İnsan Sağlığındaki Eşsiz Hazine: Humik Asitler

Öz

Sağlıklı yaşamın devamı ve yaşam kalitesini yükseltmek için kimyasal içeren ve sentetik ürünlerden ziyade doğal kaynaklara yönelim hızla devam etmektedir. Doğal besinlerin kullanımı, hastalıkların doğal yollarla tedavi edilmeye çalışılması geçmişten günümüze insanların her zaman ilgisini çekmiş ve minimum kimyasal kullanımı ile dışa bağımlılığın azaltılması için doğal kaynaklara yönelim ivme kazanmıştır. Bu amaçla insanlar doğal kaynak ve organik besin arayışına girmiştir. Bu kaynakların arasında ülkemizde bolca bulunan ama çok fazla bilinmeyen veya bilinmesine rağmen kullanımında tereddüt edilen gizli hazine humik asittir. Humik asitler klasik olarak tarım alanlarında organik gübre ve bitki besleme ajanı olarak kullanımlarıyla bilinse de çok yönlülüğü sayesinde endüstri, çevre, kozmetik ve biyotıp gibi alanlarda ham madde olarak kullanılmaktadır. Bu denli uygulama alanı bulabilen humik asitler, doğal kaynak olması nedeniyle hem günümüz endüstrisinde hem de birçok farklı alanda kullanılabilecek potansiyeldedir.

Anahtar Kelimeler

• humik asitler
• insan sağlığı
• cilt problemleri
• deri hastalıkları
• genel sağlık

The Unique Treasure in Human Health: Humic Acids

Abstract

In order to maintain a healthy life and improve the quality of life, the trend towards natural resources rather than synthetic products containing many chemicals continues rapidly. Factors such as the use of natural foods and the treatment of diseases naturally have always attracted people's attention and factors such as the reduction of external dependence with minimum use of chemicals have accelerated the orientation towards natural resources. For this purpose, people are in search of natural resources and organic foods. Among these sources, which is abundant in our country but is not known or hesitated to be known and used, is humic acid. Although humic acids are known for their use as organic fertilizers in agricultural areas, they are used in fields such as industry, environment, cosmetics and biomedicines thanks to their versatility. Humic acids, which can find such application areas, have the potential to be used both in today's industry and in many different fields due to their natural resources.

Keywords

• Humic acids
• Human health
• Skin problems
• Skin diseases
• General health

References

1. Achard FK., Chemische untersuchng des torfs. Crell's Chemische Annalen 1786; 11(2): 391-403.
2. Aladaş A. Koyunlarda kırkım öncesi C vitamini ve humik asit uygulamasının kırkım stresini azaltmasındaki etkisinin incelenmesi. Afyon Kocatepe Üniversitesi Sağlık Bilimleri Enstitüsü Yüksek Lisans Tezi, Afyon, Türkiye, 2013.
3. Amosava Y., Kosyanova ZF., Orlov DS., Tikhomirova KS., Shinkarenko AL. Humic acids in the therapeutic muds with a special reference to their physiological activity. Voprosy Kurortologii, Fizioterapii, i Lechebnoi Fizicheskoi Kultury 1990; 27(4): 1-6.
4. Anonymous, 2017. Cosmetic ingredient database, http://ec.europa.eu/consumers/cosmetics/cosing/index.cfm?fuseaction= search.details&id=56403. (Erişim Tarihi: 15.12.2020).
5. Anonymous, 2019. Humates, http://www.teravita.com/Humates/Chapter9.htm. (Erişim Tarihi: 15.12.2020).
6. Anonymous, 2018. Some humifulvate science, https://cdn.shopify.com/s/files/1/0758/8575/files/Some_Humifulvate_.pdf? 6298119927275493704. (Erişim Tarihi: 28.07.2020).
7. Ansorg R., Rochus W. Studies on the antimicrobial effect of natural and synthetic humic acids. Arzneimittel-Forschung 1978; 28(12): 2195-2198.
8. Banaszkiewick W., Drobnik M. The influence of natural peat and isolated humic acid solution on certain indices of metabolism and of acid-base equilibrium in experimental animals. Roczniki Panstwowego Zakladu Higieny 1994; 45(4): 353-360.

9. Brzozowski T., Dembinski A., Konturek S. Influence of tolpa peat prepation on gastroprotection and on gastric and duodenal ulcers. Acta Poloniae Pharmaceutica 1994; 51(1): 103-107.
10. Cushman M., Wang P., Chang SH., Wild C., De Clercq E., Schols D., Goldman ME., Bowen JA. Preparation and anti-HIV activities of aurintricarboxylic acid fractions and analogues: direct correlation of antiviral potency with molecular weight. Journal of Medicinal Chemistry 1991; 34(1): 329-337.
11. Çalışır M., Akpınar A., Dizman M., Tutar A. Oral aftöz ülserler üzerinde hümik asidin etkileri: bir vaka raporu. Sakarya Üniversitesi Fen Edebiyat Fakültesi Dergisi 2012; 1: 119-130.
12. Çelik C. Zeytin karasuyundan hümik asit (Ha) ve fulvik asitlerin (Fa) eldesi ve karakterizasyonu. Çukurova Üniversitesi Fen Bilimleri Enstitüsü Yüksek Lisans Tezi Adana, Türkiye, 2010.
13. Çetin N., Çetin E., Kocaoğlu Güçlü B. Yumurta tavuklarında rasyona ilave edilen humat ve organik asitlerin bazı hematolojik parametreler üzerine etkisi. Ankara Üniversitesi Veterinerlik Fakültesi Dergisi 2006; 53: 165-168.
14. Dabovich LA., Hulbert L., Rudine AS., Kim F., Mcglone JJ. Evaluation of nutriceutical effects on pig immunity: effects of promox. Southern Section ASAS Meeting, Pork Industry Institute, Department of Animal and Food Science, Texastech University, Lubbock 2003.
15. Demir Aktaş A. Humik asidin insan serviks kanseri üzerine antikanserojenik etkilerinin araştırılması. Marmara Üniversitesi Sağlık Bilimleri Enstitüsü Yüksek Lisans Tezi, İstanbul, Türkiye, 2019.
16. Dizman M., Tutar A., Karaman MR., Turan M., Horuz A. Humik maddelerin ilaç olarak kullanımı ve insan sağlığına etkileri. Sakarya Üniversitesi Fen Edebiyat Fakültesi Dergisi 2012; 1: 25-33.
17. Dizman M., Tutar A. A novel polymer blend based on sodium humate/PVP/PEG. Functions of natural organic matter in changing environment, Springer 2012; 323-328.
18. Fuchs V., Kühnert M., Golbs S., Dedek W. The enteral absorbtion of iron (II) from humic acid-iron complexes in suckling piglets using radiolabelled iron (59Fe). Deutsche Tierarztliche Wochenschrift 1990; 97(5): 208-209.
19. Gadzhieva NZ., Tsoi EP., Turovskaia SI., Ammosova IM. The antibacterial activity of a humic preparation made from the therapeutic peat mud of the dzalal abad deposit in Kirghizia. Nauchnye Doklady Vysshei Shkoly Biologicheskie Nauki 1991; 10: 109-113.
20. Ghabbour EA., Davies G. Humic substances: structures, models and functions. England: Royal Society of Chemistry; 2001.
21. Ghabbour EA., Khairy AH., Cheney DP., Gross V., Davies G., Gilbert TR., Zhang X. Isolation of. humic acid from the brown algapilayella littoralis. Journal of Applied Phycology 1994; 6(5-6): 459-468.
22. Golbs S., Fuchs V., Kühnert M., Polo C. Prenatal toxicological testing of humic acids on laboratory rats. Archiv Fur Experimentelle Veterinarmedizin 1982; 36(2): 179-185.
23. Gonzalez S., Fernandez-Lorente M., Gilaberte-Calzada Y. The latest on skin photoprotection. Clinics in Dermatology 2008; 26(6): 614-626.
24. Hedges IJ., Oades JM. Comparative organic geochemistries of soils and marine sediments. Organic Geochemistry 1997; 27(7-8): 319-361.
25. Hils J., May A., Sperber M., Klöcking R., Helbig B., Sprössig M. Inhibition of several strains of influenza virus type a and b by phenolic polymers. Biomedica Biochimica Acta 1986; 45(9): 1173-1179.
26. Inglot AD., Zielinksa-Jenczylik J., Piasecki E. Tołpa torf preparation (TTP) induces interferon and tumor necrosis factor production in human peripheral blood leukocytes. Archivum Immunologiae et Therapiae Experimentalis 1993; 41(1): 73-80.
27. Islam KMS., Schuhmacher A., Gropp JM. Humic acid substances in animal agriculture. Pakistan Journal of Nutrition 2005; 4(3): 126-134.
28. Iubıtskala NS., Ivanov EM. Sodium humate in the treatment of osteoarthrosis patients. Voprosy Kurortologii, Fizioterapii, İ Lechebnoi Fizicheskoi Kultury 1999; 5: 22-24.
29. İskender H. Humatın Kurşun zehirlenmesinde şelatör etkisi. Atatürk Üniversitesi Sağlık Bilimleri Enstitüsü Doktora Tezi, Erzurum, Türkiye, 2012.
30. Jankowski A., Nienartowich B., Polanska B., Levandowicz-Uszynska A. A randomised, double-blind study on the efficacy of tołpa torf preparation (TTP) in the treatment of recurrent respiratory tract infections. Archivum Immunologiae et Therapiae Experimentalis 1993; 41(1): 95-97.
31. Joone GK., Dekker J., Van Rensburg CE. Investigation of the immunostimulatory properties of oxihumate. Zeitschrift Für Naturforschung C 2003; 58(3-4): 263-267.
32. Juszkiewicz T., Minta M., Wlodarczyk B., Biernacki B., Zmudzki J. Studies on The embryotoxic and teratogenic effects of tołpa peat preparation. Acta Poloniae Pharmaceutica 1993; 50(4-5): 383-388.
33. Khairy AH., Ziechmann W. Die veränderung von huminsäuren in alkalischer lösung. Zeitschrift für Pflanzenernährung und Bodenkunde 1981; 144(4): 407-422.
34. Klöcking HP. Influence of natural humic acids and synthetic phenolic polymers on haemostasis. Archives of Toxicology 1991; 14: 166-169.
35. Klöcking HP., Junek R., Schubert R., Klöcking R. In vitro methods for testing the biocompatibility of humic substances. Toxicology Letters 2009; 189: 88.
36. Klöcking R., Sprössig M. Antiviral properties of humic acids. Experientia 1972; 28: 607-608.
37. Klöcking R., Thiel KD., Wutzler P., Helbig B., Drabke P. Antiviral activity of phenolic polymers against type 1 herpesvirus hominis. Pharmazie 1978; 33(8): 539.
38. Klöcking R., Helbig B., Schötz G., Schacke M., Wutzler P. Anti-HSV-1 activity of synthetic humic acid-like polymers derived from p-diphenolic starting compounds. Antiviral Chemistry and Chemotherapy 2002; 13(4): 241-249.
39. Klöcking R., Sprössig M., Witzler P., Thiel KD., Helbig B. Antiviral wirksame huminsaureahnliche polymere. Zeitschrift Für Physiotherapie 1983; 35(2): 95-101.
40. Koziorowska J., Anuszewska E. Evaluation of potential carcinogenic properties of tołpa peat preparation in vitro. Acta Poloniae Pharmaceutica 1994; 51(1): 101-102.
41. Köksal BH. Kanatlı yemlerinde humatın kullanımı. Veteriner Tavukçuluk Derneği 2008; 6(4): 6-12.
42. Köksal BH. Humat ile bitki ekstraktlarının broyler ve yumurtacı tavuklarda kullanılması. Ankara Üniversitesi Sağlık Bilimleri Enstitüsü Doktora Tezi, Ankara, Türkiye, 2009.
43. Kreutz B., Schlikekewey W. Effects of implanted bovine calcium hydroxyapatite with humate. Archives of Orthopaedic and Trauma Surgery 1992; 111: 259-264.
44. Kuehnert M., Fuchs V., Golbs S. Chemical characterization and pharmacologic and toxicologic peculiarities of humic acid. Archiv fur Experimentelle Veterinarmedizin 1982; 36(2): 169-177.
45. Kutluca M. Hümik asitlerin metal tutma ve ligand değiştirme özelliklerinin incelenmesi. Selçuk Üniversitesi Fen Bilimleri Enstitüsü Yüksek Lisans Tezi, Konya, Türkiye, 2007.
46. Kühnert VM., Bartels KP., Kröll S., Lange N. Huminsäurehaltige tierarzneimittel in therapie and prophylaxe bei gastrointestinalen erkrankungen von hund und katze. Monatshefte fur Veterinarmedizin 1991; 46: 4-8.
47. Laub RJ. Process for preparing synthetic soil-extract materials and medicament based thereon. US Patent 5 945 446, 1999.
48. Laub RJ. Laub developing humates with anti-HIV, HSV, HPV and other antiviral activity. Biotechnology Information Institute, Antiviral Drug and Vaccine Development Information 2000; 13(2): 6.
49. Lotosh TD. Experimental bases and prospects for the use of humic acid preparations from peat in medicine and agricultural production. Nauchnye Doklady Vysshei Shkoly Biologicheskie Nauki 1991; 10: 99-103.
50. Madej JA., Kuryszko J., Garbuliski T. The influence of long-term administration of tolpa peat preparation on immune reactivity in mice. I. morphological changes in the thymus. Acta Poloniae Pharmaceutica 1993; 50(4-5): 397-404.
51. Maslinski C., Fogel WA., Andrzejewski W. An examination of humate stimulated liver functions. Acta Poloniae Pharmaceutica 1993; 50(4-5): 413-416.
52. Mentel R., Helbig B., Klöcking R., Döhner L., Sprössig M. Effectiveness of phenol body polymers against influenza virus a/krasnodar/101/59/H2N2. Biomedica Biochimica Acta 1983; 42(10): 1353-1356.
53. Oyüryüz Şenel Z., Gürel A. Hümik Maddelerin Kullanım Alanları ve Sektörde Girişimcilik. Sakarya Üniversitesi Fen Edebiyat Fakültesi Dergisi 2012; 1: 345-350.
54. Pukhova GG., Druzhina NA., Stepchenko LM., Chebotarev EE. Effect of sodium humate on animals irradiated with lethal doses. Radiobiologiia 1987; 27(5): 650-653.
55. Reichrath J., Lehmann B., Carlberg C., Varani J., Zouoilis CC. Vitamins as hormones. Hormone and Metabolic Research 2007; 39(2): 71-84.
56. Ridwan FNI., Molnaru S., Rochus W. Untersuchungen zur huminsäurenabsorption. Naturwissen-Schaften 1978; 65(10): 539.
57. Riede UN., Zeck-Kapp G., Freudenberg N., Keller HU., Seubert B. Humate-induced activation of human granulocytes. Virchows Archiv B Cell Pathology 1991; 60(1): 27-34.
58. Riede UN., Jonas I., Kirn B., Usener UH., Kreutz W., Schlickewey W. Collagen stabilization induced by natural humic substances. Archives of Orthopaedic and Trauma Surgery 1992; 111(5): 259-264.
59. Sato T., Ose Y., Nagase H. Desmutagenic effect of humic acid. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 1986; 162(2): 173-178.
60. Sato T., Ose Y., Nagase H., Hayase K. Adsorption of mutagens by humic acid. Science of the Total Environment 1987a; 62(4): 305-310.
61. Sato T., Ose Y., Nagase H., Hayase K. Mechanism of the desmutagenic effect of humic acid. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 1987b; 176(2): 199-204.
62. Schewe C., Klöcking R., Helbig B., Schewe T. Lipoxygenase-inhibitory action of antiviral polymeric oxidation products of polyphenols. Biomedica Biochimica Acta 1991; 50(3): 299-305.
63. Schneider J., Weis R., Manner C., Kary B., Werner A., Seubert BJ., Riede UN. Inhibition of HIV-1 in cell culture by synthetic humate analogues derived from hydroquinone: mechanism of inhibition. Virology 1996; 218(2): 389-395.
64. Schnitzer M., Khan SU. Humic substances in the environment, Marcel Dekker, Inc., New York; 1972.
65. Senesi N., Miano TM. Humic substances in the global environment and implications in human health, Amsterdam-Netherlands; 1992.
66. Skinner JJ., Izat AL., Waldroup PW. Research note: fumaric acids enhances performance of broiler chickens. Poultry Science 1991; 70(6): 1444-1447.
67. Skliar TV., Krysenko AV., Gavriliuk VG., Vinnikov AI. A Comparison of the developmental characteristics of neisseria gonorrhoeae and staphylococcus aureus cultures on nutrient media of different compositions. Mikrobiolohichnyi Zhurnal 1998; 60(1): 25-30.
68. Sparks DL. Environmental soil chemistry. Elsevier Science: California-America; 2003
69. Stackhouse RA, Benson WH. The effect of humic acid on the toxicity and bioavailability of trivalent chromium. Ecotoxicology and Environmental Safety 2003; 17 (1): 105-111.
70. Stevenson F. Humus chemistry: genesis, composition, reactions. Wiley: New York-America; 1982.
71. Sydow G., Wunderlich V., Klöcking R., Helbig B. The effect of phenolic polymers on retroviruses. Pharmazie 1986; 41(12):, 865-868.
72. Taugner B. Tierexperimentelle untersuchungen über ein natriumhuminatsalicylsäure-bad. Arznei-Forschung Drug Research 1963; 13: 329-333.
73. Terratol LLC. Effects of humic acid on animals and humans. Literature Review and Current Research 2012; 1-12.
74. Thiel KD., Eichhorn U., Schweizer H., Klöcking R. Morphological and biochemical criteria for evaluating cytotoxic effects of antiviral substances. Archives of Toxicology 1980; 4: 428-430.
75. Thiel KD., Heibig B., Klöching R., Vutzier P., Sprössig M., Schweizer H. Comparison of the in vitro activities of ammonium humate and of enzymically oxidized chlorogenic and caffeic acids against type 1 and type 2 human herpes virus. Pharmazie 1981; 36(1): 50-53.
76. Thiel KD., Klöcking R., Schweizer H., Sprössig M. In vitro studies of the antiviral activity of ammonium humate against herpes simplex virus type 1 and type 2. Medizinische Mikrobiologie und Parasitologie 1977; 239(3): 304-321.
77. Thiel KD., Wutzler P., Helbig B., Klöcking R., Sprössig M., Schweizer H. Antiviral effect of enzymatically and nonenzymatically oxidized caffeic and hydrocaffeic acids against herpesvirus hominis type 1 and type 2 in vitro. Pharmazie 1984; 39(11): 781-782.
78. Thomson JL., Hinton M. Antibacterial activity on formic and propionic acids in the diet of hens on salmonellos in the crop. British Poultry Science 1997; 38(1): 59-65.
79. Tipping E. Cation binding by humic substances. Cambridge University Press: Cambridge-England; 2002.
80. Trckova M., Matlova L., Hudcova H., Faldyna M., Zraly Z., Dvorska L., Beran V., Pavlik I. Peat as a feed supplement for animals: a review. Veterinarni Medicina 2005; 50(8): 361-377.
81. Visser SA. Some biological effects of humic acids in the rat. Acta Biologica et Medica Germanica 1973; 31(4): 569-581.
82. Visser SA. Effect of humic substances on mitochondrial respiration and oxidative phosphorylation. Science of The Total Environment 1987; 62(4): 347-354.
83. Wasiak J., Cleland H., Campbell F. Dressings for superficial and partial thickness burns. Cochrane Database of Systematic Reviews Intervention 2008; 4: 1-44.
84. Wohlrab W., Helbig B., Klöcking R., Sprössig M. Penetration kinetics of potential virustatics into the human skin. Pharmazie 1984; 39(8): 562-564.
85. Wollina U. Peat: a natural source for dermatocosmetics and dermatotherapeutics. Journal of Cutaneous and Aesthetic Surgery 2009; 2(1): 17–20.
86. Woyton J., Gabrys M., Bielanow T., Zimmer M., Sokalski J., Geneja R., Zborowski M. A Comparison of efficacy of tołpa torf preparation (TTP) in the treatment of cervicitis with or without surgery. Archivum Immunologiae et Therapiae Experimentalis 1993; 41(1): 99-103.
87. Yamada E., Ozaki T. Kimura M. Determination and behavior of humic substances as precursors of trihalomethane in environmental water. Analytical Sciences 1998; 14(2): 327-332.
88. Yamamoto M., Nishida A., Otsuka K., Komai T., Fukushima M. Evaluation of the binding of iron(II) to humic substances derived from a compost sample by a colorimetric method using ferrozine. Bioresource Technology 2010; 101(12): 4456-4460.
89. Yılmaz RF., Dizman M., Tutar A. Investigation of the effects of humic substances on skin diseases. 4th International Turkish Conference on Humic Substances (ITCHS, 2019), October 25-29, 2019, sayfa no: 2, Sakarya.
90. Zralý Z., Písaříková B., Trčková M., Navrátilová M. Effect of humic acids on lead accumulation in chicken organs and muscles. Acta Veterinaria Brno 2008; 77(3): 439-445.