Amaç: Hepatit C virüsü nedenli kronik hepatitlerin prognozunda ve tedavisinde HCV genotipleri farklılık göstermektedir. Bu çalışmada; Mersin Şehir Eğitim ve Araştırma Hastanesi Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Bölümü’nde, kronik HCV enfeksiyonu tanısı ile takip edilen hastaların HCV genotip ve HCV-RNA değerlerinin değerlendirilmesi amaçlandı. Yöntem: Şubat 2017- Şubat 2022 tarihleri arasında Mersin Şehir Eğitim ve Araştırma Hastanesi Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Bölümü’nde kronik HCV enfeksiyonu tanısı ile takip edilen erişkin 202 hastanın yaş, cinsiyet, HCV-RNA ve genotip verileri hasta dosyaları ve hastane bilgi sistemi aracılığıyla retrospektif olarak değerlendirildi. HCV-RNA değerleri Bosphore Ultra HCV Quantification Detection Kiti ile HCV genotipleri Bosphore HCV Genotyping Kit v3 ile tespit edildi. Bulgular: Beş yıllık dönemde kronik HCV enfeksiyonu tanısı ile takip edilen erişkin 202 hastanın 60’ı (%29.7) kadın, 142’si (%70.3) erkekti. Yaş ortalaması 44.6±18.3 yıldı. Hastaların 65’inde (%32.1) genotip 1b, 53’ünde (%26.2) genotip 1a, 41’inde (%20.3) genotip 3, 24’ünde (%11.9) genotip 4, 11’inde (%5.4) genotip 2, 2’sinde (%1) genotip 5, 2’sinde (%1) genotip 3-4, 2’sinde (%1) genotip 1b-4, 1’inde (%0.5) genotip 2-3, 1’inde (%0.5) genotip 3-4 birlikteliği tespit edildi. 25 (%12.4) yabancı uyruklu hastada genotip 4 anlamlı derecede daha fazla tespit edildi (p<0.001). Ortanca HCV-RNA değeri 167.650 IU/ml (aralık: 105-19.526.197 IU/ml)’ydi. Genotipler arasında HCV-RNA düzeyleri açısından anlamlı bir ilişki saptanmadı. Kadınlarda genotip 1b anlamlı olarak daha fazla saptandı (p<0.05). Genotip 1’i olan hastaların yaş ortalaması diğer genotiplere göre daha yüksekti (48.5 yıl/39.4 yıl, p=0.003). Sonuç: Bölgemizde yabancı uyruklu hasta popülasyonunun son yıllarda artması nedeniyle, bölgemizde daha az görülen genotipler ve mikst tip HCV enfeksiyonlarında artış olması dikkat çekmektedir. HCV genotiplerinin belirlenmesinin, kronik HCV enfeksiyonlarının seyrinde ve tedavisinde yol göstermesi ayrıca bölgedeki HCV epidemiyolojisindeki değişiklikleri göstermesi açısından önemli olduğu düşünülmektedir.
Yok
Aim: HCV genotypes differ in the prognosis and treatment of chronic hepatitis caused by hepatitis C virüs. In this study; It was aimed to evaluate the HCV genotype and HCV-RNA values of the patients followed up with the diagnosis of chronic HCV infection in Mersin City Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology. Method: Age, gender, HCV-RNA and genotype data of 202 adult patients who were followed up with the diagnosis of chronic HCV infection in the Infectious Diseases and Clinical Microbiology Clinic of Mersin City Training and Research Hospital between February 2017 and February 2022 were evaluated retrospectively through patient files and hospital information system. HCV-RNA values were determined with Bosphore Ultra HCV Quantification Detection Kit and HCV genotypes were determined with Bosphore HCV Genotyping Kit v3. Results: Of the 202 patients followed up with chronic HCV infection in a five-year period, 60 (29.7%) were female and 142 (70.3%) were male. The mean age was 44.6±18.3 years. Of the patients, 65 (32.1%) were genotype 1b, 53 (26.2%) genotype 1a, 41 (20.3%) genotype 3, 24 (11.9%) genotype 4, 11 (5.4%) genotype 2, 2 (1%) genotype 5, 2 (1%) genotype 3-4, 2 (1%) genotype 1b-4, 1 (0.5%) genotype 2-3, 1 (0.5%) genotype 3-4 association was detected. Genotype 4 was significantly higher in 25 (12.4%) foreign nationals (p<0.001). The median HCV-RNA was 167,650 IU/ml (range: 105-19,526,197 IU/ml). There was no significant relationship between genotypes in terms of HCV-RNA levels. Genotype 1b was significantly higher in females (p<0.05). The mean age of patients with genotype 1 was significantly higher than the other genotypes (48.5 years/39.4 years, p=0.003). Conclusion: Due to the increase in the foreign national patient population in our region in recent years, it is noteworthy that the genotypes and mixed type HCV infections that are less common in our region are increasing. Determination of HCV genotypes is thought to be important in terms of guiding the course and treatment of chronic HCV infections and showing the changes in HCV epidemiology in the region.
Primary Language | Turkish |
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Subjects | Health Care Administration |
Journal Section | Articles |
Authors | |
Publication Date | April 30, 2023 |
Submission Date | October 6, 2022 |
Acceptance Date | January 7, 2023 |
Published in Issue | Year 2023 Volume: 16 Issue: 1 |
MEU Journal of Health Sciences Assoc was began to the publishing process in 2008 under the supervision of Assoc. Prof. Gönül Aslan, Editor-in-Chief, and affiliated to Mersin University Institute of Health Sciences. In March 2015, Prof. Dr. Caferi Tayyar Şaşmaz undertook the Editor-in Chief position and since then he has been in charge.
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