Investigation of Cardiovascular Risk Factors in Rosacea Patients

Abstract

Objective: Rosacea is a chronic, recurrent, inflammatory skin disease affecting the face. The role of chronic inflammation is known in the development of many diseases, especially cancer and cardiovascular diseases. This study aimed to investigate the risk of cardiovascular disease in rosacea patients.

Material and Methods: This study included 97 rosacea patients and 93 healthy volunteers. Patients in the rosacea and control groups were examined for demographics, medical history and the presence of associated cardiovascular disease risk factors. Laboratory investigations including fasting blood glucose, triglyceride, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and C-reactive protein levels were recorded in the rosacea and control groups.

Results: Body mass index, total cholesterol, low-density lipoprotein cholesterol, fasting blood glucose and C-reactive protein levels were higher in the patient group. Obesity, prediabetes, family history of premature cardivascular disease and high C-reactive protein levels in the patient group was significantly higher than the control group. There was no significant difference between patient and control groups in terms of age over 65 years old, hypertension, diabetes mellitus, dyslipidemia, smoking and alcohol consumption.

Conclusion: In this study, significant cardiovascular disease risk factors such as a family history of premature cardiovascular disease, obesity, prediabetes and high C-reactive protein levels were found to be higher in rosacea patients. Although the underlying mechanism is not clear, it is thought that chronic inflammation and disregulation of innate immune system increase risk of cardiovascular disease in rosacea patients.

Keywords

• Rosacea,cardiovascular disease,inflammation,immune system

ROZASE HASTALARINDA KARDİYOVASKÜLER HASTALIK RİSK FAKTÖRLERİNİN ARAŞTIRILMASI

Abstract

Amaç: Rozase yüzü etkileyen kronik, tekrarlayıcı, enflamatuvar bir deri hastalığıdır. Kronik enflamasyonun, kanser ve kardiyovasküler hastalıklar başta olmak üzere birçok hastalığın gelişimindeki rolü bilinmektedir. Bu çalışmada rozase hastalarında kardiyovasküler hastalık risk faktörlerinin araştırılması amaçlanmıştır.

Gereç ve Yöntemler: Çalışmaya 97 rozase hastası ve 93 sağlıklı gönüllü dahil edildi. Rozase ve kontrol grubundaki hastaların demografik özellikleri, özgeçmiş ve eşlik eden kardiyovasküler hastalık risk faktörlerinin varlığı öğrenildi. Ayrıca laboratuvar sonuçları incelenerek açlık kan şekeri, trigliserid, total kolesterol, yüksek dansiteli lipoprotein, düşük dansiteli lipoprotein ve C-reaktif protein düzeyleri kaydedildi.

Bulgular: Hasta grubunda vücut kitle indeksi, açlık kan şekeri, total kolesterol, düşük dansiteli lipoprotein ve C-reaktif protein düzeyleri kontrol grubuna göre yüksek bulundu. Ayrıca hasta grubunda obezite, prediyabet, ailede erken yaşta kardiyovasküler hastalık öyküsü ve yüksek C-reaktif protein düzeyi bulunan kişi sayısı kontrol grubuna göre yüksek bulundu. Hasta ve kontrol grupları arasında 65 yaş üstü, hipertansiyon, diyabetes mellitus, dislipidemi ve sigara gibi kardiyovasküler hastalık risk faktörleri ve alkol kullanan kişi sayısı açısından fark saptanmadı.

Sonuç: Bu çalışmada rozase hastalarında ailede erken yaşta kardiyovasküler hastalık öyküsü, obezite, prediyabet ve yüksek C-reaktif protein düzeyi gibi önemli kardiyovasküler hastalık risk faktörleri kontrol grubuna göre yüksek bulundu. Kronik enflamasyonun ve doğal bağışıklık yanıtındaki bozuklukların, rozase hastalarında kardiyovasküler hastalık riskini artırdığı düşünüldü.

Keywords

• Rozase,kardiyovasküler hastalıklar,enflamasyon,immün sistem

References

1. 1. Wilkin J, Dahl M, Detmar M, Drake L, Feinstein A, Odom R et al. Standard classification of rosacea: report of the national rosacea society expert committee on the classification and staging of rosacea. J Am Acad Dermatol. 2002;46(4):584-7.
2. 2. Chosidow O, Cribier B. Epidemiology of rosacea: updated data. Ann Dermatol Venereol. 2011;138(3):179-83.
3. 3. Spoendlin J, Karatas G, Furlano RI, Jick SS, Meier CR. Rosacea in patients with ulcerative colitis and crohn's disease: a population-based case-control study. Inflamm Bowel Dis. 2016;22(3):680-7.
4. 4. Belli AA, Gok SO, Akbaba G, Etgu F, Dogan G. The Relationship between rosacea and insulin resistance and metabolic syndrome. Eur J Dermatol. 2016;26(3):260-4.
5. 5. Duman N, Evans SE, Atakan N. Rosacea and cardiovascular risk factors: a case control study. J Eur Acad Dermatol Venereol. 2014;28(9):1165-9.
6. 6. Egeberg A, Hansen PR, Gislason GH, Thyssen JP. Exploring the association between rosacea and parkinson disease: a danish nationwide cohort study. JAMA Neurol. 2016;73(5):529-34.
7. 7. Mantovani A. Molecular pathways linking inflammation and cancer. Curr Mol Med. 2010;10(4):369-73.
8. 8. Libby P. Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol. 2012;32(9):2045-51.

9. 9. Mehta NN, Azfar RS, Shin DB, Neimann AL, Troxel AB, Gelfand JM. Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the general practice research database. Eur Heart J. 2010;31(8):1000-6.
10. 10. Szmitko PE, Wang C, Weisel RD, Almeida JR, Anderson TJ, Verma S. New markers of inflammation and endothelial cell activation. Circulation. 2003;108(16):1917-23.
11. 11. Egeberg A, Hansen PR, Gislason GH, Thyssen JP. Assessment of the risk of cardiovascular disease in patients with rosacea. J Am Acad Dermatol. 2016;75(2):336-9.
12. 12. Hua TC, Chung PI, Chen YJ, Wu LC, Chen YD, Hwang CY et al. Cardiovascular comorbidities in patients with rosacea: a nationwide case-control study from taiwan. J Am Acad Dermatol. 2015;73(2):249-54.
13. 13. Belli AA, Altun I. Assessment of framingham risk score and systemic coronary risk evaluation in rosacea patients. Dermatologica Sinica. 2017;35(3):127-30.
14. 14. Gotto AM. Role of c-reactive protein in coronary risk reduction: focus on primary prevention. Am J Cardiol. 2007;99(5):718-25.
15. 15. Buhl T, Sulk M, Nowak P, Buddenkotte J, McDonald I, Aubert J et al. Molecular and morphological characterization of inflammatory infiltrate in rosacea reveals activation of Th1/Th17 pathways. J Invest Dermatol. 2015;135(9):2198-208.
16. 16. Snekvik I, Smith CH, Nilsen TIL, Langan SM, Modalsli EH, Romundstad PR et al. Obesity, waist circumference, weight change and risk of incident psoriasis. J Invest Dermatol. 2017;137(12):2484-90.
17. 17. Murray ML, Bergstresser PR, Adams-Huet B, Cohen JB. Relationship of psoriasis severity to obesity using same-gender siblings as controls for obesity. Clin Exp Dermatol. 2009;34(2):140-4.
18. 18. Park HS, Park JY, Yu R. Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6. Diabetes Res Clin Pract. 2005;69(1):29-35.