Behçet hastalığı nötrofil-lenfosit oranı vasküler tutulum hastalık aktivitesi
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Behcet disease is a systemic vasculitis characterized by recurrent oral and genital ulceration, uveitis and cutaneous lesions. Neutrophil-lymphocyte ratio (NLR) is a new marker investigated for indicating inflammation. Our aim in this study was to evaluate NLR in Behcet patients with vascular and mucocutaneus involvement and to compare with healthy controls.This study included 20 Behcet patients with thrombosis (Group 1), 20 Behcet patients with mucocutaneus involvement (Group 2) and 20 healthy subjects (Group 3). The neutrophil and lymphocyte counts of the patients in hemograms were used to calculate NLR.Age and sex distribution did not show any difference among groups (p: 0.416and p:0.442, respectively). Hemoglobin levels was lowest and leucocyte and absolute neutrophil counts were highest in Group 1 (p:0.045,p:0.033 ve p:0.003, respectively). NLR was higher in Group 1than Group 2 and 3 (p:0.016; multi analysis results: 1 vs 2; p:0.009, 1 vs 3; p:0.018, 1 vs 3; p:0.807). NLR and disease activity and severity did not show correlation in Group 1 (for activity: r:-0.212, p: 0.370 and for severity r: -0.223, p: 0.344, respectively). The correlation between NLR and C-RP was only significant in Group 1 (r: 0.634, p: 0.03)but ESR did not show correlation in any group (p>0.05).In conclusion, NLR was higher in Behcet patients with thrombosis than Behcet patients with mucocutaneus involvement and control group. NLR may be useful in situations without any specific marker to determine increased inflammation or disease activity such as Behcet disease.
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Birincil Dil | Türkçe |
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Konular | Sağlık Kurumları Yönetimi |
Bölüm | ORİJİNAL MAKALELER / ORIGINAL ARTICLES |
Yazarlar | |
Proje Numarası | - |
Yayımlanma Tarihi | 20 Ocak 2021 |
Yayımlandığı Sayı | Yıl 2021 |