Biotransformation of Dehydroepiandrosterone by Penicillium olsonii MRC500780

Year 2024, , 1261 - 1266, 31.12.2024

Ali Kuru , Mena Albayaty

https://doi.org/10.16984/saufenbilder.1496783

Abstract

This work reported the biotransformation of dehydroepiandrosterone 1 with Penicillium olsonii MRC500780. Structure determinations revealed that biotransformation of 1 by Penicillium olsonii MRC500780 afforded androst-4-ene-3,17-dione 2, 15α-hydroxyandrost-4-ene-3,17-dione 3, 3β,7β-dihydroxyandrost-5-ene-17-one 4, 3β,7α-dihydroxyandrost-5-ene-17-one 5, and 15α,17β-dihydroxyandrost-4-ene-3-one 6. This fungus primarily isomerized the starting material in terms of the double bond and the hydroxyl group at 3β oxidised, then hydroxylated it at the C-15α position and reduced it at the C-17 position; also, hydroxylations at the C-7α position and C-7β position were observed.

Keywords

Penicillium olsonii, Dehydroepiandrosterone, Biotransformation

Supporting Institution

SAÜ BAPK

Project Number

2022-7-24-160

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