Covid 19 pandemisinin erken döneminde SARS-CoV-2 ile enfekte çocukların epidemiyolojik, klinik ve laboratuvar özelliklerinin değerlendirilmesi

Year 2022, Volume: 15 Issue: (Özel Sayı-1) 21. Mersin Pediatri Günleri Bildiri Kitabı, 157 - 169, 30.06.2022

Berfin Özgökçe Özmen Mehtap Akça Gülçin Bozlu Merve Türkegün Necdet Kuyucu

Abstract

Amaç: Bu çalışmada, COVID-19 pandemisinin erken döneminde SARS-CoV-2 ile enfekte çocukların demografik, epidemiyolojik, klinik ve laboratuvar özelliklerini değerlendirmeyi, klinik bulguların yaşa göre değişkenlik gösterip göstermediğini belirlemeyi amaçladık. Yöntem: Hastanemiz Çocuk Enfeksiyon Hastalıkları COVID-19 polikliniği ve Çocuk Acil polikliniğine başvuran olguların vaka kayıt formları ile retrospektif olarak tarandı. 16 Mart 2020 ile 31 Ocak 2020 tarihleri arasında 0-18 yaşları arasında doğrulanmış COVID-19 olan toplam 937 çocuk olgu dahil edildi. Bulgular: Toplam 937 doğrulanmış COVID-19 vakası vardı. Toplamda, erkek olgular476’sını (%50.8) ve kız olgular 461’ini (%49.1) oluşturmuştur. Teyit edilen vakaların medyan yaşı 132.8 (0.5–215) ay idi. Toplam vakaların 50'si (%5.3) 1 yaşından küçük, 68’i (%7.3) 1-3 yaşında, 78'i (%8.3) 3-6 yaşında, 211'i (%22.5) 6-12 yaşında, 190'ı (%20.3) 12-15 yaş ve 340’ı (%36.3) 15 yaşından büyük idi. Başvuru anında 285 (%30.4) hastada herhangi bir semptom bulunmazken, hastaların 405’inin (%43.4) ilk ziyarette en sık görülen semptomu ateş ve öksürük idi. Diğer yaygın semptomlar ateş, öksürük ve ishal birlikteliği olan 50 (%5.3), tat ve koku kaybı 184 (%19.6), ateş ve febril nöbet birlikteliği 4 ( %0.4), öksürük ve nefes darlığı birlikteliği 5 (%0.5), solunum yetmezliği olan 2 (%0.2) olgu görüldü. Sonuç: Çocuk COVID-19 vakalarının çoğu hafif seyirlidir. Hastalar karakteristik belirtiler olarak kabul edilen ateş ve öksürük olmaksızın başvurabilir. Hastalarda görülen belirti ve bulgular yaşa göre değişkenlik gösterebilir.

Keywords

Covid 19, çocuk, epidemiyoloji, SARS-CoV-2

References

• 1. Eurosurveillance Editorial Team. Note from the editors: World Health Organization declares novel coronavirus (2019-nCoV) sixth public health emergency of international concern. Euro Surveill. 2020;25(5):200131e. doi:10.2807/1560-7917.ES.2020.25.5.200131e
• 2. Ladhani SN, Amin-Chowdhury Z, Davies HG, et al. COVID-19 in children: analysis of the first pandemic peak in England. Arch Dis Child. 2020;105(12):1180-1185. doi:10.1136/archdischild-2020-320042
• 3. Parri N, Lenge M, Buonsenso D; Coronavirus Infection in Pediatric Emergency Departments (CONFIDENCE) Research Group. Children with Covid-19 in Pediatric Emergency Departments in Italy. N Engl J Med. 2020;383(2):187-190. doi:10.1056/NEJMc2007617
• 4. Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239-1242. doi:10.1001/jama.2020.2648
• 5. Bi Q, Wu Y, Mei S, et al. Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: a retrospective cohort study [published correction appears in Lancet Infect Dis. 2020 Jul;20(7):e148]. Lancet Infect Dis. 2020;20(8):911-919. doi:10.1016/S1473-3099(20)30287-5
• 6. Sinha IP, Harwood R, Semple MG, et al. COVID-19 infection in children. Lancet Respir Med. 2020;8(5):446-447. doi:10.1016/S2213-2600(20)30152-1
• 7. Nikolopoulou GB, Maltezou HC. COVID-19 in Children: Where do we Stand?. Arch Med Res. 2022;53(1):1-8. doi:10.1016/j.arcmed.2021.07.002
• 8. Li H, Liu Z, Ge J. Scientific research progress of COVID-19/SARS-CoV-2 in the first five months. J Cell Mol Med. 2020;24(12):6558-6570. doi:10.1111/jcmm.15364
• 9. Dorjee K, Kim H, Bonomo E, Dolma R. Prevalence and predictors of death and severe disease in patients hospitalized due to COVID-19: A comprehensive systematic review and meta-analysis of 77 studies and 38,000 patients. PLoS One. 2020;15(12):e0243191. Published 2020 Dec 7. doi:10.1371/journal.pone.0243191
• 10. Chen J, Jiang Q, Xia X, et al. Individual variation of the SARS-CoV-2 receptor ACE2 gene expression and regulation. Aging Cell. 2020;19(7):e13168. doi:10.1111/acel.13168
• 11. Felsenstein S, Hedrich CM. COVID-19 in children and young people. Lancet Rheumatol. 2020;2(9):e514-e516. doi:10.1016/S2665-9913(20)30212-5
• 12. Lee PI, Hu YL, Chen PY, Huang YC, Hsueh PR. Are children less susceptible to COVID-19 J Microbiol Immunol Infect. 2020;53(3):371-372. doi:10.1016/j.jmii.2020.02.011
• 13. Lee PI, Hu YL, Chen PY, Huang YC, Hsueh PR. Are children less susceptible to COVID-19?. J Microbiol Immunol Infect. 2020;53(3):371-372. doi:10.1016/j.jmii.2020.02.011
• 14. Fang F, Luo XP. Zhonghua Er Ke Za Zhi. 2020;58(0):E001.doi:10.3760/cma.j.issn.0578-1310.2020.0001
• 15. Bunyavanich S, Do A, Vicencio A. Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults. JAMA. 2020;323(23):2427-2429. doi:10.1001/jama.2020.8707
• 16. National Center for Immunization and Respiratory Diseases (NCIRD), Division of Viral Diseases. CDC COVID-19 Science Briefs [Internet]. Atlanta (GA): Centers for Disease Control and Prevention (US); 2020-. Science Brief: Transmission of SARS-CoV-2 in K-12 Schools and Early Care and Education Programs – Updated. [Updated 2021 Dec 17]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK570438/
• 17. Cristiani L, Mancino E, Matera L, et all. Will children reveal their secret? The coronavirus dilemma. Eur Respir J, 2020 55: 2000749; doi: 10.1183/13993003.00749-2020
• 18. de Bree LCJ, Koeken VACM, Joosten LAB, et al. Non-specific effects of vaccines: Current evidence and potential implications. Semin Immunol. 2018;39:35-43. doi:10.1016/j.smim.2018.06.002
• 19. Benn CS, Netea MG, Selin LK, Aaby P. A small jab - a big effect: nonspecific immunomodulation by vaccines. Trends Immunol. 2013;34(9):431-439. doi:10.1016/j.it.2013.04.004
• 20. Jin XM, Xu X. [The Society of Pediatrics, Chinese Medical Association-an intensive training programme for developmental and behavioral pediatrics]. Zhonghua Er Ke Za Zhi. 2013 Nov;51(11):879-80. Chinese.
• 21. Karbuz A, Akkoc G, Bedir Demirdag T, et al. Epidemiological, Clinical, and Laboratory Features of Children With COVID-19 in Turkey. Front Pediatr. 2021;9:631547. Published 2021 May 7. doi:10.3389/fped.2021.631547
• 22. Lu X, Zhang L, Du H, et al. SARS-CoV-2 Infection in Children. N Engl J Med. 2020;382(17):1663-1665. doi:10.1056/NEJMc2005073
• 23. Dong Y, Mo X, Hu Y, et al. Epidemiology of COVID-19 Among Children in China. Pediatrics. 2020;145(6):e20200702. doi:10.1542/peds.2020-0702
• 24. Ding Y, Yan H, Guo W. Clinical Characteristics of Children With COVID-19: A Meta-Analysis. Front Pediatr. 2020;8:431. Published 2020 Jul 3. doi:10.3389/fped.2020.00431
• 25. Hoang A, Chorath K, Moreira A, et al. COVID-19 in 7780 pediatric patients: A systematic review. E Clinical Medicine. 2020;24:100433. Published 2020 Jun 26. doi:10.1016/j.eclinm.2020.100433
• 26. Korkmaz MF, Türe E, Dorum BA, Kılıç ZB. The Epidemiological and Clinical Characteristics of 81 Children with COVID-19 in a Pandemic Hospital in Turkey: an Observational Cohort Study. J Korean Med Sci. 2020;35(25):e236. Published 2020 Jun 29. doi:10.3346/jkms.2020.35.e236
• 27. Cura Yayla BC, Özsürekçi Y, Aykaç K, et al. Characteristics and Management of Children with COVID-19 in Turkey. Balkan Med J. 2020;37(6):341-347. doi:10.4274/balkanmedj.galenos.2020.2020.7.52
• 28. Mustafa NM, A Selim L. Characterisation of COVID-19 Pandemic in Paediatric Age Group: A Systematic Review and Meta-Analysis. J Clin Virol. 2020;128:104395. doi:10.1016/j.jcv.2020.104395
• 29. Götzinger F, Santiago-García B, Noguera-Julián A, et al. COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study. Lancet Child Adolesc Health. 2020;4(9):653-661. doi:10.1016/S2352-4642(20)30177-2
• 30. Xia W, Shao J, Guo Y, Peng X, Li Z, Hu D. Clinical and CT features in pediatric patients with COVID-19 infection: Different points from adults. Pediatr Pulmonol. 2020 May;55(5):1169-1174. doi: 10.1002/ppul.24718.