Design Error and Solution in Dry Powder Inhalers

Abstract

In this study, the design errors of dry powder inhaler devices that have been used for many years, and their solutions depending on these errors were investigated. For this study, the most recommended inhaler devices by doctors, and the most frequently used by patients are provided. The effective use of the device and the problems that arise during its use have been observed on many patients, and a newly designed inhaler device has been developed considering the emerging problems. Observations have revealed hesitations for patients to switch to the newly designed device due to old habits. However, in the studies conducted on patients who switched to the new design device, it is seen that there is a serious time reduction in the treatment processes if the device is used correctly.

Keywords

• powder inhaler
• respiratory system
• capsule blasting
• Patient

Kuru Toz İnhalerlerinde Tasarım Hatası ve Çözümü

Abstract

Bu çalışma da, uzun yıllardır kullanılan kuru toz inhaler cihazların tasarımsal olarak hataları ve bu hatalara bağlı olarak çözümleri araştırılmıştır. Bunun için doktorlar tarafından en çok tavsiye edilen ve hastalar tarafından en sık kullanılan inhaler cihazları temin edilmiştir. Cihazın etkin kullanımı ve kullanım esnasında ortaya çıkan sorunlar bir çok hasta üzerinde gözlemlenmiş ve ortaya çıkan sorunlar dikkate alınarak yeni dizayn bir inhaler cihazı geliştirilmiştir. Yapılan gözlemler, alışkanlıklardan dolayı hastaların yeni dizayn edilen cihaza geçmelerinde tereddütler ortaya çıkarmıştır. Ancak, yeni dizayn cihaza geçen hastalar üzerinde yapılan araştırmalarda, cihazın doğru biçimde kullanılması halinde tedavi süreçlerinde ciddi bir azalmanın oluştuğu görülmektedir.

Keywords

• Toz inhaler
• Solunum sistemi
• Kapsül püskürtme
• Ağız boşluğu
• Hasta

References

1. [1] S. Sorino, S. Negri, A. Spanevello, D. Visca, and N. Scichilone, “Inhalation therapy devices for the treatment of obstructive lung diseases: the history of inhalers towards the ideal inhaler,’’ Eur. J. Intern. Med., 75, 15-18, 2020.
2. [2] J. Schreiber, T. Sonnenburg, and E. Luecke, “Inhaler devices in asthma and COPD patients –a prospective cross-sectional study on inhaler preferences and error rates,’’ BMC Pulm. Med., 20, 1-12, 2020.
3. [3] C. Jenkins, “Drugs for chronic obstructive pulmonary disease,’’ Aust. Prescr., 40, 15-19, 2017.
4. [4] F. Martinelli, E. G. Balducci, A. Rossi, and F. Sonvico, ’’ Pierce and inhale design in capsule based dry powder inhalers: Effect of capsule piercing and motion on aerodynamic performance of drugs,’’ Int. J. Pharm., 487, 197-204, 2015.
5. [5] A. J. Hickey, Inhalation Aerosols: Physical and Biological Basis for Therapy. Marcel Dekker Inc., New York, 1996.
6. [6] N. Islam and M. J. Cleary, ’’Developing an efficient and reliable dry powder inhaler for pulmonary drug delivery–a review for multidisciplinary researchers,’’ Med. Eng. Phys., 34, 409–427, 2012.
7. [7] E. A. Matida, W. H. De Haan, W. H. Finlay, and C. F. Lange, ’’Simulation of particle deposition in an idealized mouth with different small diameter inlets,’’ Aerosol Sci. Tech., 37, 924–932, 2003.
8. [8] P. Rogliani, L. Calzetta, A. Coppola, F. Cavalli, J. Ora, E. Puxeddu, M. G. Matera, and M. Cazzola, “Optimizing drug delivery in COPD: The role of inhaler devices,’’ Resp. Med., 124, 6-14, 2017.

9. [9] F. Lavorini, A. Magnan, J. C. Dubus, T. Voshaar, L Corbetta, M. Broeders et al. ’’Effect of incorrect use of dry powder inhalers on management of patients with asthma and COPD,’’Resp. Med., 102, 593-604, 2008.
10. [10] F. Lavorini, C. Janson, F. Braido, C. Stratelis, and A. Løkke, ’’What to consider before prescribing inhaled medications: a pragmatic approach for evaluating the current inhaler landscape,’’ Ther. Adv. Respir. Di.s, 13, 1–28, 2019.
11. [11] M. Katsurada, T. Nagano, T. Nakajima, Y. Yasuda, N. Miwa, R. Sekiya, K. Kobayashi, D. Hojo, and Y. Nishimura,’’ Retrospective analysis of the effect of inhaler education on improvements in inhaler usage,’’ Respiratory Investigation, 59, 312-319, 2021.
12. [12] S. Khera, H. Landau, S. M. Hon, J. L. Breezed, N. Al-Naamani, J. K. Pauluse, A. Martin, and R. Tsacoyianis, “Inhaler use and education characteristics among English and non-English speaking patients: A pilot needs assessment survey,’’ Patient. Educ. Couns., 102, 932-936, 2019.
13. [13] F. Lavorini, M. Pistolesi, and O. S. Usmani, “Recent advances in capsule-based dry powder inhaler technology,’’ Multidiscip. Resp. Med., 12, 1-7, 2017.
14. [14] H. Chrystyn, ’’A review of its position among dry powder inhaler devices,’’ Int. J. Clin. Pract., 61, 1022–1036, 2007.
15. [15] M. J. Donovan, S. H. Kim, V. K. Raman, and H. D. C. Smyth, ’’Dry powder inhaler device influence on carrier particle performance,’’ J. Pharm Sci., 1013, 1097-1107, 2012.
16. [16] I. Ding, A. D. Brunaugh, S. Stegemann, S. V. Jermain, M. J. Herpin, J. Kalafat, and H. D. C. Smyth, “A Quality by design framework for capsule-based dry powder inhalers,’’ Pharmaceutics, 13, 1-26, 2021.
17. [17] M. Kuentz, B. Rothenhäusler, and D. Röthlisberger,’’Time domain 1H NMR as a new method to monitor softening of gelatin and HPMC capsule shells,’’ Drug. Dev. Ind. Pharm., 32, 1165–1173, 2006.
18. [18] S. Tan and J. Newton, “Influence of capsule dosator wall texture and powder properties on the angle of wall friction and powder-wall adhesion,” Int. J. Pharm., 64, 227–234, 1990.
19. [19] P. Selvam, D. McNair, R. Truman, and H. D. C. Smyth, “A novel dry powder inhaler: Effect of device design on dispersion performance,” Int. J. Pharm., 401, 1–6, 2010.