Psychobiotics and Elderly Health

Abstract

While aging with physiological dimensions refers to the changes seen with chronological age, on the other hand, aging with psychological dimensions refers to the change of humans’ capacity to adaptively. Such as learning, psychomotor, problem-solving and personality traits. With the improvement of life quality in recent years, the average life expectancy and therefore the incidence of neurodegenerative diseases among the elderly have also increased. Although the aging process is universal, progressive, gradual and unstoppable, human gut microbiota-targeted aging management is a new approach to health and anti-aging. Nutrition plays a big factor in the elderly population with providing adequate cognitive and physical functions and when taking the right nutrition it also reduces the risk of chronic diseases. When adding functional foods into the diet, it can play a significant role to reduce the risk of diet-related diseases. Such as probiotics and prebiotics. In recent years, a new subclass of probiotics called ‘psychobiotics’ has emerged. These psychobiotics are defined as probiotics that, when taken in appropriate amounts, it creates positive psychiatric effects in human psychopathology. Examination of this new class of probiotics provides a glimmer of hope for the effective management of neurodegenerative diseases and various psychiatric disorders, especially with increasing life expectancy. Also, recommending the use of probiotics in old age will contribute to the treatment of some health problems related to aging.

Keywords

• Probiotics
• elderly
• diet
• food
• nutrition

Psikobiyotikler ve Yaşlı Sağlığı

Abstract

Fizyolojik boyutuyla yaşlanma kronolojik yaşla birlikte görülen değişiklikleri ifade ederken, psikolojik boyutuyla yaşlanma; kronolojik yaş ilerledikçe görülen öğrenme, psikomotor aktivite,problem çözme ve kişilik özellikleri açısından insanın uyum kapasitesindeki değişimi ifade eder.Son yıllarda yaşam kalitesinin yükselmesiyle ortalama yaşam süresi, dolayısıyla yaşlılar arasında nörodejeneratif hastalıkların görülme sıklığı artmıştır. Yaşlanma süreci evrensel, ilerleyici, kademeli ve engellenemez olmasına rağmen, insan bağırsağı mikrobiyota hedefli yaşlanma yönetimi, sağlığı ve yaşlanmayı önlemede yeni bir yaklaşımdır. Yaşlı popülasyonda yeterli bilişsel ve fiziksel fonksiyonların sağlanması ve kronik hastalık riskinin azaltılması için beslenme büyük önem taşımaktadır. Sağlıklı ve dengeli beslenme adına, fonksiyonel besinlerin diyete sokularak, diyetle ilişkili hastalık riskinin azaltılması hedeflenmiştir. Bu fonksiyonel besinlerden bir kaçı da probiyotikler ve prebiyotiklerdir. Son yıllarda, ‘psikobiyotikler’ adı verilen yeni bir probiyotik alt sınıfı ortaya çıkmıştır. Bu psikobiyotikler ilk olarak uygun miktarlarda alındığında psikopatolojide olumlu psikiyatrik etkiler yaratan probiyotikler olarak tanımlanır. Bu yeni probiyotik sınıfının incelenmesi, özellikle yaşam süresinin uzamasıyla artan nörodejeneratif hastalıkların ve çeşitli psikiyatrik bozuklukların etkin yönetimi için umut ışığı oluşturmaktadır. Yaşlılıkta probiyotik kullanımının tavsiye edilmesinin, yaşlılıkla ilgili bazı sağlık problemlerinin tedavisine katkı sağlayacağı unutulmamalıdır.

Keywords

• Probiyotikler
• yaşlı
• diyet
• besin
• beslenme

References

1. Allen AP, Hutch W, Borre YE, Kennedy PJ, Temko A, Boylan G et al. (2016) Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers. Transl Psychiatry,11:939.
2. Akbari E, Asemi Z, Daneshvar Kakhaki R, Bahmani F, Kouchaki E, Tamtaji OR et al. (2016) Effect of probiotic supplementation on cognitive function and metabolic status in Alzheimer’s disease: a randomized, double-blind and controlled trial. Front Aging Neurosci, 8:256.
3. Akçakaya A, Tengiz Fİ (2020) The effect of diet and nutritional elements on gut microbiota. Demiroğlu Bilim Üniversitesi Florence Nightingale Tıp Dergisi, 6:28-35.
4. Athari Nik Azm S, Djazayeri A, Safa M, Azami K, Ahmadvand B, Sabbaghziarani F et al. (2018) Lactobacilli and bifidobacteria ameliorate memory and learning deficits and oxidative stress in β-amyloid (1–42) injected rats. Appl Physiol Nutr Metab, 43:718-726.
5. Barrett E, Ross R.P, O'Toole PW, Fitzgerald GF, Stanton C (2012) Aminobutyric acid production by culturable bacteria from the human intestine. J Appl Microbiol,113:411-417.
6. Bedarf JR, Hildebrand F, Coelho LP, Sunagawa S, Bahram M, Goeser F et al. (2017) Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naïve Parkinson’s disease patients. Genome Med, 9:39.
7. Borzabadi S, Oryan S, Eidi A, Aghadavod E, Kakhaki RD, Tamtaji OR et al.(2018) The effects of probiotic supplementation on gene expression related to inflammation, insulin and lipid in patients with Parkinsons disease: A randomized, double-blind, placebo-controlled trial. Arch Iran Med, 21:289-295.
8. Brewster G, Riegel B, Gehrman PR (2018) Insomnia in the older adult. Sleep Med Clin, 13:13-19.

9. Cassani E, Privitera G, Pezzoli G, Pusani C, Madio C, Iorio L et al. (2011) Use of probiotics for the treatment of constipation in Parkinson's disease patients. Minerva Gastroenterol Dietol, 57:117-121.
10. Claesson MJ, Jeffery IB, Conde S, Power SE, O’connor EM, Cusack S et al. (2012) Gut microbiota composition correlates with diet and health in the elderly. Nature, 488:178-184.
11. Clarke G, Grenham S, Scully P, Fitzgerald P, Moloney RD, Shanahan F et al. (2013) The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol Psychiatry, 18:666-673.
12. Cryan JF, O'Riordan KJ, Cowan CS, Sandhu KV, Bastiaanssen TF, Boehme M et al. (2019) The microbiota-gut-brain axis. Physiol Rev, 99:1877–2013.
13. Cohen Kadosh K, Basso M, Knytl P, Johnstone N, Lau J, Gibson GR (2021) Psychobiotic interventions for anxiety in young people: a systematic review and meta-analysis, with youth consultation. Transl Psychiatry, 11:352.
14. DeJong EN, Surette MG, Bowdish DM (2020) The gut microbiota and unhealthy aging: disentangling cause from consequence. Cell Host Microbe, 28: 180-189.
15. Dinan TG, Stanton C,Cryan JF (2013) Psychobiotics: a novel class of psychotropic. Biol Psychiatry, 74:720-726.
16. Dinan TG, Cryan JF (2017) The microbiome-gut-brain axis in health and disease. Gastroenterol Clin, 46:77-89.
17. Elfil M, Kamel S, Kandil M, Koo BB, Schaefer SM (2020) Implications of the gut microbiome in Parkinson's disease. Mov Disord, 35:921-933.
18. Georgescu D, Ancusa OE, Georgescu LA, Ionita I, Reisz D (2016) Nonmotor gastrointestinal disorders in older patients with Parkinson’s disease: is there hope? Clin Interv Aging, 11:1601-1608.
19. Göktaş K, Özkan İ (2006) Yaşlılarda depresyon. Türkiye'de Psikiyatri Dergisi, 8:30-37.
20. Karatay E (2019) Mikrobiyota, prebiyotik ve probiyotikler. Anadolu Güncel Tıp Dergisi, 1:68-71.
21. Kim S, Jazwinski SM (2018) The gut microbiota and healthy aging: a mini-review. Gerontology, 64:513-520.
22. Kumar A, Singh A (2015) A review on Alzheimer's disease pathophysiology and its management: an update. Pharmacol Rep, 67:195-203.
23. Kumari R, Singh A, Yadav AN, Mishra S, Sachan A, Sachan SG (2020) Probiotics, prebiotics, and synbiotics: Current status and future uses for human health. In New and Future Developments in Microbial Biotechnology and Bioengineering (Eds AA Rastegari, AN Yadav, N Yadav):173-190. Amsterdam, Elsevier. Lee JS, Gundersen C, Cook J, Laraia B, Johnson MA (2012) Food insecurity and health across the lifespan. Adv Nutr, 3:744-745.
24. Li YR, Li S, Lin CC (2018) Effect of resveratrol and pterostilbene on aging and longevity. Biofactors, 44:69-82.
25. Liang S, Wang T, Hu X, Luo J, Li W, Wu X et al. (2015) Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress. Neuroscience, 310:561-577.
26. Lin A, Shih CT, Huang CL, Wu CC, Lin CT, Tsai YC (2019) Hypnotic effects of lactobacillus fermentum PS150TM on pentobarbital-induced sleep in mice. Nutrients, 11:2409.
27. Ling Z, Liu X, Cheng Y, Yan X, Wu S (2020) Gut microbiota and aging. Crit Rev Food Sci Nutr,1:1-56.
28. Liu Z, Zhang A, Sun H, Han Y, Kong L, Wang X (2017) Two decades of new drug discovery and development for Alzheimer’s disease. RSC Adv, 7:6046-6058.
29. Liu YW, Liu WH, Wu CC, Juan YC, Wu YC, Tsai HP et al. (2016) Psychotropic effects of Lactobacillus plantarum PS128 in early life-stressed and naïve adult mice. Brain Res, 1631:1-12.
30. Lu CS, Chang HC, Weng YH, Chen CC, Kuo YS, Tsai YC (2021) The add-on effect of lactobacillus plantarum pS128 in patients with Parkinson’s disease: a pilot study. Front Nutr, 8:650053.
31. Lu Y, Christian K, Lu B (2008) BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory? Neurobiol Learn Mem, 89:312-323.
32. Luang-In V, Katisart T, Konsue A, Nudmamud-Thanoi S, NarbAH A, Saengha W et al. (2020) Psychobiotic effects of multi-strain probiotics originated from Thai fermented foods in a rat model. Food Sci Anim Resour, 40:1014.
33. Mateos I, Combes S, Pascal G, Cauquil L, Barilly C, Cossalter A et al. (2018) Fumonisin-exposure impairs age-related ecological succession of bacterial species in weaned pig gut microbiota. Toxins, 10:230.
34. Ma Q, Xing C, Long W, Wang HY, Liu Q, Wang RF (2019) Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis. J Neuroinflammation, 16:53.
35. Mattson MP, Arumugam TV (2018) Hallmarks of brain aging: adaptive and pathological modification by metabolic states. Cell Metab, 27:1176-1199.
36. Messaoudi M, Lalonde R, Violle N, Javelot H, Desor D, Nejdi A et al.(2011). Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br J Nutr, 105:755-764.
37. Messaoudi M, Violle N, Bisson J.F, Desor D, Javelot H, Rougeot C (2011) Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers. Gut Microbes, 2:256-261.
38. Misra S,Mohanty D (2019) Psychobiotics: A new approach for treating mental illness? Crit Rev Food Sci Nutr, 59:1230-1236.
39. Miyazaki K, Itoh N, Yamamoto S, Higo-Yamamoto S, Nakakita Y, Kaneda H et al. (2014) Dietary heat-killed Lactobacillus brevis SBC8803 promotes voluntary wheel-running and affects sleep rhythms in mice. Life Sci, 111:47-52.
40. Morin CM, Benca R (2012) Chronic insomnia. Lancet, 379:1129-1141.
41. Mörkl S, Butler MI, Holl A, Cryan JF, Dinan TG (2020) Probiotics and the microbiota-gut-brain axis: focus on psychiatry. Curr Nutr Rep, 9:171-182.
42. O’Toole PW, Jeffery IB (2015) Gut microbiota and aging. Science, 350:1214-1215.
43. Orr WC, Chen CL (2005) Sleep and the gastrointestinal tract. Neurol Clin, 23:1007-1024.
44. Öğüt S, Polat M, Orhan H (2008) Isparta ve Burdur huzurevlerinde kalan yaşlıların sosyodemografik durumları ve beslenme tercihleri. Turk Geriatri Derg,11:82–87.
45. Öksüzokyar MM, Eryiğit SÇ, Öğüt DK, Erdoğmuş MB, Sökmen ÜN, Öğüt S (2016) Biyolojik yaşlanma nedenleri ve etkileri. Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 4:34-41.
46. Özden D, Kelleci M, Güler N (2010) Yaşlı bireylerin ruh sağlığının şiddete maruz kalma ve bazı özellikler açısından incelenmesi. Hemşirelikte Araştırma Geliştirme Dergisi, 12:5-13.
47. Parekh PJ, Oldfield IV EC, Johnson DA (2018) The effects of sleep on the commensal microbiota: eyes wide open? J Clin Gastroenterol, 52:204-209.
48. Parkar SR (2015) Elderly mental health: needs. Mens Sana Monogr, 13:91.
49. Patel D, Steinberg J, Patel P (2018) Insomnia in the elderly: a review. J Clin Sleep Med, 14:1017-1024.
50. Patterson C (2018) World Alzheimer Report 2018: What Causes Dementia? The Basic Science, 2nd ed. London, Alzheimer’s Disease International.
51. Pinto-Sanchez MI, Hall GB, Ghajar K, Nardelli A, Bolino C, Lau,JT et al. (2017) Probiotic bifidobacterium longum NCC3001 reduces depression scores and alters brain activity: a pilot study in patients with irritable bowel syndrome. Gastroenterology, 153: 448-459.
52. Poirier AA, Aubé B, Côté M, Morin N, Di Paolo T, Soulet D (2016) Gastrointestinal dysfunctions in Parkinson’s disease: symptoms and treatments. Parkinsons Dis, 2016:6762528..
53. Prince M, Wimo A, Guerchet M, Ali G.C, Wu Y.T, Prina M (2015) World Alzheimer Report 2015. London, Alzheimer’s Disease International.
54. Roshchina VV (2016) New trends and perspectives in the evolution of neurotransmitters in microbial, plant, and animal cells. Adv Exp Med Biol, 874:25–77 .
55. Sakin Y, Tanoğlu A (2016) Prebiyotikler ve insan sağlığı üzerindeki etkileri. Medicine Science, 5:210-223. Scheperjans F, Aho V, Pereira PA, Koskinen K, Paulin L, Pekkonen E et al. (2015) Gut microbiota are related to Parkinson's disease and clinical phenotype. Mov Disord, 30:350-358.
56. Sun J, Liu S, Ling Z, Wang F, Ling Y, Gong T et al.(2019) Fructooligosaccharides ameliorating cognitive deficits and neurodegeneration in APP/PS1 transgenic mice through modulating gut microbiota. J Agric Food Chem, 67:3006-3017.
57. Tamtaji OR, Taghizadeh M, Kakhaki RD, Kouchaki E, Bahmani F, Borzabadi S et al.(2019) Clinical and metabolic response to probiotic administration in people with Parkinson's disease: a randomized, double-blind, placebo-controlled trial. Clin Nutr, 38:1031-1035.
58. Taylor JM, Main BS,Crack PJ (2013) Neuroinflammation and oxidative stress: co-conspirators in the pathology of Parkinson’s disease. Neurochem Int, 62:803-819.
59. TUIK (2020) Ölüm ve Ölüm Nedeni İstatistikleri. TÜIK Haber Bülteni, 24.06.2020:33710.
60. Yamamura S, Morishima H, Kumano-go T, Suganuma N, Matsumoto H, Adachi H et al. (2009) The effect of Lactobacillus helveticus fermented milk on sleep and health perception in elderly subjects. Eur J Clin Nutr, 63:100-105.
61. Wan YW, Al-Ouran R, Mangleburg CG, Perumal TM, Lee TV, Allison K et al. (2020) Meta-analysis of the Alzheimer’s disease human brain transcriptome and functional dissection in mouse models. Cell Rep, 32:107908.
62. WHO (2011) Global Health and Aging. Geneva, World Health Organization.