Diyabetik Nöropatisi Olan Kişilerde Monosit/HDL Kolesterol Oranı ile Kardiyovasküler Risk Arasındaki İlişki

Year 2019, Volume: 4 Issue: 4, 526 - 538, 31.12.2019

Halime Hanım Pençe , Hanife Şerife Aktaş

https://doi.org/10.26453/otjhs.620725

Cited By: 4

Abstract

Bu çalışmada diyabetin mikrovasküler komplikasyonlarından olan diyabetik
nöropatisi olan hastalarda monosit/HDL kolesterol oranı (MHR)’nin
kardiyovasküler risk belirteci olup olamayacağının araştırılması amaçlanmıştır.
Dahiliye polikliniğimizdeki Ocak 2018- Eylül 2018 tarihleri arasındaki
hastalardan 30 diyabetik nöropatisi (DN) olan diabetes mellitus (DM) hastası, 29
DN olmayan DM hastası ve aynı yaş ve cinsiyette 30 DM olmayan sağlıklı
retrospektif olarak çalışmaya alındı. Yaş, cinsiyet, vücut kitle indeksi (BMI),
sigara, DM süresi, hipertansiyon, hemogramdaki monosit sayısı, glikozile
hemoglobin A1c (HbA1c), total kolesterol, düşük yoğunluklu lipoprotein LDL
kolesterol (LDL-K), yüksek yoğunluklu lipoprotein HDL kolesterol (HDL-K),
trigliserid (TG) ve mikroalbuminüri, MHR, Framingham Kardiyovasküler Risk
Skorlamasına (FCR) göre olan kardiyovasküler risk oranı incelendi. DN ile DN-olmayan diyabetikler arasında
DM süresi açısından fark olduğu görüldü (p<0.05). DN grubun total kolesterol
düzeyleri DN-olmayan gruptan (p<0.05) ve kontrol grubundan (p<0.01) yüksek
bulundu. Yine DN grubun HbA1c düzeyleri de daha yüksek bulundu (p<0.001). Kontrol
grubunun FCR skorları DN ve DN olmayan gruptan anlamlı şekilde düşüktü (p<0001).
Grupların MHR’si arasında fark bulunmadı. Tüm hastalarda MHR ile HbA1c, FCR skorları
arasında korelasyon bulundu (Spearman’s rho p <0.05). Bu çalışmada diyabetik
nöropatisi olan hastalarda MHR’nin kardiyovasküler risk belirteci olabileceği
sonucuna ulaşılamamıştır. Ancak tüm hastalarda MHR ile kardiyovasküler risk
arasında bir korelasyon görülmüştür. Bu konuda daha geniş serilerde çalışma
yapılmasına ihtiyaç vardır.

Keywords

Diyabetik nöropati, kardiyovasküler risk, monosit/HDL-K

The Relationship Between Monocyte / HDL-Cholesterol Ratio and Cardiovascular Risk in Diabetic Neuropathia

Abstract

The aim of this study was to investigate
whether monocyte/HDL cholesterol ratio (MHR) could be a marker of
cardiovascular risk in patients with diabetic neuropathy which is one of the
microvascular complication of diabetes.  30
patients with diabetic neuropathy (DN), 30 patients with non-DN- diabetes
mellitus (DM), 30 healthy individuals with non-DM same age and sex in our
internal medicine clinic between January 2018- September 2018 were
retrospectively studied. Age, gender, body mass index (BMI), smoking, hypertension,
the number of monocytes, HbA1c, total cholesterol, low density lipoprotein
LDL-cholesterol (LDL-C), high density lipoprotein HDL-cholesterol (HDL-C),
triglyceride, microalbuminuria, MHR, Framingham Cardiovascular Risk Scoring
(FCR) were investigated. There was
a significant difference in the duration of DM between non-DN and diabetic
patients (p <0.05). Total cholesterol levels of DN group were higher than
non-DN group (p <0.05) and control group (p <0.01). The FCR scores of the
control group were significantly lower than the DN and non-DN groups (p
<0001).There was no difference between MHR and HbA1c and FCR scores in all
patients (Spearman’s rho p <0.05). In
this study, we could not conclude that MHR can be a predictor of cardiovascular
risk in patients with diabetic neuropathy. However, there was a correlation between cardiovascular risk and MHR in
all patients. There is a need for further studies on this subject.

Keywords

Diabetic neuropathy, cardiovascular risk, monocyte/HDL-C

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