The effect of alkaline reflux gasritis on intragastric pH and helicobacter pylori colonization

Abstract

Aim: The relationship between alkaline reflux gastritis and Helicobacter pylori remains unclear. It

is thought that bile and pancreatic fluids escaping into the stomach as a result of duodenogastric

reflux cause chemical irritation and pH changes in the gastric mucosa. However, the effect of

intragastric pH changes on Helicobacter pylori and duodenal contents on intragastric pH are not

known. The aim of this study was to investigate the relationship between intragastric pH and the

presence of Helicobacter pylori in patients with alkaline reflux gastritis.

Material and Methods: The patients who detected alkaline reflux gastritis (n = 30) and antral gastritis for the control group (n=35)

by gastroscopy were included in the study. During gastroscopy of all patients pH was measured from the liquid sample taken from

the stomach and rapid urease test was performed from the sample taken from the antrum.

Results: The mean intragastric pH in cases with alkaline reflux gastritis was similar to the control group (3.43±1.94, 3.2±2.02,

p=0.504, respectively). The rates of rapid urease test positivity were similar in both alkaline reflux gastritis and control groups

(p=0.461). Intragastric pH was found to be alkaline or acidic was not associated with rapid urease test positivity in both groups.

Conclusion: We believe that intragastric pH is acidic in patients with alkaline reflux gastritis too and both duodenogastric bile reflux

and intragastric pH changes have no effect on Helicobacter pylori colonization

Keywords

• Alkaline reflux,pH,helicobacter pylori,gastritis

Alkalen Reflü Gastritin İntragastrik pH ve Helicobacter Pylori Kolonizasyonu Üzerine Etkisi

Abstract

Amaç: Alkalen reflü gastrit ile Helicobacter pylori ilişkisi hâlen belirsizdir. Duodenogastrik reflü

sonucu mideye kaçan safra ve pankres sıvılarının mide mukozasında kimyasal irritasyon ve pH

değişikliklerine yol açtığı düşünülmektedir. Ancak intragastrik pH değişikliklerinin Helicobacter

pylori üzerine etkisi ve duodenum içeriğinin intragastrik pH’ya etkisi bilinmemektedir. Bu çalışmada

alkalen reflü gastrit hastalarında intragastrik pH ile Helicobacter pylori varlığı arasındaki ilişki

araştırılmıştır.

Gereç ve Yöntemler: Çalışmaya gastroskopide alkalen reflü gastrit tespit edilen (n=30) ve kontrol

grubu için antral gastrit tanısı alan hastalar (n=35) dahil edildi. Tüm hastalardan gastroskopi

esnasında mide içerisinden alınan sıvı örneğinden pH çalışıldı ve antrumdan alınan örnekten

üreaz testi yapıldı.

Bulgular: Alkalen reflü gastrit olgularında ortalama intragastrik pH kontrol grubu ile benzerdi

(Sırasıyla 3,43±1,94, 3,2±2,02, p=0,504). Hem Alkalen reflü gastrit grubunda hem de kontrol

grubunda üreaz testi pozitifliği oranları benzerdi (p=0,461). Her iki grupta intragastrik pH’nın alkali

veya asidik olması üreaz testi pozitifliği ile ilişkili değildi.

Sonuç: Alkalen reflü gastriti hastalarında da intragastrik pH’nın asidik olduğunu ve hem

duodenogastrik safra reflüsünün hem de intragastrik pH değişiklikliklerinin Helicobacter pylori

kolonozisyonu üzerine etkisi olmadığını düşünüyoruz.

Keywords

• Alkalen reflü,pH,,helikobakter pilori,gastrit

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