Çöpçü Reseptörler ve Hepatit C ile İlişkisi

Yıl 2012, Cilt: 5 Sayı: 3, 9 - 17, 01.09.2012

Gülay Börekçi Duygu Yolal Nurcan Aras

Öz

AbstractScavenger Receptors and its Association with Hepatitis C The main tasks of scavenger receptors playing an important role in innate and adaptive immunity are to recognize the modified biomolecules and then, mediate their destruction and removal from the body. Scavenger receptors which are divided into eight different classes (A–H) play a significant role in the pathogenesis of many diseases. Hepatitis C, affecting the liver, is a severe infection diseases causing chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. In recent years, it has been indicated that some scavenger receptors take an important part in the pathogenesis of hepatitis C virus, and hence, might be a potential target for new anti-viral drugs. In this review, significant features of scavenger receptors and the relation of some of these receptors to the hepatitis C virus were discussed.

Anahtar Kelimeler

scavenger receptors; hepatitis C virus; pathogenesis; antiviral drug

Çöpçü Reseptörler ve Hepatit C ile İlişkisi

Öz

Türkçe Özet: Doğal ve kazanılmış bağışıklıkta önemli rolü olan çöpçü reseptörlerin temel görevi modifiye biyomolekülleri tanımak ve bunların vücuttan uzaklaştırılmasına ve yıkılmasına aracılık etmektir. Sekiz farklı sınıfa (A-H) ayrılan çöpçü reseptörler pek çok hastalığın patogenezinde rol oynamaktadırlar. Hepatit C karaciğeri etkileyen kronik hepatit, karaciğer sirozu ve hepatosellüler karsinomaya neden olan ciddi bir enfeksiyon hastalığıdır. Son yıllarda hepatit C virüsünün patogenezinde bazı çöpçü reseptörlerin önemli rol oynadığı ve yeni anti-viral ilaçlar için hedef oluşturabileceği belirtilmektedir. Bu derlemede çöpçü reseptörlerin özellikleri ve bazı çöpçü reseptörler ile hepatit C virüsünün ilişkisi irdelenmiştir.

Anahtar Kelimeler

çöpçü reseptör; hepatit C virüsü; patogenez; antiviral ilaç

Kaynakça

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