Tip 1 Diyabetli Kız Olgularda Glisemik Kontrolün Plazma Ghrelin ve Serum IGF-1 Düzeylerine Etkisi

Year 2010, Volume: 8 Issue: 1, 104 - 110, 01.06.2010

Tolga Altuğ Şen Reşit Köken Tevfik Demir Ayşegül Bükülmez

Abstract

Giriş: Çalışmamızda Tip 1 diyabetli kız olgularda glisemik kontrolün plazma ghrelin düzeyleri ve serum IGF-1 düzeyleri üzerine etkisini göstermeyi amaçladık.Gereç ve Yöntem: Çalışmamızda yaşları 14-20 yıl arasında, puberte Tanner evre 5 olan32 tip 1 diyabetli kız olgu seçildi. Bu olgular son 1 yıllık ortalama glikozile hemoglobin ölçümlerine göre 18’i metabolik kontrolü iyi, 14’ü metabolik kontrolü kötü olarak 2 grubaayrıldılar. Kontrol grubu olarak yaş ve puberte açısından benzer 15 sağlıklı kız çocuk seçildi. Olguların sabah açlık plazma ghrelin düzeyleri ve serum IGF-1 düzeyleri ölçüldü.Bulgular: Ortalama ghrelin düzeyleri metabolik kontrolü iyi olan tip 1 diyabetli olgularda483,4±221,9 pg/ml, metabolik kontrolü kötü olan olgularda 310,7±110,2 pg/ml ve sağlıklıkontrollerde 471,9±175,0 pg/ml bulundu. Ortalama IGF-1 düzeyleri iyi metabolik kontrollüolgularda 233,9±59,2 ng/ml, kötü metabolik kontrollü olgularda 183,9±36,7 ng/ml, sağlıklıkontrollerde ise 247,3±48,5 ng/ml bulundu. İyi metabolik kontrollü olgularla sağlıklı kontroller arasında plazma ghrelin ve serum IGF-1 düzeyleri için anlamlı fark yoktu. Metabolik kontrolü kötü olan diyabetlilerde ghrelin ve IGF-1 düzeylerinin diğer iki gruba göre baskılandığı gözlendi. Sonuç: Tip 1 diyabetli olgularda metabolik kontrol plazma ghrelin ve serum IGF-1 düzeyleri için belirleyici bir faktör olabilir. Metabolik kontrolü iyi olan olgularda ghrelinve IGF-1 düzeyleri kontrol grubundaki olgularla benzer bulunurken, metabolik kontrolü kötü olan olgularda ghrelin ve IGF-1 düzeylerinin baskılandığı görülmüştür

Keywords

Ghrelin, IGF-1, diyabet

The Effect of Glycemic Control on Plasma Ghrelin and Serum IGF-1 Levels in Type 1 Diabetic Girls

Abstract

Introduction: The aim of this study was to investigate the effect of glycemic control onplasma ghrelin levels and serum IGF-1 levels in girls with type 1 diabetes. Materials and Method: The study group composed of 32 diabetic girls between theages of 14.0-20.0 years with Tanner pubertal stage 5; and 15 healthy girls in similar ageswith Tanner pubertal stage 5 formed the control group. Diabetic girls were classified aswell glycemic controlled n=18 and poor glycemic controlled n=14 according to lastyear’s mean glycosylated hemoglobin levels. All subjects were tested for fasting plasma ghrelin and serum IGF-1 levels. Results: The mean fasting plasma ghrelin levels in girls with well controlled diabetes, ingirls wtih poor controlled diabetes and in control group were 483.4±221.9 pg/ml,310.7±110.2 pg/ml, 471.9±175.0 pg/ml respectively. The mean serum IGF-1 levels in girlswith well controlled diabetes was 233.9±59.2 ng/ml, in girls with poor controlled diabetes183.9±36.7 ng/ml, and in healthy controls 247.3±48.5 ng/ml. Plasma ghrelin levels and serum IGF-1 levels were similar in girls with well controlled diabetes and in the controlgroup, however it was significantly supressed in those with poorly controlled diabetes. Conclusion: The metabolic control may be a determinative factor on plasma ghrelin andserum IGF-1 levels of type 1 diabetics. Plasma ghrelin and serum IGF-1 levels were similarin well glycemic controlled diabetics and control group, while they were suppressed inonly poor glycemic controlled diabetics

Keywords

Ghrelin, IGF-1, diabetes

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