In this study, novel furfuryl-chalcone derivatives substituted sulfonyl chloride or sulphonamide were synthesized. Their antioxidant properties were investigated via DPPH and ABTS assays. All furfuryl-chalcones had high antioxidant properties. Among them, (E)-5-(3-(4-(chlorosulfonyl)-3-hydroxyphenyl)-3-oxoprop-1-en-1-yl)furan-2-sulfonyl chloride (4e) and (E)-5-(3-(3-(chlorosulfonyl)-4-hydroxyphenyl)-3-oxoprop-1-en-1-yl)furan-2-sulfonyl chloride (4d) exhibited the highest DPPH activity with the IC50 values of 4.23 μM and 6.68 μM, respectively, which are almost 2- and 1.5-fold more than quercetin activity (IC50 = 8.69 μM), well-known as antioxidant agent and used as a standard. Also, 4e and 4d had the highest ABTS activity with the IC50 value of 5.55 μM and 7.84 μM, respectively, which are almost 2.8- and 2-fold higher than that of quercetin (IC50 = 15.49 μM). The structure-activity relationship results revealed that most of synthesized sulfonyl chloride derivatives (4a-e) have higher antioxidant activity than the sulphonamide derivatives (5a-c) and also 4d and 4e, including hydroxyl group, exhibited the strongest antioxidant activity as expected.
Primary Language | English |
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Subjects | Engineering, Chemical |
Journal Section | Research Articles |
Authors |
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Publication Date | December 31, 2022 |
Submission Date | May 23, 2022 |
Acceptance Date | October 17, 2022 |
Published in Issue | Year 2022, Volume 26, Issue 6 |
Bibtex | @research article { saufenbilder1119766, journal = {Sakarya University Journal of Science}, eissn = {2147-835X}, address = {}, publisher = {Sakarya University}, year = {2022}, volume = {26}, number = {6}, pages = {1224 - 1232}, title = {Synthesis, DPPH and ABTS Activity of Novel Furfuryl-Chalcone Derivatives}, key = {cite}, author = {Sönmez, Fatih and Akgün, Enes and Şahin, Zuhal} } |
APA | Sönmez, F. , Akgün, E. & Şahin, Z. (2022). Synthesis, DPPH and ABTS Activity of Novel Furfuryl-Chalcone Derivatives . Sakarya University Journal of Science , 26 (6) , 1224-1232 . Retrieved from https://dergipark.org.tr/en/pub/saufenbilder/issue/74051/1119766 |
MLA | Sönmez, F. , Akgün, E. , Şahin, Z. "Synthesis, DPPH and ABTS Activity of Novel Furfuryl-Chalcone Derivatives" . Sakarya University Journal of Science 26 (2022 ): 1224-1232 <https://dergipark.org.tr/en/pub/saufenbilder/issue/74051/1119766> |
Chicago | Sönmez, F. , Akgün, E. , Şahin, Z. "Synthesis, DPPH and ABTS Activity of Novel Furfuryl-Chalcone Derivatives". Sakarya University Journal of Science 26 (2022 ): 1224-1232 |
RIS | TY - JOUR T1 - Synthesis, DPPH and ABTS Activity of Novel Furfuryl-Chalcone Derivatives AU - FatihSönmez, EnesAkgün, ZuhalŞahin Y1 - 2022 PY - 2022 N1 - DO - T2 - Sakarya University Journal of Science JF - Journal JO - JOR SP - 1224 EP - 1232 VL - 26 IS - 6 SN - -2147-835X M3 - UR - Y2 - 2022 ER - |
EndNote | %0 Sakarya University Journal of Science Synthesis, DPPH and ABTS Activity of Novel Furfuryl-Chalcone Derivatives %A Fatih Sönmez , Enes Akgün , Zuhal Şahin %T Synthesis, DPPH and ABTS Activity of Novel Furfuryl-Chalcone Derivatives %D 2022 %J Sakarya University Journal of Science %P -2147-835X %V 26 %N 6 %R %U |
ISNAD | Sönmez, Fatih , Akgün, Enes , Şahin, Zuhal . "Synthesis, DPPH and ABTS Activity of Novel Furfuryl-Chalcone Derivatives". Sakarya University Journal of Science 26 / 6 (December 2022): 1224-1232 . |
AMA | Sönmez F. , Akgün E. , Şahin Z. Synthesis, DPPH and ABTS Activity of Novel Furfuryl-Chalcone Derivatives. SAUJS. 2022; 26(6): 1224-1232. |
Vancouver | Sönmez F. , Akgün E. , Şahin Z. Synthesis, DPPH and ABTS Activity of Novel Furfuryl-Chalcone Derivatives. Sakarya University Journal of Science. 2022; 26(6): 1224-1232. |
IEEE | F. Sönmez , E. Akgün and Z. Şahin , "Synthesis, DPPH and ABTS Activity of Novel Furfuryl-Chalcone Derivatives", Sakarya University Journal of Science, vol. 26, no. 6, pp. 1224-1232, Dec. 2022 |
Sakarya University Journal of Science (SAUJS)