Hybrid Deep Learning and Reinforcement Learning Approach for Brain Tumor Classification from MRI Images
Abstract
Brain cancer, resulting from abnormal tumor growth in brain tissue, requires accurate and timely diagnosis. Although MRI plays a crucial role, manual interpretation is prone to errors and delays. To address this, we propose a hybrid system combining deep learning (VGG16, ResNet50, DenseNet201) with reinforcement learning (Q-learning) for brain tumor classification. Using three distinct MRI datasets within MATLAB, the models achieved high classification accuracies: 97.45% (VGG16), 96.06% (ResNet50), and 96.93% (DenseNet201). The integration of reinforcement learning improved decision-making and interpretability. Additionally, a user-friendly interface was developed to support clinical decision-making. This study demonstrates that combining deep learning with reinforcement learning enhances model adaptability, offering a more reliable and effective diagnostic approach.
Keywords
References
- S. Rasheed, K. Rehman and M. S. H. Akash, "An insight into the risk factors of brain tumors and their therapeutic interventions", Biomedicine & Pharmacotherapy, 143, 112119, 2021.
- Q. T. Ostrom, M. Price, C. Neff, G. Cioffi, K. A. Waite, C. Kruchko and J. S. Barnholtz-Sloan, "CBTRUS Statistical Report: Primary brain and other central nervous system tumors diagnosed in the United States in 2015-2019", Neuro-Oncology, 24(Suppl 5), v1-v95, 2022.
- A. M. Molinaro, J. W. Taylor, J. K. Wiencke and M. R. Wrensch, "Genetic and molecular epidemiology of adult diffuse glioma", Nature Reviews Neurology, 15(7), 405-417, 2019.
- A. Thakur, C. Faujdar, R. Sharma, S. Sharma, B. Malik, K. Nepali and J. P. Liou, "Glioblastoma: Current status, emerging targets, and recent advances", Journal of Medicinal Chemistry, 65(13), 8596-8685, 2022.
- T. Wang, Y. Ni and L. Liu, "Innovative imaging techniques for advancing cancer diagnosis and treatment", Cancers, 16(14), 2607, 2024.
- T. Yousaf, G. Dervenoulas and M. Politis, "Advances in MRI methodology", International Review of Neurobiology, 141, 31-76, 2018.
- Z. Zhou and Z. R. Lu, "Gadolinium-based contrast agents for magnetic resonance cancer imaging", Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 5(1), 1-18, 2013.
- Y. Yu, D. H. Lee, S. L. Peng, K. Zhang, Y. Zhang, S. Jiang, et al., "Assessment of glioma response to radiotherapy using multiple MRI biomarkers with manual and semiautomated segmentation algorithms", Journal of Neuroimaging, 26(6), 626-634, 2016.
Details
Primary Language
English
Subjects
Bioinformatics and Computational Biology (Other)
Journal Section
Research Article
Publication Date
November 26, 2025
Submission Date
May 7, 2025
Acceptance Date
November 14, 2025
Published in Issue
Year 2025 Volume: 20 Number: 2
APA
Saraç, Ç., Arıkan Arıbal, S., & Üncü, Y. A. (2025). Hybrid Deep Learning and Reinforcement Learning Approach for Brain Tumor Classification from MRI Images. Süleyman Demirel University Faculty of Arts and Science Journal of Science, 20(2), 206-221. https://doi.org/10.29233/sdufeffd.1694369
AMA
1.Saraç Ç, Arıkan Arıbal S, Üncü YA. Hybrid Deep Learning and Reinforcement Learning Approach for Brain Tumor Classification from MRI Images. Süleyman Demirel University Faculty of Arts and Science Journal of Science. 2025;20(2):206-221. doi:10.29233/sdufeffd.1694369
Chicago
Saraç, Çiğdem, Seda Arıkan Arıbal, and Yiğit Ali Üncü. 2025. “Hybrid Deep Learning and Reinforcement Learning Approach for Brain Tumor Classification from MRI Images”. Süleyman Demirel University Faculty of Arts and Science Journal of Science 20 (2): 206-21. https://doi.org/10.29233/sdufeffd.1694369.
EndNote
Saraç Ç, Arıkan Arıbal S, Üncü YA (November 1, 2025) Hybrid Deep Learning and Reinforcement Learning Approach for Brain Tumor Classification from MRI Images. Süleyman Demirel University Faculty of Arts and Science Journal of Science 20 2 206–221.
IEEE
[1]Ç. Saraç, S. Arıkan Arıbal, and Y. A. Üncü, “Hybrid Deep Learning and Reinforcement Learning Approach for Brain Tumor Classification from MRI Images”, Süleyman Demirel University Faculty of Arts and Science Journal of Science, vol. 20, no. 2, pp. 206–221, Nov. 2025, doi: 10.29233/sdufeffd.1694369.
ISNAD
Saraç, Çiğdem - Arıkan Arıbal, Seda - Üncü, Yiğit Ali. “Hybrid Deep Learning and Reinforcement Learning Approach for Brain Tumor Classification from MRI Images”. Süleyman Demirel University Faculty of Arts and Science Journal of Science 20/2 (November 1, 2025): 206-221. https://doi.org/10.29233/sdufeffd.1694369.
JAMA
1.Saraç Ç, Arıkan Arıbal S, Üncü YA. Hybrid Deep Learning and Reinforcement Learning Approach for Brain Tumor Classification from MRI Images. Süleyman Demirel University Faculty of Arts and Science Journal of Science. 2025;20:206–221.
MLA
Saraç, Çiğdem, et al. “Hybrid Deep Learning and Reinforcement Learning Approach for Brain Tumor Classification from MRI Images”. Süleyman Demirel University Faculty of Arts and Science Journal of Science, vol. 20, no. 2, Nov. 2025, pp. 206-21, doi:10.29233/sdufeffd.1694369.
Vancouver
1.Çiğdem Saraç, Seda Arıkan Arıbal, Yiğit Ali Üncü. Hybrid Deep Learning and Reinforcement Learning Approach for Brain Tumor Classification from MRI Images. Süleyman Demirel University Faculty of Arts and Science Journal of Science. 2025 Nov. 1;20(2):206-21. doi:10.29233/sdufeffd.1694369