Molecular Mechanic Studies on the Zwitterionic and Neutral Conformation Stability of Biological Active Peptide
Abstract
In this current work the conformational properties of the L-Alanyl-L-Glutamine dipeptide which was biological active dipeptide has been investigated by theoretical conformational analysis method using program which is based on Molecular Mechanic calculations in order to determine the structure function relation. The calculations on zwitterionic and neutral form of Ala-Gln which is formed side and main chain torsion angles let us to define their preferable energetically conformers. The side and main chain status of the stable conformations of Ala-Gln were acquired based on the results of the conformational analysis. By using Ramachandran maps, the global conformation, which has the lowest energy of the dipeptide, has been determined. The goal of this work was to explain structure-activity relationship by investigating the bioactive conformation of biological active peptide.
Keywords
References
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Details
Primary Language
Turkish
Subjects
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Journal Section
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Publication Date
October 24, 2017
Submission Date
April 13, 2017
Acceptance Date
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Published in Issue
Year 2017 Volume: 21 Number: 3
APA
Kecel Gunduz, S., & Celık, S. (2017). Molecular Mechanic Studies on the Zwitterionic and Neutral Conformation Stability of Biological Active Peptide. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 21(3), 836-842. https://doi.org/10.19113/sdufbed.02983
AMA
1.Kecel Gunduz S, Celık S. Molecular Mechanic Studies on the Zwitterionic and Neutral Conformation Stability of Biological Active Peptide. J. Nat. Appl. Sci. 2017;21(3):836-842. doi:10.19113/sdufbed.02983
Chicago
Kecel Gunduz, Serda, and Sefa Celık. 2017. “Molecular Mechanic Studies on the Zwitterionic and Neutral Conformation Stability of Biological Active Peptide”. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 21 (3): 836-42. https://doi.org/10.19113/sdufbed.02983.
EndNote
Kecel Gunduz S, Celık S (December 1, 2017) Molecular Mechanic Studies on the Zwitterionic and Neutral Conformation Stability of Biological Active Peptide. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 21 3 836–842.
IEEE
[1]S. Kecel Gunduz and S. Celık, “Molecular Mechanic Studies on the Zwitterionic and Neutral Conformation Stability of Biological Active Peptide”, J. Nat. Appl. Sci., vol. 21, no. 3, pp. 836–842, Dec. 2017, doi: 10.19113/sdufbed.02983.
ISNAD
Kecel Gunduz, Serda - Celık, Sefa. “Molecular Mechanic Studies on the Zwitterionic and Neutral Conformation Stability of Biological Active Peptide”. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 21/3 (December 1, 2017): 836-842. https://doi.org/10.19113/sdufbed.02983.
JAMA
1.Kecel Gunduz S, Celık S. Molecular Mechanic Studies on the Zwitterionic and Neutral Conformation Stability of Biological Active Peptide. J. Nat. Appl. Sci. 2017;21:836–842.
MLA
Kecel Gunduz, Serda, and Sefa Celık. “Molecular Mechanic Studies on the Zwitterionic and Neutral Conformation Stability of Biological Active Peptide”. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, vol. 21, no. 3, Dec. 2017, pp. 836-42, doi:10.19113/sdufbed.02983.
Vancouver
1.Serda Kecel Gunduz, Sefa Celık. Molecular Mechanic Studies on the Zwitterionic and Neutral Conformation Stability of Biological Active Peptide. J. Nat. Appl. Sci. 2017 Dec. 1;21(3):836-42. doi:10.19113/sdufbed.02983