Retrospective Analysis and Literature Review of Acute Tubulointerstitial Nephritis Cases Linked to Energy Drinks

Abstract

Objective: Acute tubulointerstitial nephritis (aTIN) is a rare cause of acute renal injury in children. The incidence of cases linked to insensible use of energy drinks has increased in recent years. In thıs study, we aimed to examine patients with aTIN connected to energy drink in detail in our own patients.Methods: In this study, the files of patients with acute tubulointerstitial nephritis (aTIN in the pediatric nephrology clinic were retrospectively screened.Results: 32 patients were included in the study (F/M: 22/10). Mean age was 12±4.3 years (9-17). The most common causes in etiology were drugs (18; 56.2%) and energy drinks (9; 28.1%). The most common attendance symptoms were vomiting (84.3%), fatigue (68.7%), hypertension (56.2%), abdominal pain (40.6%), joint pain (34.3%), fever (31.2%). The mean duration from onset of symptoms to first attendance at hospital was 3.8±2.1 days, with the mean duration between first intake of causative agent to onset of symptoms 9±4.1 days.Conclusion: The inclusion of energy drink use among candidates for causes of aTIN in recent years is an important health problem. Due to serious side effect profile beginning with acute kidney injury and resulting in CKD, it is a cause that should definitely be questioned in the anamnesis of young patients especially.

Keywords

• Acute Tubulointerstitial Nephritis
• Energy Drinks
• Prognosis

Enerji İçeceklerine Bağlı Akut Tubulointerstisyel Nefrit Vakalarının Retrospektif Analizi ve Literatür Taraması

Abstract

Amaç: Akut tubulointerstisyel nefrit (aTIN), çocuklarda akut böbrek hasarının nadir bir nedenidir. Enerji içeceklerinin bilinçsiz kullanımına bağlı vakaların görülme sıklığı son yıllarda artmıştır. Bu çalışmada ATN tanısı alan tüm hastalarımız ile birlikte enerji içeceğine bağlı aTIN’ li hastaları detaylı olarak incelemeyi amaçladık.Yöntem: Bu çalışmada çocuk nefroloji kliniğinde izlenen akut tubulointerstisyel nefrit (aTIN) hastalarının dosyaları geriye dönük olarak tarandı.Bulgular: Çalışmaya 32 hasta dahil edildi (K/E: 22/10). Ortalama yaş 12 ± 4,3 yıl (9-17) idi. Etiyolojide en sık nedenler ilaçlar (18; % 56.2), enerji içecekleri (9; % 28.1) idi. En sık görülen başvuru semptomları kusma (%84.3), yorgunluk (% 68.7), hipertansiyon (% 56.2), karın ağrısı (%40,6), eklem ağrısı (%34.3), ateş (%31.2) idi. Etken madde alımı ile semptomların başlangıcı arasındaki ortalama süre 9 ± 4,1 gündü.Sonuç: Enerji içeceği kullanımının son yıllarda aTIN nedenleri arasında yer alması önemli bir sağlık sorunudur. Akut böbrek hasarı ile başlayan ve KBH ile sonuçlanan ciddi yan etki profili nedeniyle özellikle genç hastaların anamnezinde mutlaka sorgulanması gereken bir nedendir.

Keywords

• Akut Tubolointerstisyel Nefrit
• Enerji İçeceği
• Prognoz

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