Oral liken planus ile 25(OH) D vitamini arasindaki ilişki

Year 2022, Volume: 15 Issue: 1, 24 - 28, 30.04.2022

Belma Türsen Erdinç Terzi

https://doi.org/10.26559/mersinsbd.1005541

Abstract

Amaç: Oral liken planus hastalarında serum 25(OH) Vitamin D seviyelerini incelemek ve sağlıklı bireylerden oluşan kontrol grubu ile karşılaştırarak serum 25(OH) Vitamin D seviyeleri ile oral liken planus arasında olası bir ilişki olup olmadığını belirlemektir. Yöntem: Ekim 2017- Mart 2018 tarihleri arasında oral liken planus tanısı konulan 25 hasta ve 83 sağlıklı birey çalışmaya alındı. Her iki grubun serum D vitamini seviyeleri yüksek performans likit kromatografi yöntemi ile değerlendirildi. Ayrıca serum paratiroid hormon, kalsiyum, fosfor, alkalen fosfataz seviyeleri de incelendi. Bulgular: Çalışmamıza 12- 53 yaş (ort 27.56 ± 6.8) arasındaki 25 hasta ve kontrol grubunda 18- 58 yaş arası (ort 34.38 ± 7.3) 83 sağlıklı birey katılmıştır. Oral liken planuslu hastalarda serum 25(OH) Vitamin D seviyeleri ortalama 21.23 ng / ml (7.34- 60.8 ng / ml) olarak belirlendi. Kontrol grubunda ise serum 25(OH) Vitamin D seviyeleri ortalama 23.4 ng / ml (3- 69.2 ng / ml) olarak belirlendi. Her iki grup arasında serum D vitamini düzeyleri arasında istatistiksel olarak anlamlı bir fark yoktu(p> 0.05 ). Sonuç: Bu sonuçlara göre serum 25(OH) D vitamini ile oral liken planus arasında herhangi bir ilişki bulunmamıştır.

Keywords

oral liken planus, D vitamini, Serum

Association between oral licken planus and 25(OH) vitamin D

Abstract

Aim: To evaluate serum 25-hydroxyvitamin D (25 (OH) D) levels in oral lichen planus patients and to determine whether there is a possible relationship between serum 25 (OH) D levels and oral lichen planus by comparing it with a control group of healthy individuals. Methods: 25 patients with oral lichen planus and 83 healthy individuals diagnosed between October 2017 and March 2018 were included in the study. Serum vitamin D levels of the study group were evaluated by high performance liquid chromatography method. Serum parathyroid hormone calcium, phosphorus, alkaline phosphatase levels were also examined. Results: 25 patients between 12- 53 years old(mean 27.56± 6.8) and 83 healthy individuals between 18-58 years old(mean: 34.38 ± 7.3) in the control group participated in our study. Serum 25 (OH) D levels were determined as an average of 21.23 ng / ml (7.34- 60.8 ng / ml) in patients with oral lichen planus. In the control group, serum 25 (OH) D levels were determined to be 23.4 ng / ml (3-69.2 ng / ml). There was no statistically significant difference between the serum vitamin D levels between the two groups(p> 0.05 ). Conclusion: According to these results, no relationship was found between oral lichen planus and serum 25 (OH) vitamin D.

Keywords

Oral lichen planus, 25(OH) vitamin D, serum

References

• 1. Alrashdan MS, Cirillo N, McCullough M.Oral lichen planus: a literature review and update. Arch Dermatol Res. 2016; 308(8): 539-51.doi:10.1007/s00403-016-1667-2.
• 2. Olson MA, Rogers RS 3rd, Bruce AJ. Oral lichen planus.Clin Dermatol.2016;34(4):495-504.doi:10.1016/j.clindermatol.2016.02.023.
• 3. Kurago ZB.Etiology and pathogenesis of oral lichen planus: an overview.Oral Surg Oral Med Oral Pathol Oral Radiol 2016; 122: 72-80.doi:10.1016/j.oooo.2016.03.011.
• 4. Mausker M.Erosive lichen planus.Obstet Gynecol Clin North Am. 2017; 44: 407-20.doi:10.1016/j.ogc.2017.04.004.
• 5. Kusari A,Ahluwalia J.Lichen planus.New Engl J Med. 2018; 379: 567. doi:10.1056/NEJMicm1802078.
• 6. Olson MA, Rogers RS 3rd, Bruce AJ.Oral lichen planus.Clin Dermatol. 2016; 34: 495-504.doi:10.1016/j.clindermatol.1026.02.023.
• 7. Mattner F, Smiroldo S, Galbiati F, et al. Inhibition of Th1 development and treatment of chronic-relapsing experimentalallergic encephalomyelitis by a non-hypercalcemic analogue of 1,25-dihydroxyvitamin D3.Eur J Immunol. 2000; 30: 498–508.doi:10.1002/1521-4141(200002)30:2.
• 8. Cippitelli M, Santoni A. Vitamin D3: a transcriptional modulator of the interferon-gamma gene.Eur J Immunol. 1998; 28: 3017–30.doi:10.1002/(SICI)1521-4141(199810)28:10.
• 9. Holick MF. Vitamin D Deficiency.New England Journal of Medicine. 2007; 357: 266–81.doi:10.1056/NEJMra070553.
• 10. D'Aurizio F, Villalta D, Metus P, Doretto P, Tozzoli R. Is vitamin D a player or not in the pathophysiology of autoimmune thyroid diseases?Autoimmun Rev. 2015;14: 363–9. doi:10.1016/j.autrev.2014.10.008.
• 11. Kriegel MA, Manson JE, Costenbader KH. Does vitamin D affect risk of developing autoimmune disease? A systematic review.Semin Arthritis Rheum. 2011; 40: 512–31.doi:10.1016/j.semiartrit.2010.07.009.
• 12. Gupta A, Mohan MPS, Kamarthi N,et al. Serum Vitamin D Level in Oral Lichen Planus Patients of North India- A Case-Control Study. J of Dermatol Res Ther. 2017; 1(3): 1-16.doi:10.14302/issn.2471-2175.jdrt-17-1481 .
• 13. Du J, Li R, Yu F. Experimental study on 1,25(OH) 2 D 3 amelioration of oral lichen planus through regulating NF-κB signaling pathway. Oral Dis. 2017; 23: 770-8.doi:10.1111/odi.12659.
• 14.Bahramian A,Bahramian M,Mehdipour M,et al. Comparing Vitamin D Serum Levels in Patients with Oral Lichen Planus and Healthy Subjects. J Dent (Shiraz). 2018; 19(3): 212-6.
• 15. Varma RB, Valappila NJ, Pai A, Saddu SC, Mathew N. Oral Lichen Planus: Is Vitamin D Deficiency a Predisposing Factor? A Case Report. Int J Sci Stud. 2014; 2: 230–2.
• 16. Hekimsoy Z, Dinç G, Kafesçiler S, et al. Vitamin D status among adults in the Aegean region of Turkey.BMC Public Health. 2010; 10: 782.doi:10.1186/1471-2458-10-782.
• 17. Orun E, Sezer S, Kanburoglu MK, et al. Vitamin D deficiency in healthy children and adolescent.Clin Invest Med. 2015; 38: E261–266.
• 18. Van der Meer IM, Middelkoop BJ, Boeke AJ, Lips P. Prevalence of vitamin D deficiency among Turkish, Moroccan, Indian and Sub-Sahara African populations in Europe and their countries of origin: overview.Osteoporos Int. 2011; 22: 1009–1021.doi:10.1007/s00198-010-1279-1.
• 19. Gannagé-Yared MH, Chemali R, Yaacoub N, et al. Hypovitaminosis D in a sunny country: relation to lifestyle and bone markers.J Bone Miner Res. 2000; 15: 1856– 1862.doi:10.1359/jbmr.2000.15.09.1856.
• 20. Mishal AA. Effects of different dress styles on vitamin D levels in healthy young Jordanian women.Osteoporos Int. 2001; 12: 931–935.doi:10.1007/s001980170021.
• 21. Lips P. Vitamin D status and nutrition in Europe and Asia. J Steroid Biochem Mol Biol. 2007;103:620–625.doi:10.1016/j.jsbmb.2006.12.076.