Abstract
AbstractScavenger Receptors and its Association with Hepatitis C The main tasks of scavenger receptors playing an important role in innate and adaptive immunity are to recognize the modified biomolecules and then, mediate their destruction and removal from the body. Scavenger receptors which are divided into eight different classes (A–H) play a significant role in the pathogenesis of many diseases. Hepatitis C, affecting the liver, is a severe infection diseases causing chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. In recent years, it has been indicated that some scavenger receptors take an important part in the pathogenesis of hepatitis C virus, and hence, might be a potential target for new anti-viral drugs. In this review, significant features of scavenger receptors and the relation of some of these receptors to the hepatitis C virus were discussed.
References
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- Kurban S, Mehmetoğlu l. Okside düşük dansiteli lipoprotein otoantikorları ve klinik önemi. Türkiye Klinikleri JMed Sci 2005;25(1):73-84.
- Hiraoka A, Horiike N, Akbar SM, Michitaka K, Matsuyama T, Onji M. Soluble CDl63 in patients with liver diseases: very high levels of soluble CDl63 in patients with fulminant hepatic failure. J Gastroenterol ;40(1):52-6. Meredith LW, Wilson GK, Fletcher NF, McKeating JA. Hepatitis C virus entry: beyond receptors. Institute for Biomedical Research, University of Birmingham, Birmingham, UK. Rev Med Viral 2012;22(3):182-93.
- Plüddemann A, Neyen C, Gordon S. Macrophage scavenger receptors and host-derived ligands. Methods ;43(3):207-17. WHO: Hepatitis C. Erişim adresi: http://Www.who.int/ mediacentre/factsheets/fs164/en/index.html. Erişim tarihi: 01.05.2013.
- Goldstein JL, Ho YK, Basu SK, Brown MS. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc Natl Acad Sci 1979;76(1): 7.
- Nobelprize. Erişim adresizhttp://Www.nobelprize.org/ nobel_prizes/medicine/laureates/1985/Erişim tarihi: 05.2013.
- Kodama T, Freeman M, Rohrer L, Zabrecky J, Matsudaira P, Krieger M. Type I macrophage scavenger receptor contains a-helical and collagen-like coiled coils. Nature ;343(6258):531-5.
- Endemann G, Stanton LW, Madden KS, Bryant CM, White RT, ProtterAA. CD3 6 is a receptor for oxidized low density lipoprotein. JBiol Chem 1993;268(16):11811-6. ll. Sawamura T, Kume N, Aoyama T, Moriwaki H,
- Hoshikawa H, Aiba Y, Tanaka T, Miwa S, Katsura Y, Kita Greaves DR, Gordon S. The macrophage scavenger receptor at 30 years of age: current knowledge and future Plüddemann A, Mukhopadhyay S, Gordon S. The interaction of macrophage receptors with bacterial ligands. Expert Rev Mol Med 2006;8(28):1-25.
- Wong-Staal F, Syder AJ, McKelvy JF. Targeting HCV entry for development of therapeutics. Viruses Zeisel MB, Fofana I, FaŞ-Kremer S, Baumert TF. Hepatitis C virus entry into hepatocytes: molecular Pavio N, Lai MM. The hepatitis C virus persistence: how to evade the immune system? J Biosci 2003;28(3):287
- Zahid MN, Turek M, Xiao F, Thi VL, Gue'rin M, Fofana I, Bachellier P, Thompson J, Delang L, Neyts J, Bankwitz D, Pietschmann T, Dreux M, Cosset FL, Grunert F,Baumert TF, Zeisel MB. The postbinding activity of scavenger receptor class B type I mediates initiation of hepatitis C Virus infection and viral dissemination. Hepatology 2013;57(2):492-504.
- Benedicto I, Molina-Jimenez F, Garcia-Buey L, Gondar V, Lopez-Cabrera M, Moreno-Otero R, Pedro L. Maj ano. Role of tight junctions in hepatitis C virus infection. Rev Esp Enferm Dig 2012;104(5):255-63.
Abstract
Türkçe Özet: Doğal ve kazanılmış bağışıklıkta önemli rolü olan çöpçü reseptörlerin temel görevi modifiye biyomolekülleri tanımak ve bunların vücuttan uzaklaştırılmasına ve yıkılmasına aracılık etmektir. Sekiz farklı sınıfa (A-H) ayrılan çöpçü reseptörler pek çok hastalığın patogenezinde rol oynamaktadırlar. Hepatit C karaciğeri etkileyen kronik hepatit, karaciğer sirozu ve hepatosellüler karsinomaya neden olan ciddi bir enfeksiyon hastalığıdır. Son yıllarda hepatit C virüsünün patogenezinde bazı çöpçü reseptörlerin önemli rol oynadığı ve yeni anti-viral ilaçlar için hedef oluşturabileceği belirtilmektedir. Bu derlemede çöpçü reseptörlerin özellikleri ve bazı çöpçü reseptörler ile hepatit C virüsünün ilişkisi irdelenmiştir.
References
- Çetinkaya A, Yılmaz E. Çöpçü reseptörler: özellikleri ve hastalık ilişkileri. Hacettepe Tıp Dergisi 2009; 40 (3): 145
- Kurban S, Mehmetoğlu l. Okside düşük dansiteli lipoprotein otoantikorları ve klinik önemi. Türkiye Klinikleri JMed Sci 2005;25(1):73-84.
- Hiraoka A, Horiike N, Akbar SM, Michitaka K, Matsuyama T, Onji M. Soluble CDl63 in patients with liver diseases: very high levels of soluble CDl63 in patients with fulminant hepatic failure. J Gastroenterol ;40(1):52-6. Meredith LW, Wilson GK, Fletcher NF, McKeating JA. Hepatitis C virus entry: beyond receptors. Institute for Biomedical Research, University of Birmingham, Birmingham, UK. Rev Med Viral 2012;22(3):182-93.
- Plüddemann A, Neyen C, Gordon S. Macrophage scavenger receptors and host-derived ligands. Methods ;43(3):207-17. WHO: Hepatitis C. Erişim adresi: http://Www.who.int/ mediacentre/factsheets/fs164/en/index.html. Erişim tarihi: 01.05.2013.
- Goldstein JL, Ho YK, Basu SK, Brown MS. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc Natl Acad Sci 1979;76(1): 7.
- Nobelprize. Erişim adresizhttp://Www.nobelprize.org/ nobel_prizes/medicine/laureates/1985/Erişim tarihi: 05.2013.
- Kodama T, Freeman M, Rohrer L, Zabrecky J, Matsudaira P, Krieger M. Type I macrophage scavenger receptor contains a-helical and collagen-like coiled coils. Nature ;343(6258):531-5.
- Endemann G, Stanton LW, Madden KS, Bryant CM, White RT, ProtterAA. CD3 6 is a receptor for oxidized low density lipoprotein. JBiol Chem 1993;268(16):11811-6. ll. Sawamura T, Kume N, Aoyama T, Moriwaki H,
- Hoshikawa H, Aiba Y, Tanaka T, Miwa S, Katsura Y, Kita Greaves DR, Gordon S. The macrophage scavenger receptor at 30 years of age: current knowledge and future Plüddemann A, Mukhopadhyay S, Gordon S. The interaction of macrophage receptors with bacterial ligands. Expert Rev Mol Med 2006;8(28):1-25.
- Wong-Staal F, Syder AJ, McKelvy JF. Targeting HCV entry for development of therapeutics. Viruses Zeisel MB, Fofana I, FaŞ-Kremer S, Baumert TF. Hepatitis C virus entry into hepatocytes: molecular Pavio N, Lai MM. The hepatitis C virus persistence: how to evade the immune system? J Biosci 2003;28(3):287
- Zahid MN, Turek M, Xiao F, Thi VL, Gue'rin M, Fofana I, Bachellier P, Thompson J, Delang L, Neyts J, Bankwitz D, Pietschmann T, Dreux M, Cosset FL, Grunert F,Baumert TF, Zeisel MB. The postbinding activity of scavenger receptor class B type I mediates initiation of hepatitis C Virus infection and viral dissemination. Hepatology 2013;57(2):492-504.
- Benedicto I, Molina-Jimenez F, Garcia-Buey L, Gondar V, Lopez-Cabrera M, Moreno-Otero R, Pedro L. Maj ano. Role of tight junctions in hepatitis C virus infection. Rev Esp Enferm Dig 2012;104(5):255-63.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | September 1, 2012 |
| Submission Date | June 13, 2014 |
| Published in Issue | Year 2012 Volume: 5 Issue: 3 |
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MEU Journal of Health Sciences Assoc was began to the publishing process in 2008 under the supervision of Assoc. Prof. Gönül Aslan, Editor-in-Chief, and affiliated to Mersin University Institute of Health Sciences. In March 2015, Prof. Dr. Caferi Tayyar Şaşmaz undertook the Editor-in Chief position and since then he has been in charge.
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