Used as a Probiotic Lactobacillus spp. Strains of Cholesterol Lowering Effects and Possible Mechanisms

Abstract

High cholesterol levels are one of the most important risk factors for coronary heart disease, although cholesterol is a major building block for all body tissues. Therefore, reduction of serum cholesterol is, very important to prevent cardiovascular disease. Current lifestyle, dietary measures and pharmaceutical agents are inadequate for regulating cholesterol levels. In recent years, there have been new approaches to lowering levels of high cholesterol. Among these applications, the use of probiotic bacteria is also important. To date, many in vitro and in vivo studies have been conducted on this subject and it has been shown that probiotic products, especially those containing certain Lactobacillus species, reduce the levels of high cholesterol levels in the blood. Probiotic bacteria have demonstrated potential to lower cholesterol levels by different mechanisms, as bile salt hydrolase activity, production of compounds that inhibit enzymes such as 3-hydroxy-3-methylglutaryl coenzyme A, and cholesterol assimilation.

Keywords

• Lactic Acid Bacteria,Lactobacillus spp.,Cholesterol,Probiotics

Probiyotik Olarak Kullanılan Lactobacillus spp. Suşlarının Kolesterol Düşürücü Etkileri ve Olası Mekanizmalar

Abstract

Kolesterol tüm vücut dokuları için temel bir yapı taşı olduğu halde, kandaki kolesterol seviyesinin yüksek olması, koroner kalp hastalığının en önemli risk faktörlerinden biridir. Bu sebeple, serum kolesterol seviyelerinin düşürülmesi, özellikle kalp-damar hastalıklarının önlenmesi bakımından büyük önem taşımaktadır. Mevcut yaşam tarzı, diet ile alınan önlemler ve farmasötik maddeler kolesterol seviyesinin düzenlenmesinde yetersiz kalmaktadır. Son yıllarda, kandaki yüksek kolesterol seviyelerinin düşürülmesinde yeni yaklaşımlar söz konusudur. Bu uygulamalar arasında, probiyotik bakterilerin kullanımı önemlidir. Bugüne kadar bu konu üzerinde birçok in vitro ve in vivo çalışma yapılmış ve özellikle belirli Lactobacillus türlerini içeren probiyotik ürünlerin kandaki yüksek kolesterol seviyelerini azalttığı gösterilmiştir.  Probiyotik bakterilerin, safra tuzu hidrolizi aktivitesi, 3-hidroksi-3-metilglutaril, koenzim A gibi inhibe edici enzimler üretmeleri ile kolesterol asimilasyonu gibi farklı mekanizmalar kolesterol seviyesini düşürme potansiyeline sahip olduklarını göstermektedir.

Keywords

• Laktik Asit Bakterileri,Lactobacillus spp.,Kolesterol,Probiyotikler

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