Notch Sinyal Yolağı ve Karsinogenez / Notch Signaling Pathway and Carcinogenesis

Year 2017, Volume: 39 Issue: 1, 109 - 116, 15.03.2017

Emine Yağcı Hasan Veysi Güneş

https://doi.org/10.20515/otd.287890

Abstract

Notch
sinyal yolağı, gelişim döneminde hücre kaderinin belirlenmesinde rol oynayan
bir mekanizmadır. Notch reseptörü boyunca komşu hücreler arasındaki sinyal
alışverişi artar. Notch aktivitesi organ oluşumu ve morfogenezde rol oynayarak
farklılaşma, çoğalma ve apoptozu etkiler. Son çalışmalar Notch sinyalinin hücre
farklılaşması ve proliferasyonu ile apoptotik olaylarda rol oynadığını kanıtlanmıştır.
Ayrıca kanserli hücrelerde Notch aktivasyonunun anormal hücre çoğalmasına neden
olduğu görülmüştür. Notch ile hücre çoğalması arasında önemli bir bağlantı
olduğu birçok çalışmada gösterilmiştir. Bu derlemede Notch sinyal yolağı
elementleri, aktivasyonu ve kanseri hangi mekanizmalarla etkilediği ele
alınmaktadır.

Keywords

Notch sinyal yolağı, Kanser, Apoptoz

References

• Acar, M., Jafar-Nejad, H., Takeuchi, H., Rajan, A., Ibrani, D., Rana, N. A., Bellen, H. J. (2008). Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell, 132(2), 247-258.
• Arasada RR, Amann JM, Rahman MA, Huppert SS, Carbone DP (2014) EGFR blockade enriches for lung cancer stemlike cells through Notch3-dependent signaling. Cancer Res 74(19):5572–5584.
• Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999). Notch signaling: cell fate control and signal integration in development. Science, 284(5415), 770-776.
• Basseres, D., & Baldwin, A. (2006). Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression. Oncogene, 25(51), 6817-6830.
• Beg, A. A., William, C. S., Bronson, R. T., Ghosh, S., & Baltimore, D. (1995). Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB.
• Beverly, L. J., Felsher, D. W., & Capobianco, A. J. (2005). Suppression of p53 by Notch in lymphomagenesis: implications for initiation and regression. Cancer research, 65(16), 7159-7168.
• Boggs, K., Henderson, B., & Reisman, D. (2009). RBP‐Jκ binds to and represses transcription of the p53 tumor suppressor gene. Cell biology international, 33(3), 318-324.
• Brzozowa-Zasada, M., Piecuch, A., Dittfeld, A., Mielańczyk, Ł., Michalski, M., Wyrobiec, G., ... & Wojnicz, R. (2016). Notch signalling pathway as an oncogenic factor involved in cancer development. Contemp Oncol (Pozn), 20(4), 267-272.
• Cheng, P., Zlobin, A., Volgina, V., Gottipati, S., Osborne, B., Simel, E. J., Gabrilovich, D. I. (2001). Notch-1 regulates NF-κB activity in hemopoietic progenitor cells. The Journal of Immunology, 167(8), 4458-4467.
• Dallman, M. J., Smith, E., Benson, R. A., & Lamb, J. R. (2005). Notch: control of lymphocyte differentiation in the periphery. Current opinion in immunology, 17(3), 259-266.
• Dang, T. P. (2012). Notch, apoptosis and cancer Notch Signaling in Embryology and Cancer (pp. 199-209): Springer.
• Haruki N, Kawaguchi KS, Eichenberger S, Massion PP, Olson S, Gonzalez A, Carbone DP, Dang TP (2005) Dominant-negative Notch3 receptor inhibits mitogen activated protein kinase pathway and the growth of human lung cancers. Cancer Res 65(9):3555–3561.
• Hassan KA, Wang L, Korkaya H, Chen G, Maillard I, Beer DG, Kalemkerian GP, Wicha MS (2013) Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. Clin Cancer Res 19(8):1972–1980.
• Hassan WA, Yoshida R, Kudoh S, Hasegawa K, Niimori-Kita K, Ito T (2014) Notch1 controls cell invasion and metastasis in small cell lung carcinoma cell lines. Lung Cancer 86(3):304–310.
• Hassan, Wael Abdo, et al. "Evaluation of role of Notch3 signaling pathway in human lung cancer cells." Journal of cancer research and clinical oncology 142.5 (2016): 981-993.
• Kerr, J. F., Wyllie, A. H., & Currie, A. R. (1972). Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. British journal of cancer, 26(4), 239.
• Kidd, S., Kelley, M. R., & Young, M. W. (1986). Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors. Molecular and cellular biology, 6(9), 3094-3108.
• Kiyohara, C., & Ohno, Y. (2010). Sex differences in lung cancer susceptibility: a review. Gender medicine, 7(5), 381-401.
• Konishi J, Kawaguchi KS, Vo H, Haruki N, Gonzalez A, Carbone DP, Dang TP (2007) Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers. Cancer Res 67(17):8051–8057.
• Kopan, R. (2002). Notch: a membrane-bound transcription factor. Journal of cell science, 115(6), 1095-1097.
• Kramer, H. (2000). RIPping notch apart: a new role for endocytosis in signal transduction? Science Signaling, 2000(29), pg1.
• Krauss, G. (2006). Biochemistry of signal transduction and regulation: John Wiley & Sons.
• Ladanyi, M., Cha, C., Lewis, R., Jhanwar, S. C., Huvos, A. G., & Healey, J. H. (1993). MDM2 gene amplification in metastatic osteosarcoma. Cancer research, 53(1), 16-18.
• Lee S, Jung C, Ko Y, Choi J, Lee K, Kang C (2008) Expression of Notch 1 and 3 is related to inhibition of lymph node metastasis and progression in non-small lung carcinoma. Basic Appl Pathol 1(2):93–97.
• Li GG, Li L, Li C, et al. Influence of up-regulation of Notch ligand DLL4 on biological behaviors of human gastric cancer cells. World J Gastroenterol 2013; 19: 4486-94.
• Liu L, Chen X, Wang Y, Qu Z, Lu Q, Zhao J, Yan X, Zhang H, Zhou Y (2014) Notch3 is important for TGF-β-induced epithelial-mesenchymal transition in non-small cell lung cancer bone metastasis by regulating ZEB-1. Cancer Gene Ther 21(9):364–372.
• Miele, L. (2006). Notch signaling. Clinical Cancer Research, 12(4), 1074-1079.
• Mullendore ME, Koorstra JB, Li YM, Offerhaus GJ, Fan X, Hender- son CM, et al. Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer. Clin Cancer Res 2009; 15: 2291-301.
• Oakley, F., Mann, J., Ruddell, R. G., Pickford, J., Weinmaster, G., & Mann, D. A. (2003). Basal expression of IκBα is controlled by the mammalian transcriptional repressor RBP-J (CBF1) and its activator Notch1. Journal of Biological Chemistry, 278(27), 24359-24370.
• Ohishi, K., Varnum-Finney, B., Flowers, D., Anasetti, C., Myerson, D., & Bernstein, I. D. (2000). Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1. Blood, 95(9), 2847-2854.
• Pazarbaşı, A., Kasap, H., & KASAP, M. (2011). Kanser Yolakları. Arşiv, 20, 187-229.
• Roy M, Pear WS, Aster JC (2007) The multifaceted role of Notch in cancer. Curr Opin Genet Dev 17(1):52–59.
• Sanchez-Cespedes, M., Reed, A. L., Buta, M., Wu, L., Westra, W. H., Herman, J. G., Sidransky, D. (1999). Inactivation of the INK4A/ARF locus frequently coexists with TP53 mutations in non-small cell lung cancer. Oncogene, 18(43), 5843-5849.
• Schulz, W. A. (2005). Molecular biology of human cancers (Vol. 464): Springer.
• Vousden, K. H., & Lane, D. P. (2007). p53 in health and disease. Nature reviews Molecular cell biology, 8(4), 275-283.
• Wael H, Yoshida R, Kudoh S, Hasegawa K, Niimori-Kita K, Ito T (2014) Notch1 signaling controls cell proliferation, apoptosis and differentiation in lung carcinoma. Lung Cancer 85(2):131–140.
• Wharton, K. A., Johansen, K. M., Xu, T., & Artavanis-Tsakonas, S. (1985). Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell, 43(3), 567-581.
• White, D. W., Roy, A., & Gilmore, T. D. (1995). The v-Rel oncoprotein blocks apoptosis and proteolysis of I kappa B-alpha in transformed chicken spleen cells. Oncogene, 10(5), 857-868.