti de mevcut derlemede tartışılmıştır.

Keywords

• Beden kitle indeksi,obezite,orlistat,sibutramin,fitokimyasallar,rimonabant

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