Encapsulation of Some Flavonoid Mixtures Using Electrospinning Technique for Enhanced Bioactivity and Controlled Release Studies

Deniz Tuğçe Algan; Erdal Kocabaş

TR EN

Artırılmış Biyoaktivite için Bazı Flavonoid Karışımlarının Elektroeğirme Tekniği Kullanılarak Enkapsülasyonu ve Kontrollü Salım Çalışmaları

Abstract

Narenciye meyvelerinden elde edilen biyoaktif bileşikler olan rutin hidrat, naringin ve hesperidin kullanılarak polimer bazlı elektroeğirme fiberleri hazırlanmıştır. Bu flavonoidlerin antioksidan, anti-inflamatuar ve anti-kanser gibi çeşitli biyolojik aktiviteleri bulunmaktadır. Elektroeğirme tekniği sayesinde, flavonoidlerin biyolojik kullanılabilirliği artırılarak, ilaç taşıma sistemleri, gıda ambalajları ve kozmetik ürünler gibi farklı alanlarda potansiyel uygulamalar geliştirilmesi amaçlanmıştır. Elde edilen fiberlerin morfolojik ve kimyasal ve karakterizasyonları ile flavonoidlerin fiber matris içerisindeki dağılımı ve salım davranışları belirlenmiştir. Aynı zamanda, nanofiberlerin Staphylococcus aureus (S. aureus) bakterisine karşı antibakteriyel aktivitesi değerlendirildi. Yapılan çalışmanın sonucunda bağırsak pH’ında (pH 7,4) yapılan dissolüsyon analizinde PLA-MIX fiberi etken maddeleri %20-25 oranında, PCL- MIX fiberi etken maddeleri %21-28 oranında salındı. Antibakteriyel sonuçlar nanofiberlerin %45 oranında PLA karışımında daha fazla bakteriyel inhibisyona neden olduğunu gösterdi. Bu çalışma, narenciye atıklarının değerlendirilmesi ve yeni nesil biyomalzemelerin geliştirilmesi açısından önemli bir katkı sağlamaktadır.

Keywords

Antibakteriyel etki, Elektroeğirme, Flavonoid, Hesperidin, in vitro ilaç salım, Naringin, Rutin hidrat

Encapsulation of Some Flavonoid Mixtures Using Electrospinning Technique for Enhanced Bioactivity and Controlled Release Studies

Abstract

Polymer-based electrospun fibers were prepared using bioactive compounds derived from citrus fruits such as rutin hydrate, naringin and hesperidin. These flavonoids have various biological activities such as antioxidant, anti-inflammatory and anticancer. By increasing the bioavailability of flavonoids through the electrospinning technique, it is aimed to develop potential applications in different areas such as drug delivery systems, food packaging and cosmetic products. The distribution and release behaviors of flavonoids in the fiber matrix were determined by morphological and chemical characterization of the obtained fibers. At the same time, the antibacterial activity of nanofibers against Staphylococcus aureus (S. aureus) bacteria was evaluated. As a result of the study, in the dissolution analysis performed at intestinal pH (pH 7.4), the active ingredients of PLA-MIX fiber were released at a rate of 20-25% and PCL-MIX fiber at a rate of 21-28%. Antibacterial results showed that nanofibers caused more bacterial inhibition in a 45% PLA mixture. This study provides an important contribution to the evaluation of citrus wastes and the development of new-generation biomaterials.

Keywords

Antibacterial effect, Electrospinning, Flavonoid, Hesperidin, in vitro drug release, Naringin, Rutin hydrate

Supporting Institution

TÜBİTAK and Necmettin Erbakan University

Project Number

119C100 and NEÜBAP-221415002

Ethical Statement

This article is the revised and developed version of the unpublished conference presentation entitled “Polymer-Based Encapsulation of Flavonoids via Electrospinning for Nutraceutical Applications," presented as a poster at the 6th International Congress on Biosensors.

Thanks

I would like to thank Assoc. Prof. Dr. Fatih Erci and masters student Hala Boubaker, members of the Biotechnology Department of the Faculty of Science at Necmettin Erbakan University, for antibacterial activity assay experiments.

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Details

Primary Language

English

Subjects

Natural Products and Bioactive Compounds

Journal Section

Research Article

Authors

Deniz Tuğçe Algan ^*
0000-0002-0085-4327
Türkiye

Erdal Kocabaş
0000-0002-0980-0894
Türkiye

Early Pub Date

April 28, 2025

Publication Date

April 30, 2025

Submission Date

September 25, 2024

Acceptance Date

November 1, 2024

Published in Issue

Year 2025 Volume: 7 Number: 1

IZ

https://izlik.org/JA29BY37KY

APA

Algan, D. T., & Kocabaş, E. (2025). Encapsulation of Some Flavonoid Mixtures Using Electrospinning Technique for Enhanced Bioactivity and Controlled Release Studies. Necmettin Erbakan University Journal of Science and Engineering, 7(1), 141-152. https://izlik.org/JA29BY37KY

AMA

1.Algan DT, Kocabaş E. Encapsulation of Some Flavonoid Mixtures Using Electrospinning Technique for Enhanced Bioactivity and Controlled Release Studies. NEJSE. 2025;7(1):141-152. https://izlik.org/JA29BY37KY

Chicago

Algan, Deniz Tuğçe, and Erdal Kocabaş. 2025. “Encapsulation of Some Flavonoid Mixtures Using Electrospinning Technique for Enhanced Bioactivity and Controlled Release Studies”. Necmettin Erbakan University Journal of Science and Engineering 7 (1): 141-52. https://izlik.org/JA29BY37KY.

EndNote

Algan DT, Kocabaş E (April 1, 2025) Encapsulation of Some Flavonoid Mixtures Using Electrospinning Technique for Enhanced Bioactivity and Controlled Release Studies. Necmettin Erbakan University Journal of Science and Engineering 7 1 141–152.

IEEE

[1]D. T. Algan and E. Kocabaş, “Encapsulation of Some Flavonoid Mixtures Using Electrospinning Technique for Enhanced Bioactivity and Controlled Release Studies”, NEJSE, vol. 7, no. 1, pp. 141–152, Apr. 2025, [Online]. Available: https://izlik.org/JA29BY37KY

ISNAD

Algan, Deniz Tuğçe - Kocabaş, Erdal. “Encapsulation of Some Flavonoid Mixtures Using Electrospinning Technique for Enhanced Bioactivity and Controlled Release Studies”. Necmettin Erbakan University Journal of Science and Engineering 7/1 (April 1, 2025): 141-152. https://izlik.org/JA29BY37KY.

JAMA

1.Algan DT, Kocabaş E. Encapsulation of Some Flavonoid Mixtures Using Electrospinning Technique for Enhanced Bioactivity and Controlled Release Studies. NEJSE. 2025;7:141–152.

MLA

Algan, Deniz Tuğçe, and Erdal Kocabaş. “Encapsulation of Some Flavonoid Mixtures Using Electrospinning Technique for Enhanced Bioactivity and Controlled Release Studies”. Necmettin Erbakan University Journal of Science and Engineering, vol. 7, no. 1, Apr. 2025, pp. 141-52, https://izlik.org/JA29BY37KY.

Vancouver

1.Deniz Tuğçe Algan, Erdal Kocabaş. Encapsulation of Some Flavonoid Mixtures Using Electrospinning Technique for Enhanced Bioactivity and Controlled Release Studies. NEJSE [Internet]. 2025 Apr. 1;7(1):141-52. Available from: https://izlik.org/JA29BY37KY

Artırılmış Biyoaktivite için Bazı Flavonoid Karışımlarının Elektroeğirme Tekniği Kullanılarak Enkapsülasyonu ve Kontrollü Salım Çalışmaları

Abstract

Keywords

Encapsulation of Some Flavonoid Mixtures Using Electrospinning Technique for Enhanced Bioactivity and Controlled Release Studies

Abstract

Keywords

Supporting Institution

Project Number

Ethical Statement

Thanks

References

Details

Primary Language

Subjects

Journal Section

Authors

Early Pub Date

Publication Date

Submission Date

Acceptance Date

Published in Issue

IZ

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