Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels

Zehra Özbaş; Gülten Gürdağ

doi:10.19113/sdufbed.53790

Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels

Öz

In this work, the characterization and drug release behavior of 5-fluorouracil-loaded glutaraldehyde-crosslinked chitosan hydrogels have been studied. The structure of the hydrogels were investigated by Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction, also their properties were compared with those of the drug-unloaded hydrogels. The equilibrium swelling studies and drug release profiles were determined at 37°C in two different pHs (2.1 and 7.4). The results indicated that increased chitosan concentration in the hydrogel decreased the swelling and drug release values and the hydrogels released nearly the same amount of 5-fluorouracil in both acidic (~59%) and basic medium (~50%).

Anahtar Kelimeler

Chitosan,Crosslinking; Drug delivery; 5-Fluorouracil

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Zehra Özbaş

Gülten Gürdağ Bu kişi benim

Yayımlanma Tarihi

18 Kasım 2016

Gönderilme Tarihi

7 Haziran 2016

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2016 Cilt: 20 Sayı: 3

DOI

https://doi.org/10.19113/sdufbed.53790

IZ

https://izlik.org/JA57JA43NU

Kaynak Göster

RIS / Bibtex

APA

Özbaş, Z., & Gürdağ, G. (2016). Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 20(3), 460-467. https://doi.org/10.19113/sdufbed.53790

AMA

1.Özbaş Z, Gürdağ G. Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels. Süleyman Demirel Üniv. Fen Bilim. Enst. Derg. 2016;20(3):460-467. doi:10.19113/sdufbed.53790

Chicago

Özbaş, Zehra, ve Gülten Gürdağ. 2016. “Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels”. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 20 (3): 460-67. https://doi.org/10.19113/sdufbed.53790.

EndNote

Özbaş Z, Gürdağ G (01 Aralık 2016) Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 20 3 460–467.

IEEE

[1]Z. Özbaş ve G. Gürdağ, “Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels”, Süleyman Demirel Üniv. Fen Bilim. Enst. Derg., c. 20, sy 3, ss. 460–467, Ara. 2016, doi: 10.19113/sdufbed.53790.

ISNAD

Özbaş, Zehra - Gürdağ, Gülten. “Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels”. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 20/3 (01 Aralık 2016): 460-467. https://doi.org/10.19113/sdufbed.53790.

JAMA

1.Özbaş Z, Gürdağ G. Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels. Süleyman Demirel Üniv. Fen Bilim. Enst. Derg. 2016;20:460–467.

MLA

Özbaş, Zehra, ve Gülten Gürdağ. “Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels”. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, c. 20, sy 3, Aralık 2016, ss. 460-7, doi:10.19113/sdufbed.53790.

Vancouver

1.Zehra Özbaş, Gülten Gürdağ. Synthesis and Characterization of 5-Fluorouracil-Loaded Glutaraldehyde Crosslinked Chitosan Hydrogels. Süleyman Demirel Üniv. Fen Bilim. Enst. Derg. 01 Aralık 2016;20(3):460-7. doi:10.19113/sdufbed.53790