Neuroimaging in Antisocial Personality Disorder

Abstract

Neuroimaging has been used in antisocial personality disorder since the invention of computed tomography and new modalities are introduced as technology advances. Magnetic resonance imaging, diffusion tensor imaging, functional magnetic resonance imaging and radionuclide imaging are such techniques that are currently used in neuroimaging. Although neuroimaging is an indispensible tool for psychiatric reseach, its clinical utility is questionable until new modalities become more accessible and regularly used in clinical practice. The aim of this paper is to provide clinicians with an introductory knowledge on neuroimaging in antisocial personality disorder including basic physics principles, current contributions to general understanding of pathophysiology in antisocial personality disorder and possible future applications of neuroimaging.

Keywords

• Antisocial personality disorder, neuroimaging, computed tomography, magnetic resonance imaging

Antisosyal Kişilik Bozukluğunda Nörogörüntüleme

Öz

Antisosyal kişilik bozuklukluğu olan olgularda nörogörüntüleme, bilgisayarlı tomografinin uygulamaya girmesinden bu yana gündemde olan bir konudur. Teknolojinin ilerlemesi ile birlikte daha yeni görüntüleme modaliteleri kullanıma sunulmuş olup magnetik rezonans görüntüleme, magnetik rezonans spektroskopi, difüzyon tensör görüntüleme, fonksiyonel magnetic rezonans görüntüleme ve radyonüklid görüntüleme konunun araştırılmasında kullanım alanı bulmuştur. Psikiyatrik araştırmalarda nörogörüntüleme eşsiz bir araç olmakla birlikte, yeni modaliteler daha kolay ulaşılabilir ve elde edilen veriler daha kolay yorumlanabilir ve tedaviyi yönlendirebilecek nitelikte olana dek klinik pratikte kullanım alanı bulma ihtimali azdır. Bu yazının amacı klinisyene antisosyal kişilik bozukluğunda kullanılan görüntüleme yöntemlerinin temel fizik prensipleri, bu olgulardaki patofizyolojinin anlaşılmasına mevcut katkıları ve gelecekte olası kullanım alanlarından oluşan nörogörüntülemeye giriş seviyesinde bilgiler sunmaktır.

Anahtar Kelimeler

• Antisosyal kişilik bozukluğu, nörogörüntüleme, bilgisayarlı tomografi, magnetik rezonans görüntüleme

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