Investigation of Cardiovascular Risk Factors in Rosacea Patients

Öz

Objective: Rosacea is a chronic, recurrent, inflammatory skin disease affecting the face. The role of chronic inflammation is known in the development of many diseases, especially cancer and cardiovascular diseases. This study aimed to investigate the risk of cardiovascular disease in rosacea patients.

Material and Methods: This study included 97 rosacea patients and 93 healthy volunteers. Patients in the rosacea and control groups were examined for demographics, medical history and the presence of associated cardiovascular disease risk factors. Laboratory investigations including fasting blood glucose, triglyceride, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and C-reactive protein levels were recorded in the rosacea and control groups.

Results: Body mass index, total cholesterol, low-density lipoprotein cholesterol, fasting blood glucose and C-reactive protein levels were higher in the patient group. Obesity, prediabetes, family history of premature cardivascular disease and high C-reactive protein levels in the patient group was significantly higher than the control group. There was no significant difference between patient and control groups in terms of age over 65 years old, hypertension, diabetes mellitus, dyslipidemia, smoking and alcohol consumption.

Conclusion: In this study, significant cardiovascular disease risk factors such as a family history of premature cardiovascular disease, obesity, prediabetes and high C-reactive protein levels were found to be higher in rosacea patients. Although the underlying mechanism is not clear, it is thought that chronic inflammation and disregulation of innate immune system increase risk of cardiovascular disease in rosacea patients.

Anahtar Kelimeler

• Rosacea,cardiovascular disease,inflammation,immune system

ROZASE HASTALARINDA KARDİYOVASKÜLER HASTALIK RİSK FAKTÖRLERİNİN ARAŞTIRILMASI

Öz

Amaç: Rozase yüzü etkileyen kronik, tekrarlayıcı, enflamatuvar bir deri hastalığıdır. Kronik enflamasyonun, kanser ve kardiyovasküler hastalıklar başta olmak üzere birçok hastalığın gelişimindeki rolü bilinmektedir. Bu çalışmada rozase hastalarında kardiyovasküler hastalık risk faktörlerinin araştırılması amaçlanmıştır.

Gereç ve Yöntemler: Çalışmaya 97 rozase hastası ve 93 sağlıklı gönüllü dahil edildi. Rozase ve kontrol grubundaki hastaların demografik özellikleri, özgeçmiş ve eşlik eden kardiyovasküler hastalık risk faktörlerinin varlığı öğrenildi. Ayrıca laboratuvar sonuçları incelenerek açlık kan şekeri, trigliserid, total kolesterol, yüksek dansiteli lipoprotein, düşük dansiteli lipoprotein ve C-reaktif protein düzeyleri kaydedildi.

Bulgular: Hasta grubunda vücut kitle indeksi, açlık kan şekeri, total kolesterol, düşük dansiteli lipoprotein ve C-reaktif protein düzeyleri kontrol grubuna göre yüksek bulundu. Ayrıca hasta grubunda obezite, prediyabet, ailede erken yaşta kardiyovasküler hastalık öyküsü ve yüksek C-reaktif protein düzeyi bulunan kişi sayısı kontrol grubuna göre yüksek bulundu. Hasta ve kontrol grupları arasında 65 yaş üstü, hipertansiyon, diyabetes mellitus, dislipidemi ve sigara gibi kardiyovasküler hastalık risk faktörleri ve alkol kullanan kişi sayısı açısından fark saptanmadı.

Sonuç: Bu çalışmada rozase hastalarında ailede erken yaşta kardiyovasküler hastalık öyküsü, obezite, prediyabet ve yüksek C-reaktif protein düzeyi gibi önemli kardiyovasküler hastalık risk faktörleri kontrol grubuna göre yüksek bulundu. Kronik enflamasyonun ve doğal bağışıklık yanıtındaki bozuklukların, rozase hastalarında kardiyovasküler hastalık riskini artırdığı düşünüldü.

Anahtar Kelimeler

• Rozase,kardiyovasküler hastalıklar,enflamasyon,immün sistem

Kaynakça

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