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Timing of Induction Onset in Nulliparous Term Pregnant Women with Premature Rupture of Membranes with Closed Cervix

Year 2020, Volume: 4 Issue: 1, 12 - 17, 30.04.2020

Abstract

Aim: To comparison of two applications used in our clinic in terms of timing of induction in
nulliparous pregnant women with premature rupture of membranes in terms of perinatal outcomes.

Material and Methods: The data of 100 patients admitted to our gynecology and obstetrics clinic with early rupture of membranes 

rupture between 2017-2019 were reviewed retrospectively. Age, gravida, parity, gestational age, delivery patterns, birth complications,

apgar scores of newborn babies, intensive care needs of newborn babies were recorded. As soon as early membrane rupture was
seen, patients were divided into two groups as immediate induction and those expected to have a maximum of 12 hours after early
membrane rupture. The comparison of the groups was done by Student t test for normal distributed data, Mann Whitney test for
normal non-distributed numerical data, and chi-square test for categorical data. p <0,05 was considered statistically significant.

Results: While the mean age of the patients in Group 1 was 27.4, the mean age of the patients in Group 2 was 28.2. There was no
statistically significant difference between the two groups in terms of age, gravida and birth week ( respectively p=0,145, p=0,902
and p=0,267). There was no statistically significant difference between the groups in terms of delivery types (p=1.000). There was
no statistically significant difference between the two groups in terms of birth complications (p=1.000). Patients in the early induction
group were born earlier than those in the late induction group. The difference between the two groups was statistically significant.

Conclusion: There was no difference in terms of poor perinatal outcomes when immediate induction and maximum 12 hours were
compared in terms of timing of induction in nulliparous term pregnants with closed cervix with premature rupture of membranes.


References

  • 1-)Seo K, McGregor JA, French JI. Infection and premature rupture of membranes. Fetal Med Rev 1990; 2:1-15
  • 2-) Bendon RW, Faye-Petersen O, Pavlova Z, Qureshi F, Mercer B, Miodovnik M, et al. Fetal membrane histology in preterm premature rupture of membranes: Comparison to controls and between antibiotic and placebo treatment. The National Institute of Child Health and Human Development Maternal Fetal Medicine Units Network. Pediatr Dev Pathol 1999; 2: 552-8.
  • 3-)French JI, McGregor JA. The pathobiology of premature rupture of membranes. Semin Perinatol 1996; 20: 344-368
  • 4-) Köşüş A, Köşüş N, Çapar M. Kliniğimizde erken membran rüptürü olan gebelerde perinatal sonuçlar. Turkiye Klinikleri J Gynecol Obst 2007, 17:152-158
  • 5-)Loeb LJ, Gaither K, Woo KS, Mason TC. Outcomes in gestations between 20 and 25 weeks with preterm premature rupture of membranes. South Med J 2006;99:709-12.
  • 6-) Thomas J, Garite MD. Premature rupture of membranes: The enigma of the obstetrician. Am J Obstet Gynecol 1985;151:1001-6.
  • 7-) Mozurkewich E. Prelabor rupture of membranes at term: Induction techniques. Clin Obstet Gynecol 2006;49:672-83.
  • 8-)ACOG Practice Bulletin No. 160: Premature Rupture of Membranes. Obstet Gynecol.2016 Jan;127(1):e39-51
  • 9-)August Fuhr N, Becker C, Van Baalen A, Bauer K, Hopp H. Antibiotic therapy for preterm premature rupture of membranes - results of a multicenter study. J Perinat Med 2006;34:203-6
  • 10-)von Dadelszen P, Kives S, Delisle MF, Wilson RD, Joy R, Ainsworth L, et al. The association between early membrane rupture, latency, clinical chorioamnionitis, neonatal infection, and adverse perinatal outcomes in twin pregnancies complicated by preterm prelabour rupture of membranes. Twin Res 2003; 6(4):257-62
  • 11-) Malik AS. Prelabour rupture of membranes and neonatal morbidity in level II nursery in Kelantan. 1994;49(1):12-6
  • 12-)Alcalay M, Hourvitz A, Reichman B, Luski A, Quint J, Barkai G, et al. Prelabour rupture of membranes at term: early induction of labour versus expectant management. Eur J Obstet Gynecol Reprod Biol 1996; 70(2): 129-33
  • 13-) Akyol D, Mungan T, Unsal A, Yüksel K. Prelabour rupture of the membranes at term--no advantage of delaying induction for 24 hours. 1999;39(3):291-5

Erken Membran Rüptürü Gelişen Kapalı Serviksli Nullipar Term Gebelerde İndüksiyon Başlama Süresinin Zamanlaması

Year 2020, Volume: 4 Issue: 1, 12 - 17, 30.04.2020

Abstract

Amaç: Erken membran rüptürü gelişen nullipar gebelerde indüksiyona başlama zamanlaması
açısından kliniğimizde kullanılan iki uygulamanın perinatal sonuçlar açısından karşılaştırılması.

Gereç ve Yöntemler: 2017-2019 yılları arasında hastanemiz kadın hastalıkları ve doğum
kliniğine erken memran rüptürü şikayeti ile başvuran toplam 100 hastanın verileri retrospektif
olarak tarandı. Hastaların yaş, gravida, parite, gebelik haftaları, doğum şekilleri, doğum
komplikasyonları, yeni doğan bebeklerin apgar skorları, yeni doğan bebeklerin yoğun bakım
ihtiyaçları, kayıt altına alındı. Hastalar erken membran rüptürü görülür görülmez hemen indüksiyon
başlananlar ve erken membran rüptürü görülmesi ardından en fazla 12 saat beklenenler olarak
iki gruba ayrıldı. Grupların kıyaslanması normal dağılan numerik verilerde Student t testi, normal
dağılmayan numerik verilerde Mann Whitney testi, kategorik verilerde ki-kare testi ile yapıldı.
p<0,05 istatistiksel olarak anlamlı olarak kabul edildi.

Bulgular: Grup 1’ deki hastaların yaş ortalaması 27,4 iken, Grup 2’ deki hastaların yaş ortalaması
28,2 idi. İki grup arasında arasında yaş, gravida, doğum haftası açısından istatistiksel olarak
anlamlı bir fark izlenmedi (sırasıyla p=0,145, p=0,902 ve p=0,267). Doğum şekilleri açısından
gruplar arasında istatistiksel olarak anlamlı fark izlenmemiştir (p=1.000). Doğum komplikasyonları
açısından her iki grup arasında istatistiksel olarak anlamlı fark izlenmemiştir (p=1.000). Erken
indüksiyon başlanan gruptaki hastalar, geç indüksiyon başlanan gruptaki hastalara göre daha
erken doğurmuştur. Doğuma kadar geçen süreler bakımından her iki grup arasındaki fark
istatistiksel olarak anlamlıdır.

Sonuç: Erken membran rüptürü gelişen kapalı serviksli nullipar term gebelerde indüksiyon
başlama zamanlaması açısından hemen indüksiyon başlanması ile en fazla 12 saat beklenmesi
karşılaştırıldığında kötü perinatal sonuçlar açısından aralarında fark izlenmedi.

References

  • 1-)Seo K, McGregor JA, French JI. Infection and premature rupture of membranes. Fetal Med Rev 1990; 2:1-15
  • 2-) Bendon RW, Faye-Petersen O, Pavlova Z, Qureshi F, Mercer B, Miodovnik M, et al. Fetal membrane histology in preterm premature rupture of membranes: Comparison to controls and between antibiotic and placebo treatment. The National Institute of Child Health and Human Development Maternal Fetal Medicine Units Network. Pediatr Dev Pathol 1999; 2: 552-8.
  • 3-)French JI, McGregor JA. The pathobiology of premature rupture of membranes. Semin Perinatol 1996; 20: 344-368
  • 4-) Köşüş A, Köşüş N, Çapar M. Kliniğimizde erken membran rüptürü olan gebelerde perinatal sonuçlar. Turkiye Klinikleri J Gynecol Obst 2007, 17:152-158
  • 5-)Loeb LJ, Gaither K, Woo KS, Mason TC. Outcomes in gestations between 20 and 25 weeks with preterm premature rupture of membranes. South Med J 2006;99:709-12.
  • 6-) Thomas J, Garite MD. Premature rupture of membranes: The enigma of the obstetrician. Am J Obstet Gynecol 1985;151:1001-6.
  • 7-) Mozurkewich E. Prelabor rupture of membranes at term: Induction techniques. Clin Obstet Gynecol 2006;49:672-83.
  • 8-)ACOG Practice Bulletin No. 160: Premature Rupture of Membranes. Obstet Gynecol.2016 Jan;127(1):e39-51
  • 9-)August Fuhr N, Becker C, Van Baalen A, Bauer K, Hopp H. Antibiotic therapy for preterm premature rupture of membranes - results of a multicenter study. J Perinat Med 2006;34:203-6
  • 10-)von Dadelszen P, Kives S, Delisle MF, Wilson RD, Joy R, Ainsworth L, et al. The association between early membrane rupture, latency, clinical chorioamnionitis, neonatal infection, and adverse perinatal outcomes in twin pregnancies complicated by preterm prelabour rupture of membranes. Twin Res 2003; 6(4):257-62
  • 11-) Malik AS. Prelabour rupture of membranes and neonatal morbidity in level II nursery in Kelantan. 1994;49(1):12-6
  • 12-)Alcalay M, Hourvitz A, Reichman B, Luski A, Quint J, Barkai G, et al. Prelabour rupture of membranes at term: early induction of labour versus expectant management. Eur J Obstet Gynecol Reprod Biol 1996; 70(2): 129-33
  • 13-) Akyol D, Mungan T, Unsal A, Yüksel K. Prelabour rupture of the membranes at term--no advantage of delaying induction for 24 hours. 1999;39(3):291-5
There are 13 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Research Article
Authors

İsa Şükrü Öz 0000-0001-8849-2705

Besim Haluk Bacanakgıl This is me 0000-0002-4723-7297

Publication Date April 30, 2020
Acceptance Date April 29, 2020
Published in Issue Year 2020 Volume: 4 Issue: 1

Cite

Vancouver Öz İŞ, Bacanakgıl BH. Erken Membran Rüptürü Gelişen Kapalı Serviksli Nullipar Term Gebelerde İndüksiyon Başlama Süresinin Zamanlaması. Med J West Black Sea. 2020;4(1):12-7.

Medical Journal of Western Black Sea is a scientific publication of Zonguldak Bulent Ecevit University Faculty of Medicine.

This is a refereed journal, which aims at achieving free knowledge to the national and international organizations and individuals related to medical sciences in publishedand electronic forms.

This journal is published three annually in April, August and December.
The publication language of the journal is Turkish and English.