yok
T-cell lymphoma (PTHL) is a rare and aggressive subtype of non-Hodgkin lymphomas. The prognosis is poor in all subgroups except for ALK-positive anaplastic large cell lymphoma. In recent years, the use of targeted therapies in patients with relapse-refractory (RR) disease, as well as salvage chemotherapy regimens, has become increasingly common. Among these, belinostat, a histone deacetylase (HDAC) inhibitor has been used in patients with RR PTHL since July 2019 in Turkey.In this study, it was aimed to evaluate the outcome of patients who were known to be treated with belinostat in Turkey with the diagnosis of RR PTHL. Patients who were diagnosed with RR PTHL and known to be treated with belinostat in Turkey since the date of approval for its use were included in the study. Demographic, pathological and clinical features and objective response rates were recorded. The data obtained were evaluated in the light of the literature. Ten patients from a total of 5 centers were evaluated. The follow-up period from diagnosis was 38 months. The most common pathological subtype was ALK-negative PTHL (40%). Complete response in 2 patients, partial response in 3 patients and progression in 4 patients were observed with belinostat, and the response status could not be evaluated in 1 patient. Two patients who progressed on belinostat treatment died. Time from belinostat to death in these patients was 1 and 2 months, respectively. Grade 3 hematological side effects (neutropenia) were observed in one patient. Our study is important in terms of the fact that it is the first study in Turkey to present national multicenter real-life data regarding belinostat.
Primary Language | Turkish |
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Subjects | Health Care Administration |
Journal Section | ORİJİNAL MAKALE |
Authors | |
Publication Date | July 19, 2022 |
Published in Issue | Year 2022 |