Investigation of Cardiovascular Risk Factors in Rosacea Patients

Year 2019, , 226 - 232, 31.08.2019

Tuba Betül Karadeniz , Muhammed Karadeniz , Tijen Şahin Hatice Meral Ekşioğlu

https://doi.org/10.24938/kutfd.557734

Abstract

Objective: Rosacea is a chronic, recurrent,
inflammatory skin disease affecting the face. The role of chronic inflammation
is known in the development of many diseases, especially cancer and
cardiovascular diseases. This study aimed to investigate the risk of
cardiovascular disease in rosacea patients.

Material and Methods: This study included 97 rosacea
patients and 93 healthy volunteers. Patients in the rosacea and control groups
were examined for demographics, medical history and the presence of associated
cardiovascular disease risk factors. Laboratory investigations including
fasting blood glucose, triglyceride, total cholesterol, low-density lipoprotein
cholesterol, high-density lipoprotein cholesterol and C-reactive protein levels
were recorded in the rosacea and control groups.

Results: Body mass index, total cholesterol,
low-density lipoprotein cholesterol, fasting blood glucose and C-reactive
protein levels were higher in the patient group. Obesity, prediabetes, family
history of premature cardivascular disease and high C-reactive protein levels
in the patient group was significantly higher than the control group. There was
no significant difference between patient and control groups in terms of age
over 65 years old, hypertension, diabetes mellitus, dyslipidemia, smoking and
alcohol consumption.

Conclusion: In this study, significant cardiovascular
disease risk factors such as a family history of premature cardiovascular
disease, obesity, prediabetes and high C-reactive protein levels were found to
be higher in rosacea patients. Although the underlying mechanism is not clear,
it is thought that chronic inflammation and disregulation of innate immune
system increase risk of cardiovascular disease in rosacea patients.

Keywords

Rosacea, cardiovascular disease, inflammation, immune system

ROZASE HASTALARINDA KARDİYOVASKÜLER HASTALIK RİSK FAKTÖRLERİNİN ARAŞTIRILMASI

Abstract

Amaç: Rozase yüzü
etkileyen kronik, tekrarlayıcı, enflamatuvar bir deri hastalığıdır. Kronik
enflamasyonun, kanser ve kardiyovasküler hastalıklar başta olmak üzere birçok
hastalığın gelişimindeki rolü bilinmektedir. Bu çalışmada
rozase hastalarında kardiyovasküler hastalık risk faktörlerinin araştırılması
amaçlanmıştır.

Gereç ve
Yöntemler: Çalışmaya 97
rozase hastası ve 93 sağlıklı gönüllü dahil edildi. Rozase ve kontrol
grubundaki hastaların demografik özellikleri, özgeçmiş ve eşlik eden
kardiyovasküler hastalık risk faktörlerinin varlığı öğrenildi. Ayrıca
laboratuvar sonuçları incelenerek açlık kan şekeri, trigliserid, total
kolesterol, yüksek dansiteli lipoprotein, düşük dansiteli lipoprotein ve
C-reaktif protein düzeyleri kaydedildi.

Bulgular: Hasta grubunda vücut
kitle indeksi, açlık kan şekeri, total kolesterol, düşük dansiteli lipoprotein
ve C-reaktif protein düzeyleri kontrol grubuna göre yüksek bulundu. Ayrıca
hasta grubunda obezite, prediyabet, ailede erken yaşta kardiyovasküler hastalık
öyküsü ve yüksek C-reaktif protein düzeyi bulunan kişi sayısı kontrol grubuna
göre yüksek bulundu. Hasta ve kontrol grupları arasında 65 yaş üstü,
hipertansiyon, diyabetes mellitus, dislipidemi ve sigara gibi kardiyovasküler
hastalık risk faktörleri ve alkol kullanan kişi sayısı açısından fark saptanmadı.

Sonuç: Bu çalışmada rozase hastalarında ailede erken
yaşta kardiyovasküler hastalık öyküsü, obezite, prediyabet ve yüksek C-reaktif
protein düzeyi gibi önemli kardiyovasküler hastalık risk faktörleri kontrol
grubuna göre yüksek bulundu. Kronik enflamasyonun ve doğal bağışıklık
yanıtındaki bozuklukların, rozase hastalarında kardiyovasküler hastalık riskini
artırdığı düşünüldü.

Keywords

Rozase, kardiyovasküler hastalıklar, enflamasyon, immün sistem

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