Cytokines

Year 2018, , 36 - 45, 31.03.2018

Mehmet Akdoğan , Mustafa Yöntem

https://doi.org/10.26453/otjhs.350321

Cited By: 6

Abstract

Cytokines are a broad and loose category of small
proteins (~5–20 kDa) that are important in cell signaling. They are released by
cells and affect the behavior of other cells, and sometimes the releasing cell
itself. There are many types of Cytokines, including chemokines, interferons,
interleukins, lymphokines, tumour necrosis factor but generally not hormones or
growth factors (despite some terminologic overlap). All those types of
cytokines are produced by a broad range of cells, including immune cells like
macrophages, B lymphocytes, T lymphocytes and mast cells, as well as
endothelial cells, fibroblasts, and various stromal cells; a given cytokine may
be produced by more than one type of cell.

Keywords

cytokines, chemokines, interleukins, types of cytokines

Sitokinler

Abstract

Sitokinler,
hücre işaretlemesinde önem taşıyan geniş ve gevşek küçük protein kategorileri
(~ 5-20 kDa)’dir. Hücreler tarafından serbest bırakılır ve diğer hücrelerin
davranışını etkiler ve bazen hücrenin kendisini serbest bırakır. Kemokinler,
interferonlar, interlökinler, lenfokinler, tümör nekroz faktörü, ancak
genellikle hormonlar veya büyüme faktörleri (bazı terminolojik örtüşmelere
rağmen) olmayan pek çok Sitokin türü vardır. Tüm bu tip sitokinler,
makrofajlar, B lenfositleri, T lenfositleri ve mast hücreleri gibi bağışıklık
hücrelerinin yanı sıra endotel hücreleri, fibroblastlar ve çeşitli stromal
hücreler de dahil olmak üzere geniş bir hücre yelpazesi tarafından üretilir;
Verilen bir sitokin birden fazla hücre türü tarafından üretilebilir.

Keywords

stokinler, kemokinler, interlökinler, stokin türleri

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