Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels

Year 2016, Volume: 20 Issue: 3, 460 - 467, 18.11.2016

Zehra Özbaş , Gülten Gürdağ

https://doi.org/10.19113/sdufbed.53790

Cited By: 5

https://izlik.org/JA57JA43NU

Abstract

In this work, the characterization and drug release behavior of 5-fluorouracil-loaded glutaraldehyde-crosslinked chitosan hydrogels have been studied. The structure of the hydrogels were investigated by Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction, also their properties were compared with those of the drug-unloaded hydrogels. The equilibrium swelling studies and drug release profiles were determined at 37°C in two different pHs (2.1 and 7.4). The results indicated that increased chitosan concentration in the hydrogel decreased the swelling and drug release values and the hydrogels released nearly the same amount of 5-fluorouracil in both acidic (~59%) and basic medium (~50%).

Keywords

Chitosan , Crosslinking; Drug delivery; 5-Fluorouracil

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