Incidence of Gallbladder Carcinoma in Our Cholecystectomy Patients

Abstract

Objective: We aimed to find the frequency of gallbladder carcinoma and the relationship between dysplasia and metaplasia, which are among predisposing factors for carcinoma.

Material and Methods: In this study, the histopathological results of 815 patients who underwent cholecystectomy between 2016-2019 in Ahi Evran Training and Research Hospital, Department of General Surgery were retrospectively analyzed.

Results: Of the patients who underwent cholecystectomy, 591 (72.5%) were female and 224 (27.5%) were male. The average age was 50.5 years for women and 54.1 years for men. The general average age was 51.5 years. Cholecystectomy was performed laparoscopically in 698 (85.6%) patients while in 117 (14.4%) patients the operation was either started as open cholecystectomy or the decision to convert to open cholecystectomy was made later during the operation for different reasons. Gallbladder carcinoma was detected in two (0.24%) patients, one 62-year-old male and one 67-year-old female. The rate of gallbladder carcinoma was 0.4%for male patients and 0.1%for female patients. Metaplasia in the gallbladder was detected in 16 (1.96%) patients, 15 of which were female and one was male. The average age of these patients was 43.6 years. Dysplasia was detected in only a 48-year-old male patient (0.12%).

Conclusion: Chronic irritation caused by the presence of gallstones leads to metaplasia which is a precancerous lesion. Therefore, we think that patients with gallstones should be evaluated for surgery or close follow-up, even if they do not have symptoms.

Keywords

• acute cholecystitis
• intestinal metaplasia
• Gall bladder
• gallbladder cancer

Project Number

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KOLESİSTEKTOMİ YAPILAN HASTALARIMIZDA SAFRA KESESİ KARSİNOMU İNSİDANSI

Abstract

Amaç: Çalışmamızda kliniğimizde yapılan kolesistektomileri retrospektif olarak tarayarak safra kesesi karsinomu sıklığını ve karsinom predispozan faktörleri arasında yer alan displazi ve metaplazi arasındaki ilişkiyi bulmayı amaçladık.

Gereç ve Yöntemler: Bu çalışmada Ahi Evran Eğitim ve Araştırma Hastanesi Genel Cerrahi Anabilim Dalında 2016-2019 yılları arasında kolesistektomi ameliyatı yapılan 815 hastanın histopatolojik sonuçları retrospektif olarak incelenmiştir.

Bulgular: Kolesistektomi yapılan hastaların 591’i (%72.5) kadın 224’ü (%27.5) erkekti. Yaş ortalaması kadınlarda 50.5 yıl, erkeklerde 54.1 yıl olarak bulundu. Genel yaş ortalaması 51.5 yıl idi. Kolesistektomi ameliyatı 698 (%85.6) hastaya laparoskopik olarak yapılmış, 117 (%14.4) hastada ise ya açık olarak başlanmış ya da sonradan farklı sebeplerle açık kolesistektomiye geçilmişti. Biri 62 yaşında erkek, diğeri 67 yaşında kadın olmak üzere iki (%0.24) hastada safra kesesi karsinomu saptandı. Erkek ve kadın cinsiyete göre safra kesesi karsinomu oranı sırasıyla %0.4 ve %.0.1 idi. Safra kesesinde metaplazi 16 (%1.96) hastada saptandı. Hastaların 15 tanesi kadın, bir tanesi erkekti. Bu hastaların yaş ortalaması 43.6 yıl idi. Sadece 48 yaşında bir erkek hastada displazi saptandı (%0.12).

Sonuç: Safra taşı varlığının neden olduğu kronik irritasyon, prekanseröz bir lezyon olan metaplaziye yol açmaktadır. Bu nedenle safra taşı olan hastaların semptomları olmasa dahi ameliyat için değerlendirilmesinin ya da yakın takibinin uygun olacağını düşünmekteyiz.

Keywords

• safra kesesi
• akut kolesistit
• intestinal metaplazi
• safra kesesi kanseri

Supporting Institution

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Project Number

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Thanks

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