Outcome of Belinostat in Patients with Peripheral T Cell Lymphoma, Multicenter Real-Life Data, Turkey

Öz

T-cell lymphoma (PTHL) is a rare and aggressive subtype of non-Hodgkin lymphomas. The prognosis is poor in all subgroups except for ALK-positive anaplastic large cell lymphoma. In recent years, the use of targeted therapies in patients with relapse-refractory (RR) disease, as well as salvage chemotherapy regimens, has become increasingly common. Among these, belinostat, a histone deacetylase (HDAC) inhibitor has been used in patients with RR PTHL since July 2019 in Turkey.In this study, it was aimed to evaluate the outcome of patients who were known to be treated with belinostat in Turkey with the diagnosis of RR PTHL. Patients who were diagnosed with RR PTHL and known to be treated with belinostat in Turkey since the date of approval for its use were included in the study. Demographic, pathological and clinical features and objective response rates were recorded. The data obtained were evaluated in the light of the literature. Ten patients from a total of 5 centers were evaluated. The follow-up period from diagnosis was 38 months. The most common pathological subtype was ALK-negative PTHL (40%). Complete response in 2 patients, partial response in 3 patients and progression in 4 patients were observed with belinostat, and the response status could not be evaluated in 1 patient. Two patients who progressed on belinostat treatment died. Time from belinostat to death in these patients was 1 and 2 months, respectively. Grade 3 hematological side effects (neutropenia) were observed in one patient. Our study is important in terms of the fact that it is the first study in Turkey to present national multicenter real-life data regarding belinostat.

Anahtar Kelimeler

• Peripheral T cell lymphoma
• Peripheral T cell lymphoma
• Belinostat
• non hodgkin

Periferik T cell Lenfomalı Hastalarda Belinostat Deneyimi; Çok Merkezli Gerçek Yaşam Verisi, Türkiye

Öz

Periferik T hücreli lenfomalar (PTHL) non hodgkin lenfomaların oldukça agresif nadir bir alt türüdür. ALK-pozitif anaplastik büyük hücreli lenfoma dışındaki tüm alt gruplarda prognoz kötüdür. Son yıllarda kurtarma rejimlerinin yanı sıra relaps refrakter (RR) hastalarda hedef tedavilerin kullanımı giderek yaygınlaşmaktadır. Bunlardan belinostat; histon deasetilaz (HDAC) inhibitörü olup Türkiye’de Temmuz 2019 dan itibaren RR PTHL hastalarda kullanıma girmiştir. Bu çalışmada şimdiye kadar RR PTHL tanısı ile ülkemizde belinostat tedavisi alan hastaların sonuçlarının değerlendirilmesi planlandı. Kullanıma girdiği tarihten itibaren RR PTHL ile tanısı olan ve Türkiyede belinostat tedavisi alan ve erişilebilen tüm hastalar çalışmaya dahil edildi. Demografik, patolojik ve klinik özellikleri, objektif yanıt oranları kaydedildi. Elde edilen veriler literatür eşliğinde değerlendirildi. Toplam 5 merkezden 10 hasta değerlendirildi. Tanıdan itibaren takip süresi 38 ay idi. En sık görülen patolojik alt tip ALK negatif PTHL (%40) idi. Belinostat tedavisi ile 2 hastada tam yanıt, 3 hastada parsiyel yanıt, 4 hastada da progresyon izlendi, 1 hastada ise durum değerlendirilmesi yapılamadı. Takiplerinde progrese olan 2 hasta eksitus oldu. Bu hastalarda belinostattan ölüme kadar geçen süre 1 ve 2 ay idi. Bir hastada grade 3 hematolojik yan etki (nötropeni) görüldü. Çalışmamız belinostat ile ilgili olarak ülkemizde ulusal çok merkezli gerçek yaşam verilerini sunan ilk çalışma olması bakımından önem taşımaktadır

Anahtar Kelimeler

• Periferik T cell lenfoma
• Belinostat
• non hodgki n lenfoma

Kaynakça

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