Endocrine Disruptors: Effect of Bisphenol-A on Human Health

Abstract

Endocrine disruptors are naturally occurring or man-made substances that at certain doses can mimic or interfere with the endocrine systems. Bisphenol-A is an endocrine disruptor due to its estrogenic properties and effects on the estrogen receptor. We are exposed to Bisphenol-A, which is especially used in the plastics industry, in our daily lives without even being aware of it. The effects of Bisphenol-A on human health have been on the agenda recently, and worrying negative effects have been discovered. As in many countries, even if there is a restriction on its use in our country, this is not considered possible in practice. In this review, it is aimed to draw attention to the negative effects of Bisphenol-A on human health such as endocrine system insulin resistance, obesity, polycystic ovary syndrome, cardiovascular diseases, breast cancer, abortion and premature birth.

Keywords

• Endocrine disruptors
• bisphenol A
• human health

ENDOKRİN BOZUCULAR: BİSFONEL-A’NIN SAĞLIK ÜZERİNE ETKİLERİ

Abstract

Endokrin bozucular, belirli dozlarda endokrin sistemlerini taklit edebilen veya bunlara müdahale edebilen, doğal olarak meydana gelen veya suni maddelerdir. Östrojenik özelliği ve östrojen reseptörü üzerinden etki etmesi nedeniyle, bir endokrin bozucu kimyasal olan özellikle plastik sanayinde kullanılan Bisfenol-A’ya günlük yaşantımızda farkında bile olmadan maruz kalmaktayız. Bisfenol-A’nın insan sağlığı üzerindeki etkileri son günlerde gündemde olup kaygı verici düzeyde olumsuz etkiler keşfedilmiştir. Birçok ülkede olduğu gibi ülkemizde de kullanımına sınırlama getirilse bile bu pratikte pek de mümkün görülmemektedir. Bu derlemede Bisfenol-A’nın özellikle endokrin sistem insülin direnci, obezite, polikistik over sendromu, kardiyovasküler hastalıklar, meme kanseri, abortus ve erken doğum gibi insan sağlığı üzerindeki olumsuz etkileri üzerine dikkat çekmek amaçlanmıştır.

Keywords

• endokrin bozucular
• Bisfenol A
• insan sağlığı

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