The Effect of Maternal MTHFR C677T Gene Mutation Presence on Neonatal Birth Weight

Abstract

Aim: MTHFR (methylenetetrahydrofolate
reductase) gene mutation may diminish
MTHFR activity and result in an increased
homocystein level. It is thought that MTHFR
gene mutation may cause intrauterine growth
restriction. The aim of this study is to evaluate
the effect of maternal MTHFR gene mutatıon
presence on neonatal birth weights.
Materials and Methods: The study
population consists of MTHFR gene mutation
group (n=71) and control group (n=36).
Neonatal birth weights were compared
between groups.
Results: 107 pregnant women applying to
Mustafa Kemal University Hospital were
included in this study. Neonatal birth weights
were lower in MTHFR gene mutatıon group
than in control group.
Conclusion: Our study result showed that
neonatal birth weights were lower in MTHFR
gene mutation group than in control group.
Neonatal care may be necessary for newborn
of mothers having MTHFR gene mutation.
Further studies are needed to investigate the
relation between MTHFR gene mutation and
neonatal birth weight.

Keywords

• methylenetetrahydrofolate reductase
• neonatal birth weight
• Gene Mutation

Maternal MTHFR C677T Gen Mutasyonu Varlığının Yenidoğan Doğum Ağırlığı Üzerine Etkisi

Abstract

Amaç: MTHFR (metilentetrahidrofolat redüktaz) gen mutasyonu, MTHFR aktivitesinin azalmasına ve homosistein düzeyinde artışa neden olur. MTHFR gen mutasyonunun intrauterin büyümede yavaşlamaya neden olduğu düşünülmektedir. Bu çalışmada MTHFR gen mutasyonu olan gebelerden doğan yenidoğanların doğum kilolarını mutasyonu olmayan gebelerden doğan populasyonla karşılaştırmayı amaçladık.
Materyal-Metod: Çalışma grubu MTHRF gen mutasyonu (n=71) grubundan ve kontrol grubundan (n=36) oluşmaktaydı. Yenidoğan doğum ağırlıkları gruplar arasında karşılaştırıldı.
Bulgular: Kadın Hastalıkları ve Doğum polikliniğine incelenen dönemde başvuran ve MTHFR gen analizi bakılmış olan toplam 107 gebe değerlendirilmişti. Yenidoğan doğum ağırlıkları MTHRF gen mutasyonu grubunda, kontrol grubuna göre daha düşük bulunmuştur.
Sonuç: MTHFR mutasyonu olan kadınlardan doğan yenidoğanların doğum kilolarının normal populasyona göre daha düşük olduğu görülmüştür. Bu olguların yenidoğan yoğun bakım ünitesi olan bir merkezde doğum yapması uygun olacaktır. MTHFR mutasyonu ve yenidoğanların doğum kilolarının arasındaki ilişkiyi araştıran ileri çalışmalara ihtiyaç vardır.

Keywords

• Metilentetrahidrofolat redüktaz
• yenidoğan doğum ağırlığı
• gen mutasyonu

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