The Role of Systemic Inflammatory Markers in the Diagnosis of Hyperemesis Gravidarum

Year 2020, Volume: 7 Issue: 3, 124 - 127, 29.12.2020

Süleyman Cemil Oğlak , Mehmet Obut

https://doi.org/10.47572/muskutd.677093

Cited By: 1

Abstract

This study was aimed to investigate the diagnostic value of the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), platelet distribution width (PDW), mean platelet volume (MPV), plateletcrit (PCT) and red cell distribution width (RDW) in patients with hyperemesis gravidarum (HG). We conducted this retrospective study in a tertiary center between August and December 2019.A total of 72 pregnant patients with HG and 78 pregnant women without nausea and vomiting were included in the study. Hemoglobin (Hb), white blood cell count (WBC), neutrophil count, lymphocyte count, platelet count, RDW, PDW, MPV, PCT, and CRP values were all derived from patients' medical files. The student's t-test was used to compare the normally distributed data. Mann-Whitney U test was used to compare the non-normally distributed data. The median NLR value of the HG group was 3.4 (1.1-7.2), and the control group was 1.98 (1.0-4.6). This difference was statistically significant (p<0.05). The median PLR value of the HG group (152.6 [69.8-338.1]) was significantly higher (p<0.05) than the PLR value of the control group (88.1 [48.3-201.2]). The results of this study suggest that NLR and PLR can be used as effective markers in the diagnosis of HG. The increased values of NLR and PLR also indicate that inflammation may act a crucial role in the pathogenesis of HG.

Keywords

Neutrophil-Lymphocyte Ratio, Platelet-Lymhocyte Ratio, Systemic Inflammatory Markers, Hyperemesis Gravidarum

Sistemik İnflamatuar Belirteçlerin Hyperemezis Gravidarum Tanısındaki Rolü

Abstract

Bu çalışmada hiperemezis gravidarumu olan hastalarda nötrofil-lenfosit oranı (NLO), trombosit-lenfosit oranı (TLO), trombosit dağılım genişliği (TDG), ortalama trombosit hacmi (OTH), plateletcrit (PKT) ve eritrosit dağılım genişliğinin (EDG) tanısal değeri araştırılmıştır. Bu retrospektif çalışmayı üçüncü basamak bir merkezde Ağustos ve Aralık 2019 tarihleri arasında gerçekleştirdik. Çalışmaya hiperemezis gravidarumu olan 72 hasta ve bulantı ve kusması olmayan 78 gebe dahil edildi. Hemoglobin (Hb), EDG, TDG, OTH, PKT ve C-reaktif protein (CRP) değerleri hastaların tıbbi dosyalarından elde edildi. Normal dağılım gösteren verileri karşılaştırmak için Student's t testi, normal dağılıma uymayan verileri karşılaştırmak için Mann-Whitney U testi kullanıldı. HG grubunun ortanca NLO değeri 3.4 (1.1-7.2), kontrol grubunun 1.98 (1.0-4.6) idi. Bu farklılık istatistiksel olarak anlamlıydı (p<0.05). HG grubunun ortanca PLO değeri (152.6 [69.8-338.1]), kontrol grubunun PLO değerinden (88.1 [48.3-201.2]) anlamlı olarak daha yüksekti (p<0.05). Bu çalışmanın sonuçları NLO ve PLO’nun HG tanısında etkili belirteçler olarak kullanılabileceğini düşündürmektedir. Artan NLO ve PLO değerleri, inflamasyonun HG patogenezinde önemli bir rol oynuyor olabileceğini de göstermektedir.

Keywords

Nötrofil-Lenfosit Oranı, Platelet-Lenfosit Oranı, Sistemik İnflamatuar Belirteçler, Hyperemesis Gravidarum

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