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Hemofagositik Lenfohistiyositozis

Year 2004, Volume: 2 Issue: 4, 113 - 116, 01.12.2004

Özcan Bör

Abstract

Hemofagositik lenfohistiyositozis HLH nadir görülen fatal seyirli bir fenomendir. Hemofagositozla karakterize malign olmayan immün regülasyon bozukluğudur. T lenfositler ve makrofajların kontrol edilemeyen aktivasyonu ve inflamatuar sitokinlerin İnterferon gama, interlökin-1, interlökin-6, tümör nekrozis faktör gibi aşırı üretimi vardır.

References

  • 1. Janka GE. Familial hemophagocytic lymphohistiocytosis. Eur J Pediatr, 1983; 140: 221-30.
  • 2. Henter JI, Elinder G, Öst A, and the FHL Study Group of the Histiocyte Society. Diagnostic guidelines for hemophagocytic lymphohistiocyto￾sis. Semin Oncol 1991;18: 29-33.
  • 3. Arico M, Janka G, Fischer A, et al. Hemophagocytic Lymphohistiocyto￾sis: Diagnosis, treatment and prognostic factors. Report of 122 child￾ren from the International Registry. Leukemia 1996; 10: 197-203.
  • 4. Imashuku S, Hlbi S, Todo S. Hemophagocytic lymphohistiocytosis in in￾fancy and childhood. J Pediatr, 1997; 130: 352-7.
  • 5. Ramanan AV, Baildam EM, Wynn RF. Macrophage activation syndrome is hemophagocytic lymphohistiocytosis-need for the right terminology. J Rheumatol 2002; 29: 1105.
  • 6. Janka G, Imashuku S, Elinder G, Schneider M, Henter JI. Infection- and Ma￾lignancy-Associated Hemophagocytic Syndromes: Secondary hemopha￾gocytic lymphohistiocytosis. Hematol Oncol Clin North Am 1998; 12: 435-44.
  • 7. Dufourcq-Lagelouse R, Pastural E, et al. Genetic basis of hemopha￾gocytic lymphohistiocytosis syndrome. International Journal of Mole￾cular Medicine 1999; 4: 127-33.
  • 8. Osugi Y, Hara J, Tagawa S. et al. Cytokine production regulating Th1 and Th2 cytokines in hemophagocytic lymphohistiocytosis. Blood 1997; 89: 4100-3.
  • 9. Teruya-Feldstein J, Setsuda J, Yao X, Kingma DW, Straus S, Tosato G, Jaffe S. MIP-1 expression in tissues from patients with hemophagocy￾tic syndrome. Lab Invest 1999; 79: 1583-90.
  • 10. Schneider EM, Lorenz I, Müller-Rosenberger M, et al. Hemophagocytic lymphohistiocytosis is associated with deficiencies of cellular cytoly￾sis but normal expression of transcripts relevant to killer-cell-induced apoptosis. Blood 2002; 100: 2891-8.
  • 11. Komp DM, McNamara J, Buckley P. Elevated soluble interleukin-2 re￾ceptor in childhood hemophagocytic histiocytic syndromes. Blood 1989; 73: 1228-32.
  • 12. Stepp SE, Dufourcq-Lagelouse R, Le Deist F et al. Perforin gene defects in familial hemophagocytic lymphohistiocytosis. Science 1999; 286: 1957-9.
  • 13. Henter JI, Aricò M, Elinder G, Imashuku S, Janka G. Familial Hemopha￾gocytic Lymphohistiocytosis (Primary HLH). Hematol Oncol Clin North Am 1998; 12: 417-33.
  • 14. Ericson KG, Fadeel B, Nilsson-Ardnor S, et al. Spectrum of perforin ge￾ne mutations in familial hemophagocytic lymphohistiocytosis. Am J Hum Genet 2001; 68: 590-7.
  • 15. Henter JI, Elinder G, Söder O, et al. Incidence and clinical features of familial hemophagocytic lymphohistiocytosis in Sweden. Acta Paedi￾atr Scand 1991;80: 428.
  • 16. Feldmann, J, Callebaut I, Raposo G, et al. Munc 13-4 is Essential for cytolytic granules fusion and is mutated in a form of familial hemopha￾gocytic lymphohidtiocytosis (FHL3). Cell 2002; 115: 461-73.
  • 17. Janka GE, Schneider EM. Modern management of children with ha￾emophagocytic lymphohistiocytosis. Br J Haematol. 2004; 124: 4-14.
  • 18. Lacz LL. Lymphohistiocytosis. www.emedicine.com/ped/topic745.htm 2004
  • 19. Sung L, King SM, Carcao M, Trebo M, Weitzman SS. Adverse outcomes in primary hemophagocytic lymphohistiocytosis. J Pediatr Hematol Oncol. 2002; 24: 550-4.
  • 20. Risdall RJ, McKenna RW, Nesbit ME, et al. Virus-associated hemopha￾gocytic syndrome. Cancer 1979; 44: 993-1002.
  • 21. Fisman DN. Hemophagocytic Syndromes and Infection. Emerg Infect Dis. 2000; 6: 601-8.
  • 22. Henter JI and Hemophagocytic Lymphohistiocytosis Study Group. Tre￾atment Protocol of The Second International HLH Study Sweden 2004. (groups.yahoo.com/group/turkhistiosit /files/HLH 2004)
  • 23. Celkan T, Pat›ro¤lu T, Özyürek E, ve ark. Sekonder lenfohistiositik hemo￾fagositoz ulusal veriler (6 merkezli çal›flma). Turkish Journal of Haema￾tology (suppl) 2004; 21: 171.
  • 24. Henter JI. Hemophagocytic Lymphohistiocytosis (HLH)- Symptoms, signs and diagnosis of a rapidly fatal childhood disease. www.his￾tio.org/society/HLH/henter1.shtml 2004.
  • 25. Listinsky CM. Common reactive erythrophagocytosis in axillary lymph nodes. Am J Clin Pathol 1988; 90: 189-92.
  • 26. Suster S, Hilsenbeck S, Rywlin AM. Reactive histiocytic hyperplasia with hemophagocytosis in hematopoietic organs: a reevaluation of the benign hemophagocytic proliferations. Hum Pathol. 1988; 19: 705-12.
  • 27. Henter JI, Samuelsson-Horne AC, Aricò M, et al. Treatment of Hemop￾hagocytic Lymphohistiocytosis with HLH-94 Immuno-Chemotherapy and Bone Marrow Transplantation. Blood 2002; 100: 2367-73.
  • 28. Henter JI, Arico M, Egeler M, et al. HLH- 94: A treatment protocol for hemophagocytic lymphohistiocytosis. Med Pediatr Oncol 1997; 28: 342-47.

Year 2004, Volume: 2 Issue: 4, 113 - 116, 01.12.2004

Özcan Bör

Abstract

References

  • 1. Janka GE. Familial hemophagocytic lymphohistiocytosis. Eur J Pediatr, 1983; 140: 221-30.
  • 2. Henter JI, Elinder G, Öst A, and the FHL Study Group of the Histiocyte Society. Diagnostic guidelines for hemophagocytic lymphohistiocyto￾sis. Semin Oncol 1991;18: 29-33.
  • 3. Arico M, Janka G, Fischer A, et al. Hemophagocytic Lymphohistiocyto￾sis: Diagnosis, treatment and prognostic factors. Report of 122 child￾ren from the International Registry. Leukemia 1996; 10: 197-203.
  • 4. Imashuku S, Hlbi S, Todo S. Hemophagocytic lymphohistiocytosis in in￾fancy and childhood. J Pediatr, 1997; 130: 352-7.
  • 5. Ramanan AV, Baildam EM, Wynn RF. Macrophage activation syndrome is hemophagocytic lymphohistiocytosis-need for the right terminology. J Rheumatol 2002; 29: 1105.
  • 6. Janka G, Imashuku S, Elinder G, Schneider M, Henter JI. Infection- and Ma￾lignancy-Associated Hemophagocytic Syndromes: Secondary hemopha￾gocytic lymphohistiocytosis. Hematol Oncol Clin North Am 1998; 12: 435-44.
  • 7. Dufourcq-Lagelouse R, Pastural E, et al. Genetic basis of hemopha￾gocytic lymphohistiocytosis syndrome. International Journal of Mole￾cular Medicine 1999; 4: 127-33.
  • 8. Osugi Y, Hara J, Tagawa S. et al. Cytokine production regulating Th1 and Th2 cytokines in hemophagocytic lymphohistiocytosis. Blood 1997; 89: 4100-3.
  • 9. Teruya-Feldstein J, Setsuda J, Yao X, Kingma DW, Straus S, Tosato G, Jaffe S. MIP-1 expression in tissues from patients with hemophagocy￾tic syndrome. Lab Invest 1999; 79: 1583-90.
  • 10. Schneider EM, Lorenz I, Müller-Rosenberger M, et al. Hemophagocytic lymphohistiocytosis is associated with deficiencies of cellular cytoly￾sis but normal expression of transcripts relevant to killer-cell-induced apoptosis. Blood 2002; 100: 2891-8.
  • 11. Komp DM, McNamara J, Buckley P. Elevated soluble interleukin-2 re￾ceptor in childhood hemophagocytic histiocytic syndromes. Blood 1989; 73: 1228-32.
  • 12. Stepp SE, Dufourcq-Lagelouse R, Le Deist F et al. Perforin gene defects in familial hemophagocytic lymphohistiocytosis. Science 1999; 286: 1957-9.
  • 13. Henter JI, Aricò M, Elinder G, Imashuku S, Janka G. Familial Hemopha￾gocytic Lymphohistiocytosis (Primary HLH). Hematol Oncol Clin North Am 1998; 12: 417-33.
  • 14. Ericson KG, Fadeel B, Nilsson-Ardnor S, et al. Spectrum of perforin ge￾ne mutations in familial hemophagocytic lymphohistiocytosis. Am J Hum Genet 2001; 68: 590-7.
  • 15. Henter JI, Elinder G, Söder O, et al. Incidence and clinical features of familial hemophagocytic lymphohistiocytosis in Sweden. Acta Paedi￾atr Scand 1991;80: 428.
  • 16. Feldmann, J, Callebaut I, Raposo G, et al. Munc 13-4 is Essential for cytolytic granules fusion and is mutated in a form of familial hemopha￾gocytic lymphohidtiocytosis (FHL3). Cell 2002; 115: 461-73.
  • 17. Janka GE, Schneider EM. Modern management of children with ha￾emophagocytic lymphohistiocytosis. Br J Haematol. 2004; 124: 4-14.
  • 18. Lacz LL. Lymphohistiocytosis. www.emedicine.com/ped/topic745.htm 2004
  • 19. Sung L, King SM, Carcao M, Trebo M, Weitzman SS. Adverse outcomes in primary hemophagocytic lymphohistiocytosis. J Pediatr Hematol Oncol. 2002; 24: 550-4.
  • 20. Risdall RJ, McKenna RW, Nesbit ME, et al. Virus-associated hemopha￾gocytic syndrome. Cancer 1979; 44: 993-1002.
  • 21. Fisman DN. Hemophagocytic Syndromes and Infection. Emerg Infect Dis. 2000; 6: 601-8.
  • 22. Henter JI and Hemophagocytic Lymphohistiocytosis Study Group. Tre￾atment Protocol of The Second International HLH Study Sweden 2004. (groups.yahoo.com/group/turkhistiosit /files/HLH 2004)
  • 23. Celkan T, Pat›ro¤lu T, Özyürek E, ve ark. Sekonder lenfohistiositik hemo￾fagositoz ulusal veriler (6 merkezli çal›flma). Turkish Journal of Haema￾tology (suppl) 2004; 21: 171.
  • 24. Henter JI. Hemophagocytic Lymphohistiocytosis (HLH)- Symptoms, signs and diagnosis of a rapidly fatal childhood disease. www.his￾tio.org/society/HLH/henter1.shtml 2004.
  • 25. Listinsky CM. Common reactive erythrophagocytosis in axillary lymph nodes. Am J Clin Pathol 1988; 90: 189-92.
  • 26. Suster S, Hilsenbeck S, Rywlin AM. Reactive histiocytic hyperplasia with hemophagocytosis in hematopoietic organs: a reevaluation of the benign hemophagocytic proliferations. Hum Pathol. 1988; 19: 705-12.
  • 27. Henter JI, Samuelsson-Horne AC, Aricò M, et al. Treatment of Hemop￾hagocytic Lymphohistiocytosis with HLH-94 Immuno-Chemotherapy and Bone Marrow Transplantation. Blood 2002; 100: 2367-73.
  • 28. Henter JI, Arico M, Egeler M, et al. HLH- 94: A treatment protocol for hemophagocytic lymphohistiocytosis. Med Pediatr Oncol 1997; 28: 342-47.
There are 28 citations in total.

Details

Primary Language Turkish
Journal Section Collection
Authors

Özcan Bör

Publication Date December 1, 2004
Published in Issue Year 2004 Volume: 2 Issue: 4

Cite

APA Bör, Ö. (2004). Hemofagositik Lenfohistiyositozis. Güncel Pediatri, 2(4), 113-116.
AMA Bör Ö. Hemofagositik Lenfohistiyositozis. Güncel Pediatri. December 2004;2(4):113-116.
Chicago Bör, Özcan. “Hemofagositik Lenfohistiyositozis”. Güncel Pediatri 2, no. 4 (December 2004): 113-16.
EndNote Bör Ö (December 1, 2004) Hemofagositik Lenfohistiyositozis. Güncel Pediatri 2 4 113–116.
IEEE Ö. Bör, “Hemofagositik Lenfohistiyositozis”, Güncel Pediatri, vol. 2, no. 4, pp. 113–116, 2004.
ISNAD Bör, Özcan. “Hemofagositik Lenfohistiyositozis”. Güncel Pediatri 2/4 (December 2004), 113-116.
JAMA Bör Ö. Hemofagositik Lenfohistiyositozis. Güncel Pediatri. 2004;2:113–116.
MLA Bör, Özcan. “Hemofagositik Lenfohistiyositozis”. Güncel Pediatri, vol. 2, no. 4, 2004, pp. 113-6.
Vancouver Bör Ö. Hemofagositik Lenfohistiyositozis. Güncel Pediatri. 2004;2(4):113-6.