Ratlarda Oral veya Topikal Olarak Uygulanan Borun Yara İyileşmesi ve Oksidatif Stres Üzerine Etkilerinin Karşılaştırılması

Year 2020, , 11 - 18, 31.03.2020

Meral Konca Musa Korkmaz

https://doi.org/10.30607/kvj.646939

Cited By: 5

Abstract

Bu çalışmanın amacı, borun yara iyileşmesi ve bazı
antioksidan ve oksidan parametreler üzerine olan etkisinin belirlenmesidir.
Çalışmada,  toplam 32 adet erişkin erkek
Wistar ratı, kontrol grubu, lokal bor (LB) grubu, oral bor (OB) grubu ve
oral+lokal bor (OLB) grubu olmak üzere 
ratgele dört gruba ayrıldı.  Genel
anestezi altında,  ratların sırt
bölgesinde 1,5 cm çapında dairesel tam kat bir deri defekti oluşturuldu. OB
grubunda bulunan ratlara oral olarak 10 mg/kg bor, LB grubunda bulunan ratlara
topikal % 3’lük borik asit,  OLB grubunda
bulunan ratlara oral 10 mg/kg bor ile birlikte topikal olarak % 3’lük borik
asit uygulandı. Kontrol grubuna ise herhangi bir ilaç uygulanmadı.
Histopatalojik inceleme için yara dokusu örnekleri alındı.  Histopatolojik olarak; repitelizasyon,
granulasyon dokusu oluşumu, kollagen formasyonu, yangısal hücre oluşumu ve
neovaskülarizasyonun LB ve OLB gruplarında kontrol ve OB grubuna göre daha iyi
olduğu belirlendi. OB ve OLB gruplarında kan ve yara dokusu MDA düzeylerinin
kontrol ve LB grubuna göre düşük olduğu belirlendi (p<0,05). Sonuç olarak; yara sağaltımında, lokal olarak borik asit
kullanıma ek olarak antioksidan özelliklerinden dolayı oral bor kullanımının
yara iyileşmesine katkı sağladığı söylenebilir

Keywords

Antioksidan, bor, malondialdehit, rat, yara iyileşmesi

Supporting Institution

Afyon Kocatepe Üniversitesi, Bilimsel Araştırma Projeleri Koordinasyon Birimi

Project Number

16.SAG.BIL.25

Comparison of Effects of Administration of Oral or Topical Boron on Wound Healing and Oxidative Stress in Rats

Abstract

The purpose of this study was to determine the effects
of boron on wound healing and further evaluate some antioxidant and oxidant
characteristics. A total of 32 adult male Wistar rats were divided into four
groups; control group, local boron (LB) group, oral boron (OB) group, and
oral+local boron (OLB) group. Under general anesthesia, a circular
full-thickness skin defect with a diameter of 1.5 cm was created on the dorsal
region of the rats. Boron (10 mg/kg) was administered per oral in OB group and
3% boric acid was administered topically in LB group, and 10 mg/kg boron was
administered per oral and 3% boric acid was applied topically in OLB group.
Control group did not receive any medication. In histopathological examination,
re-epithelialization, granulation tissue formation, collagen formation,
inflammatory cell formation, and neovascularization were found to be more superior
in LB and OLB groups as compared to the control and OB groups. Blood and wound
tissue MDA levels in OB and OLB groups were lower with respect to the control
and LB groups (p<0.05). In conclusion, oral administration of boron in
addition to topical treatment contributes the wound healing due to the
antioxidant property of boron in wound healing
process.

Keywords

Antioxidant, boron, malondialdehyde, rat, wound healing

Project Number

16.SAG.BIL.25

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