The Effect of Histopathological Subtype on 5 Year and 10 Year Overall Survival in Primary Malign Tumors of the Chest Wall

Year 2023, Volume: 10 Issue: 3, 160 - 170, 19.12.2023

Burak Odabaşı , Mehmet Yıldırım İsmail Dal , M. Didem Aydemir Kemal Demircan Deniz Ezgi Mahmutoğlu , Seçkin Deniz Semih Buluklu Aybiyçe E. Silpağar Murat Yaşaroğlu Bülent Aydemir Tamer Okay

https://doi.org/10.47572/muskutd.1311039

Abstract

Primary tumors of the chest wall are rare tumors comprising 5% of thoracic neoplasms. The current study was designed to evaluate the effect of histopathological subtype on the 5-year and 10-year overall survival and regional recurrence in primary malignant tumors of the chest wall. From December 2007 to December 2019, the data of 20 patients were analyzed. Overall survival rates, median overall survival, regional tumor recurrence and median disease-free survival rates were compared retrospectively between histopathological subtypes. Chondrosarcoma (n=7), desmoid tumor (n=6), undifferentiated pleomorphic sarcoma [(UPS), (n=4)], Ewing's sarcoma (n=1), malignant peripheral nerve sheath tumor (n=1), and liposarcoma (n=1) were the subtypes identified. A lower median overall survival was detected in the UPS histopathological subtype (p = 0.004). The 5 and 10-year overall survival rates in the chondrosarcoma group were 71% and 37%, respectively; desmoid tumors were found in 83% and 42%, respectively. There was no patient with 5-year survival in UPS. A shorter median overall survival was found in lateral wall masses compared to anterior and posterior wall masses (p = 0.001). During the follow-up, 10 patients (50%) died. It was observed that the median disease-free survival in the UPS subtype was shorter compared to the other subtypes (p = 0.002). The regional recurrence rate was 57%, 17% and 75% in chondrosarcoma, desmoid tumor and UPS, respectively. In UPS, a primary malignant tumor of the chest wall, 5-year and 10-year overall survival rates and median overall survival; it was found to be significantly shorter than the chondrosarcoma and desmoid tumor groups.

Keywords

Chest Wall Primary Malignant Tumor, Overall Survival, Regional Recurrence, Undifferentiated Pleomorphic Sarcoma

Göğüs Duvarının Primer Malign Tümörlerinde Histopatolojik Alt Tipin 5 Yıllık ve 10 Yıllık Genel Sağkalıma Etkisi

Abstract

Göğüs duvarının primer tümörleri, torasik neoplazmların %5'ini oluşturan nadir tümörlerdir. Mevcut çalışma, göğüs duvarının primer malign tümörlerinde histopatolojik alt tipin 5 yıllık ve 10 yıllık genel sağkalıma ve bölgesel nüks durumlarına etkisini değerlendirmeye yönelik tasarlanmıştır. Aralık 2007’den Aralık 2019’a kadar, 20 hastanın verileri geriye dönük olarak incelendi. Histopatolojik alt tipler arasında; genel sağkalım oranları, ortanca sağkalım, bölgesel tümör nüksü saptanma oranları ve ortanca hastalıksız sağkalım geriye dönük olarak kıyaslandı. Kondrosarkom (n=7), desmoid tümör (n=6), indiferansiye pleomorfik sarkom [(İPS), (n=4)], Ewing sarkomu (n=1), malign periferik sinir kılıf tümörü (n=1) ve liposarkom (n=1) tespit edilen alt tiplerdi. İPS histopatolojik alt tipinde daha düşük ortanca sağkalım tespit edildi (p = 0.004). Kondrosarkom grubunda 5 ve 10 yıllık genel sağkalım oranları sırasıyla, %71 ve %37; desmoid tümörlerde sırasıyla, %83 ve %42 saptandı. İPS’de ise 5 yıllık sağkalım gösteren hasta olmadı. Yan duvar yerleşimli kitlelerde, ön ve arka duvar yerleşimli kitlelere kıyasla daha kısa ortanca sağkalım tespit edildi (p = 0.001). Takip süresince 10 hasta (%50) hayatını kaybetti. İPS alt tipinde ortanca hastalıksız sağkalımın, diğer alt tiplere kıyasla daha kısa olduğu görüldü (p = 0.002). Bölgesel nüks oranları, kondrosarkom, desmoid tümör ve İPS için sırasıyla, %57; %17 ve %75 olarak saptandı. Göğüs duvarının primer malign tümörlerinden İPS’de, 5 yıllık ve 10 yıllık genel sağkalım oranlarının ve ortanca sağkalımın; kondrosarkom ve desmoid tümör gruplarına kıyasla anlamlı ölçüde daha kısa olduğu saptandı.

Keywords

Bölgesel Nüks, Genel Sağkalım, Göğüs Duvarı Primer Malign Tümörü, İndiferansiye Pleomorfik Sarkom

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