Folate, B12 and Iron Levels in COVID 19 Patients Observational Case-Control Study

Abstract

Background: Folic acid, B12 and Iron play an important role in the pathogenesis of viral infections. Aim: The aim of the study is to determine the blood levels of Folate, B12 and Iron and to examine their relationship with prognosis in cases followed up by the COVID 19 pandemic service. Materials and Methods: The study was planned as a retrospective observational case-control study. In a period of approximately 3 months, 140 patients were screened retrospectively, 70 of whom were COVID 19 and 70 control cases. Cases <18 years of age, followed up in the Intensive Care Unit or withdrawn from the Intensive Care Unit to the service, and patients taking drugs or supportive treatment that could affect blood Folate, B12, Iron levels were excluded from the study. p<0.05 was accepted as statistical significance level. Results: 48.6% (68) of the cases were male, 51.4% (72) were female. The mean age (mean±SD) of all cases was 67.3±15.8. No significant difference was observed between the case and control groups in terms of age, gender, presence of comorbid disease, prognosis, Folate and B12 levels. However, the iron level was significantly higher in the case group. Conclusion: As a result, Folic acid and B12 supplementation is needed in the majority of COVID 19 cases. Before supplementing with iron, the iron level should be checked.

Keywords

• covid 19
• ;b12
• ;folat
• ;iron

COVID 19 Hastalarında Folat, B12 ve Demir Düzeyleri Gözlemsel Vaka Kontrol Çalışması

Abstract

Giriş: Folik asit, B12 ve Demir özellikle viral enfeksiyonların patogenezinde önemli rol oynamaktadır. Amaç: Çalışmanın amacı COVİD 19 pandemi servis takibi yapılan vakalarda kanda Folat, B12 ve Demir düzeylerinin belirlenmesi ve prognoz ile ilişkilerinin irdelenmesi. Materyal ve Metot: Çalışma retrospektif gözlemsel olgu-kontrol çalışması olarak planlandı. Yaklaşık 3 aylık süreçte 70 COVİD 19, 70’de kontrol vakası olmak üzere 140 hasta retrospektif tarandı. <18 yaş, Yoğun Bakım Ünitesi’de takipli vakalar veya Yoğun Bakım Ünitesin’den servise çekilen vakalar ve kan Folat, B12, Demir düzeyini etkileyecek ilaçlar veya destek tedavisi alan hastalar çalışma dışı bırakıldı. İstatistiksel anlamlılık düzeyi olarak p<0.05 kabul edildi. Bulgular: Vakaların %48.6’sı (68) erkek, %51.4’ü (72) kadın cinsiyet idi. Tüm vakaların yaş ortalaması (Ort±SS) 67.3±15.8 idi. Olgu ve kontrol grupları arasında yaş, cinsiyet, komorbid hastalık varlığı, prognoz, Folat ve B12 düzeyleri açısından anlamlı fark gözlenmezken, Demir düzeyi olgu grubunda anlamlı oranda yüksekti. Sonuç: Sonuç olarak COVİD 19 vakalarının büyük çoğunluğunda Folik asit ve B12 takviyesine ihtiyaç duyulmaktadır. Demir takviyesi yapmadan önce ise mutlaka demir seviyesi bakılmalıdır.

Keywords

• covid 19
• ;b12
• ;folat
• ;demir

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