Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels

Zehra Özbaş; Gülten Gürdağ

doi:10.19113/sdufbed.53790

Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels

Abstract

In this work, the characterization and drug release behavior of 5-fluorouracil-loaded glutaraldehyde-crosslinked chitosan hydrogels have been studied. The structure of the hydrogels were investigated by Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction, also their properties were compared with those of the drug-unloaded hydrogels. The equilibrium swelling studies and drug release profiles were determined at 37°C in two different pHs (2.1 and 7.4). The results indicated that increased chitosan concentration in the hydrogel decreased the swelling and drug release values and the hydrogels released nearly the same amount of 5-fluorouracil in both acidic (~59%) and basic medium (~50%).

Keywords

Chitosan,Crosslinking; Drug delivery; 5-Fluorouracil

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Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Zehra Özbaş

Gülten Gürdağ This is me

Publication Date

November 18, 2016

Submission Date

June 7, 2016

Acceptance Date

-

Published in Issue

Year 2016 Volume: 20 Number: 3

DOI

https://doi.org/10.19113/sdufbed.53790

IZ

https://izlik.org/JA57JA43NU

Cite

RIS / Bibtex

APA

Özbaş, Z., & Gürdağ, G. (2016). Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 20(3), 460-467. https://doi.org/10.19113/sdufbed.53790

AMA

1.Özbaş Z, Gürdağ G. Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels. J. Nat. Appl. Sci. 2016;20(3):460-467. doi:10.19113/sdufbed.53790

Chicago

Özbaş, Zehra, and Gülten Gürdağ. 2016. “Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels”. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 20 (3): 460-67. https://doi.org/10.19113/sdufbed.53790.

EndNote

Özbaş Z, Gürdağ G (December 1, 2016) Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 20 3 460–467.

IEEE

[1]Z. Özbaş and G. Gürdağ, “Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels”, J. Nat. Appl. Sci., vol. 20, no. 3, pp. 460–467, Dec. 2016, doi: 10.19113/sdufbed.53790.

ISNAD

Özbaş, Zehra - Gürdağ, Gülten. “Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels”. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 20/3 (December 1, 2016): 460-467. https://doi.org/10.19113/sdufbed.53790.

JAMA

1.Özbaş Z, Gürdağ G. Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels. J. Nat. Appl. Sci. 2016;20:460–467.

MLA

Özbaş, Zehra, and Gülten Gürdağ. “Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels”. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, vol. 20, no. 3, Dec. 2016, pp. 460-7, doi:10.19113/sdufbed.53790.

Vancouver

1.Zehra Özbaş, Gülten Gürdağ. Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels. J. Nat. Appl. Sci. 2016 Dec. 1;20(3):460-7. doi:10.19113/sdufbed.53790