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Nekrotizan Enterokolit’in Erken Tanısında Gaitada Gizli Kan Tetkikinin Yeri

Year 2024, Volume: 17 Issue: 1 (özel sayı- MUSBD 2024; 17, özel sayı-1, 22. Mersin Pediatri Günleri Bildiri Kitabı), 105 - 109, 30.09.2024

Abstract

Amaç: Nekrotizan enterokolit (NEK)’li prematüre infantlarda çalışılan gaitada gizli kan testinin pozitif veya negatif olmasının doğum haftası, doğum kilosu ve NEK evresi ile olan ilişkisinin değerlendirilmesi yolu ile ilgili literatüre katkı sağlanması amaçlanmıştır. Yöntem: Çalışmaya Ocak 2018- Ocak 2024 tarihleri arasında Mersin Üniversitesi Tıp Fakültesi Yenidoğan Yoğun Bakım ünitesinde NEK tanısı ile tedavi edilen hastalar dahil edildi. NEK tanısı aldıkları dönemde gaitada gizli kan görülme durumları incelendi. NEK tanısı ve evrelemesi modifiye Bell sınıflamasına göre yapıldı. Gaitada gizli kan görülme durumları ile gestasyonel doğum haftaları ve doğum kiloları arasındaki ilişki İndipendent T-test ile incelendi. Ayrıca ilk tanı anında gaitada gizli kan görülme durumu ile NEK evreleri arasındaki ilişki ki-kare testi ile incelendi. Bulgular: Çalışmaya dahil edilen hastaların NEK evreleri, gestasyonel doğum haftaları ve doğum kiloları ile gaitada gizli kan görülme durumu arasında anlamlı bir ilişki tespit edilmedi (p=0.158), (p=0.339), (p=0.559). Sonuç: NEK’te gaitada gizli kan tetkikinin NEK evresi, gestasyonel doğum haftası ve doğum kiloları gibi belirteçler ile ilişkisinin zayıf olduğu düşünülmektedir.

Ethical Statement

Mersin Üniversitesi Sağlık Bilimleri Dergisi’nde yayımlanacak “Nekrotizan Enterokolit’in Erken Tanısında Gaitada Gizli Kan Tetkikinin Yeri” başlıklı çalışma kongrede sözlü bildiri olarak sunulmuş olup tam metin haline getirilmiştir .Bu gerekçeden ötürü etik kurul onamı gerekmemektedir. Bilgilerinize sunulur.

Supporting Institution

YOK

Thanks

YOK

References

  • Rees CM, Eaton S, Pierro A. National prospective surveillance study of necrotizing enterocolitis in neonatal intensive care units. J Pediatr Surg. 2010;45:13917. doi:10.1016/j.jpedsurg.2009.12.002.
  • Lemons JA, Bauer CR, Oh W, et al. Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, January 1995 through December 1996. Pediatrics. 2001;107:arte1.doi:10.1542/peds.107.1.e1.
  • Ahle M, Drott P, Andersson RE. Epidemiology and Trends of Necrotizing Enterocolitis in Sweden: 1987– 2009. Pediatrics. 2013;132:e443–51. doi:10.1542/peds.2012-3847.
  • Fitzgibbons SC, Ching Y, Yu D, et al. Mortality of necrotizing enterocolitis expressed by birth weight categories. J Pediatr Surg. 2009;44:1072-5. doi:10.1016/j.jpedsurg.2009.02.013.
  • Marion C. W. Henry, and R. Lawrence Moss. Surgical therapy for necrotizing enterocolitis: bringing evidence to the bedside. Seminars in Pediatric Surgery .2005; 14:181-190.
  • Niemarkt, H. J., de Meij, T. G., van de Velde, M. E., et al. Necrotizing enterocolitis: a clinical review on diagnostic biomarkers and the role of the intestinal microbiota. Inflammatory Bowel Diseases. 2015;21(2):436-444.
  • Abramo TJ, Evans JS, Kokomoor FW, Kantak AD. Occult blood in stools and necrotizing enterocolitis. Is there a relationship? Am J Dis Child. 1988;142:451452. doi:10.1001/archpedi.1988.02150040105030.
  • Lee J.S., Polin R.A., Treatment and prevention of necrotizing enterocolitis, Semin. Neonatol. 2003;8(6): 449–459.doi:10.1016/S1084-2756(03)00123-4
  • Pinheiro J.M.B., Clark D.A, Benjamin K.G. A critical analysis of the routine testing of newborn stools for occult blood and reducing substances. Advances in Neonatal Care. 2003;3(3): 133-138. doi:10.1016/S1536-0903(03)00073-0
  • Wen Q., Liu K., Yue W., et al. Clinical significance of positive fecal occult blood test in neonates. Scientific Reports. 2019;9(1):17898.doi: 10.1038/s41598-019-54511-5.
  • Stiles AD, Simpson B, Vaughn R, Thullen JT. Incidence of heme positive stools in a neonatal intensive care unit [abstract]. Pediatr Res. 1984;18:350A. doi:10.1203/00006450-198404001-01542.
  • Pickering A., White R., Davis N.L. Routine fecal occult blood testing does not predict necrotizing enterocolitis in very low birth weight neonates. Journal of neonatal-perinatal medicine. 2016;9(2): 171-17.

The role of fecal occult blood test in the early diagnosis of Necrotizing Enterocolitis

Year 2024, Volume: 17 Issue: 1 (özel sayı- MUSBD 2024; 17, özel sayı-1, 22. Mersin Pediatri Günleri Bildiri Kitabı), 105 - 109, 30.09.2024

Abstract

Aim: It was aimed to contribute to the relevant literature by evaluation the relationship between the positive or negative stool occult blood test result studied in the premature infants with necrotizing enterocolitis (NEC) and birth week, birth weight and NEC stage. Method: Patients diagnosed with NEC and treated at Mersin University Faculty of Medicine Neonatal Intensive Care Unit between January 2018 and January 2024 were included in the study. Occult blood in the stool was examined at the time they were diagnosed with NEC. The diagnosis and staging of NEC was made according to the modified Bell classification. The relationship between the occurrence of occult blood in the stool and gestational age and birth weight was examined with the Independent T-test. In addition, the relationship between the presence of occult blood in the stool at the time of initial diagnosis and the stages of NEC was examined with the chi-square test. Results: No significant relationship was detected between the presence of occult blood in the stool and the NEC stages, gestational birth weeks and birth weights of the patients included in the study (p=0.158), (p=0.339), (p=0.559). Conclusion: It is thought that the relationship between fecal occult blood examination and markers such as NEC stage, gestational age and birth weight is weak in NEC.

References

  • Rees CM, Eaton S, Pierro A. National prospective surveillance study of necrotizing enterocolitis in neonatal intensive care units. J Pediatr Surg. 2010;45:13917. doi:10.1016/j.jpedsurg.2009.12.002.
  • Lemons JA, Bauer CR, Oh W, et al. Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, January 1995 through December 1996. Pediatrics. 2001;107:arte1.doi:10.1542/peds.107.1.e1.
  • Ahle M, Drott P, Andersson RE. Epidemiology and Trends of Necrotizing Enterocolitis in Sweden: 1987– 2009. Pediatrics. 2013;132:e443–51. doi:10.1542/peds.2012-3847.
  • Fitzgibbons SC, Ching Y, Yu D, et al. Mortality of necrotizing enterocolitis expressed by birth weight categories. J Pediatr Surg. 2009;44:1072-5. doi:10.1016/j.jpedsurg.2009.02.013.
  • Marion C. W. Henry, and R. Lawrence Moss. Surgical therapy for necrotizing enterocolitis: bringing evidence to the bedside. Seminars in Pediatric Surgery .2005; 14:181-190.
  • Niemarkt, H. J., de Meij, T. G., van de Velde, M. E., et al. Necrotizing enterocolitis: a clinical review on diagnostic biomarkers and the role of the intestinal microbiota. Inflammatory Bowel Diseases. 2015;21(2):436-444.
  • Abramo TJ, Evans JS, Kokomoor FW, Kantak AD. Occult blood in stools and necrotizing enterocolitis. Is there a relationship? Am J Dis Child. 1988;142:451452. doi:10.1001/archpedi.1988.02150040105030.
  • Lee J.S., Polin R.A., Treatment and prevention of necrotizing enterocolitis, Semin. Neonatol. 2003;8(6): 449–459.doi:10.1016/S1084-2756(03)00123-4
  • Pinheiro J.M.B., Clark D.A, Benjamin K.G. A critical analysis of the routine testing of newborn stools for occult blood and reducing substances. Advances in Neonatal Care. 2003;3(3): 133-138. doi:10.1016/S1536-0903(03)00073-0
  • Wen Q., Liu K., Yue W., et al. Clinical significance of positive fecal occult blood test in neonates. Scientific Reports. 2019;9(1):17898.doi: 10.1038/s41598-019-54511-5.
  • Stiles AD, Simpson B, Vaughn R, Thullen JT. Incidence of heme positive stools in a neonatal intensive care unit [abstract]. Pediatr Res. 1984;18:350A. doi:10.1203/00006450-198404001-01542.
  • Pickering A., White R., Davis N.L. Routine fecal occult blood testing does not predict necrotizing enterocolitis in very low birth weight neonates. Journal of neonatal-perinatal medicine. 2016;9(2): 171-17.
There are 12 citations in total.

Details

Primary Language Turkish
Subjects Public Health (Other)
Journal Section Sözlü Bildiriler
Authors

İsa Kıllı 0000-0002-4370-9779

Ayşen Orman 0000-0003-1783-0185

Early Pub Date September 29, 2024
Publication Date September 30, 2024
Submission Date August 8, 2024
Acceptance Date August 19, 2024
Published in Issue Year 2024 Volume: 17 Issue: 1 (özel sayı- MUSBD 2024; 17, özel sayı-1, 22. Mersin Pediatri Günleri Bildiri Kitabı)

Cite

APA Kıllı, İ., & Orman, A. (2024). Nekrotizan Enterokolit’in Erken Tanısında Gaitada Gizli Kan Tetkikinin Yeri. Mersin Üniversitesi Sağlık Bilimleri Dergisi, 17(1 (özel sayı- MUSBD 2024; 17, özel sayı-1, 22. Mersin Pediatri Günleri Bildiri Kitabı), 105-109.
AMA Kıllı İ, Orman A. Nekrotizan Enterokolit’in Erken Tanısında Gaitada Gizli Kan Tetkikinin Yeri. Mersin Univ Saglık Bilim derg. September 2024;17(1 (özel sayı- MUSBD 2024; 17, özel sayı-1, 22. Mersin Pediatri Günleri Bildiri Kitabı):105-109.
Chicago Kıllı, İsa, and Ayşen Orman. “Nekrotizan Enterokolit’in Erken Tanısında Gaitada Gizli Kan Tetkikinin Yeri”. Mersin Üniversitesi Sağlık Bilimleri Dergisi 17, no. 1 (özel sayı- MUSBD 2024; 17, özel sayı-1, 22. Mersin Pediatri Günleri Bildiri Kitabı) (September 2024): 105-9.
EndNote Kıllı İ, Orman A (September 1, 2024) Nekrotizan Enterokolit’in Erken Tanısında Gaitada Gizli Kan Tetkikinin Yeri. Mersin Üniversitesi Sağlık Bilimleri Dergisi 17 1 (özel sayı- MUSBD 2024; 17, özel sayı-1, 22. Mersin Pediatri Günleri Bildiri Kitabı) 105–109.
IEEE İ. Kıllı and A. Orman, “Nekrotizan Enterokolit’in Erken Tanısında Gaitada Gizli Kan Tetkikinin Yeri”, Mersin Univ Saglık Bilim derg, vol. 17, no. 1, 22, pp. 105–109, 2024.
ISNAD Kıllı, İsa - Orman, Ayşen. “Nekrotizan Enterokolit’in Erken Tanısında Gaitada Gizli Kan Tetkikinin Yeri”. Mersin Üniversitesi Sağlık Bilimleri Dergisi 17/1, 22 (September 2024), 105-109.
JAMA Kıllı İ, Orman A. Nekrotizan Enterokolit’in Erken Tanısında Gaitada Gizli Kan Tetkikinin Yeri. Mersin Univ Saglık Bilim derg. 2024;17:105–109.
MLA Kıllı, İsa and Ayşen Orman. “Nekrotizan Enterokolit’in Erken Tanısında Gaitada Gizli Kan Tetkikinin Yeri”. Mersin Üniversitesi Sağlık Bilimleri Dergisi, vol. 17, no. 1 (özel sayı- MUSBD 2024; 17, özel sayı-1, 22. Mersin Pediatri Günleri Bildiri Kitabı), 2024, pp. 105-9.
Vancouver Kıllı İ, Orman A. Nekrotizan Enterokolit’in Erken Tanısında Gaitada Gizli Kan Tetkikinin Yeri. Mersin Univ Saglık Bilim derg. 2024;17(1 (özel sayı- MUSBD 2024; 17, özel sayı-1, 22. Mersin Pediatri Günleri Bildiri Kitabı):105-9.

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